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Sulfareptol 960 drug has the main active ingredients are Sulfamethoxazole, Trimethoprim and other excipients in sufficient quantities. This is an antibiotic with anti-parasitic, anti-bacterial, anti-viral, and anti-fungal properties.
1. What is Sulfareptol 960?
Sulfareptol 960 drug has the main active ingredients are Sulfamethoxazole, Trimethoprim and other excipients in sufficient quantities. This is an antibiotic with anti-parasitic, anti-bacterial, anti-viral, and anti-fungal properties.
Sulfareptol 960 has a dosage form of tablets, suitable for direct oral use. Packing is a box of 10 blisters, each blister contains 10 tablets.
Sulfamethoxazole is a sulphonamide in combination with the active ingredient Trimethoprim which is a pyrimidine derivative synthetic antibiotic. These two types of active ingredients are often combined with each other in the ratio of 1 Trimethoprim and 5 Sulfamethoxazole. This combination creates an enhanced synergistic effect that increases the effectiveness of treatment and reduces drug resistance.
After oral administration, both active ingredients, Trimethoprim and Sulfamethoxazole, are rapidly absorbed and have high bioavailability. The mean half-life of active ingredient Trimethoprim is 9 to 10 hours, of active substance Sulfamethoxazole 11 hours. Therefore, taking the medicine should be 12 hours apart. Trimethoprim is able to penetrate into tissues and secretions better than Sulfamethoxozol. The drug concentration in the urine was 150 times higher than the concentration in the serum.
2. What diseases does Sulfareptol 960 use to treat?
Sulfareptol 960 is a broad-spectrum treatment for Gram (-), Gram (+) bacterial infections, especially gonococcal infections, uncomplicated acute urinary tract infections and people pneumonia caused by Pneumocystis carinii.
Treatment of infections caused by microorganisms sensitive to Sulfamethoxazole and Trimethoprim Treatment of urinary tract infections . Treatment of infectious prostatitis. Treatment of respiratory tract infections. Treatment of acute exacerbations in chronic bronchitis. Treatment of acute purulent sinusitis in adults. Treatment of gastrointestinal infections: Bacillary dysentery.
3. Usage and dosage of Sulfareptol 960
3.1. How to use the drug Sulfareptol 960 is prepared in the form of tablets, suitable for oral use.
3.2. Subjects using the drug You can only use it when prescribed by a medical doctor.
3.3. Dosage of the drug Treatment of urinary tract infections:
For adults: the dose is 800 mg Trimethoprim + 160 mg Sulfamethoxazol, 12 hours apart, for 10 days. Or single-dose therapy: 320 mg Trimethoprim + 1600 mg Sulfamethoxazol (but at least for 3 or 7 days). For children: the dose is 8 mg Trimethoprim/kg + 40 mg Sulfamethoxazole/kg, divided into 2 doses 12 hours apart, for a duration of 10 days. Treatment of chronic urinary tract infections: the dose is 40 mg of trimethoprim + 200 mg of Sulfamethoxazol/day, or an amount 2 to 4 times that dose, orally once or twice a week. (effectively reduce the number of disease relapses). Treatment of respiratory infections
Treatment of acute exacerbations of chronic bronchitis: Adults: use 10 - 240 mg of Trimethoprim + 800 - 1200 mg of Sulfamethoxazol, 2 times a day, for a period of 10 days. Treatment of acute otitis media, acute pneumonia in children: a dose of 8 mg of Trimethoprim/kg and 40 mg of Sulfamethoxazol/kg, divided into 2 doses 12 hours apart, for a period of 5 to 10 days . Treatment of pneumonia in children and adults: 20 mg of Trimethoprim/kg + 100 mg of Sulfamethoxazol/kg in 24 hours, equally divided 6 hours apart, for a period of 14 to 21 days of treatment. 3.4. Treatment of drug overdose In the case of drug overdose, you may experience nausea, vomiting, headache,...
Treatment: induce vomiting, gastric lavage. Acidification of urine to increase excretion of active substance Trimethoprim. If there are signs of myelosuppression, the doctor will prescribe Leucovorin (folinic acid) 5-15 mg/day until hematopoietic recovery.
4. Undesirable effects of the drug Sulfareptol 960
Occurs in 10% of patients. The most common adverse effects occurred in the gastrointestinal tract and skin reactions such as rash, blisters. Adverse effects are usually mild, but sometimes very severe, potentially fatal toxic skin syndromes such as Lyell's syndrome occur.
Common side effects of Sulfareptol 960, are as follows:
Whole body: fever. For the digestive system: nausea, vomiting, loss of appetite, diarrhea, glossitis. For the skin: itching, rash, or glossitis. Uncommon side effects of Sulfareptol 960 are as follows:
For blood: Increased number of eosinophils, decreased white blood cell count, decreased neutrophil count, purpura. For skin: Appears urticaria on the skin. For the whole body: headache, blurred vision, dizziness, diarrhea, loss of appetite For the kidneys: interstitial nephritis, tubular necrosis, which can lead to kidney failure. You need to proactively notify the treating doctor when you encounter unwanted effects during the use of the drug.
5. Interaction of Sulfareptol 960
Drug Sulfareptol 960 may cause interactions when used with thiazide diuretics, warfarin, phenytoin, methotrexate, pyrimethamine, hypoglycemic drugs, cyclosporin, indomethacin.
When using the drug Sulfareptol 960 with foods or alcohol, beer, tobacco... because those foods and drinks contain other active ingredients, they can affect and cause antagonism or antagonism. drug synergism. You need to actively read the drug instructions carefully or consult your doctor about the use of Sulfareptol 960 with foods, alcohol and tobacco.
6. Some notes when using Sulfareptol 960
6.1. Contraindications of the drug Sulfareptol 960 Patients with severe renal failure without monitoring the drug concentration in the blood plasma. The patient was diagnosed with megaloblastic anemia caused by folic acid deficiency. People who are sensitive or sensitive to Sulfonamide or Trimethoprim components. 6.2. Caution when using the drug Sulfareptol 960 You need to be careful in the process of taking the drug for the following cases:
Decreased liver and kidney function People at risk of folic acid deficiency for the elderly and when using the drug high doses for long periods of time. Dehydrated people. Malnourished people. Sulfonamides can cause hemolytic anemia in people with G6PD deficiency. For pregnant women: Sulfareptol 960 used during pregnancy can cause adverse effects, namely miscarriage, teratogenicity, and fetal malformations. .. to any developmental stage of pregnancy, especially during the first trimester. Therefore, it is best not to use the drug for pregnant women. In cases where treatment is required, it is necessary to carefully consult the doctor treating the disease before deciding to use this drug. For women who are breast-feeding: Sulfareptol 960 can be passed on to the baby through breastfeeding and the newborn is very sensitive to the unwanted effects of the drug. Therefore, it is best not to or limit the use of Sulfareptol 960 during breast-feeding. Currently, there are many drugs that have not yet fully determined the effects of drugs during this period, mothers need to carefully read the instructions for use and consult the treating doctor or pharmacist before deciding to use the drug. For those who drive or regularly operate machinery: The drug has an undesirable effect of causing convulsions, dizziness, dizziness, drowsiness, fatigue, headache, insomnia, confusion. Psychiatric, tinnitus, dizziness may occur. Therefore, you need to be careful when using Sulfareptol 960 for people who often drive, operate machinery or do jobs that require high concentration. Above is all information about Sulfareptol 960, patients need to carefully read the instructions for use, consult the treating doctor/pharmacist before use. Absolutely do not arbitrarily buy Sulfareptol 960 to treat diseases at home, because there may be unwanted side effects on health.
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