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Ovacef 200 medicine has the main ingredient is Cefixim, this is an antibiotic used to treat infections caused by susceptible strains of bacteria such as otitis media, acute bronchitis, pharyngitis. mild to moderate pneumonia.1. What is Ovacef 200?
The main ingredient of Ovacef 200 is Cefixime 200mg, which is made in the form of hard capsules.Cefixim is an antibiotic of the 3rd generation cephalosporin group, used orally. The bactericidal mechanism of cefixime is similar to that of other cephalosporin antibiotics by binding to target proteins causing inhibition of mucopeptide synthesis in the bacterial cell wall.
Cefixime has high stability to the hydrolysis of beta-lactamase enzymes, because the stability to beta-lactamase of cefixime is higher than that of antibiotics cefaclor, cefuroxime, cefoxitin, cephalexin, cephradin, so the antibacterial spectrum is wider and difficult degraded by this yeast.
Cefixim is used in the treatment of infections caused by strains of bacteria susceptible to cefixime such as Streptococcus sp., Streptococcus pneumoniae, Neisseria gonorrhoeae, Branhamella catarrhalis, Escherichia coli, Serratia sp., Proteus sp., Haemophilus influenzae and Klebsiella sp.,
The mechanism of bacterial resistance to cefixime is to decrease the affinity of cefixime for the target protein or decrease the permeability of the bacterial cell membrane to this drug. Since then, many bacteria have developed resistance, so it is necessary to monitor the patient's response and it is best to make an antibiotic chart before using the drug.
2. Uses of Ovacef 200
Indications: Ovacef 200 is used to treat infections caused by susceptible strains of bacteria:Uncomplicated urinary tract infections such as urethritis, cystitis caused by susceptible strains . Middle ear infections, acute bronchitis and acute exacerbations of chronic bronchitis caused by bacteria such as Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes. Pharyngitis, rhinosinusitis and tonsillitis caused by Streptococcus pyogenes. Mild and moderate pneumonia, including community-acquired pneumonia. Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, used for beta-lactamase-producing strains. Note that Ovacef 200 should not be used when:
The patient has a history and is in shock due to treatment with the drug. Hypersensitivity to any cephalosporins or penicillins or to other ingredients of Ovacef 200.
3. Dosage and usage of Ovacef 200
How to use:The drug is taken orally, take it with water and should be taken at equal intervals, to increase the effectiveness of the drug.
Dosage:
Adults and children over 12 years old or children weighing > 50kg: Take 2 tablets of Ovacef 200 (equivalent to 400mg)/day can be used once or divided into 2 divided doses. 12 o'clock. Treatment of gonococcal infections is a single dose of 400mg Cefixime. Children > 6 months to less than 12 years of age, it is recommended that cefixime be used as an oral suspension at a dose of 8 mg/kg/day, which can be administered once a day or in 2 divided doses, 12 hours apart. . The safety and effectiveness of Cefixim in children under 6 months of age have not been verified, so it should not be used. Duration of treatment:
Depending on the type of infection, it should be extended from 48 to 72 hours after the symptoms of the infection have disappeared. Usual duration of treatment for uncomplicated UTIs and upper respiratory tract infections: At least 10 days of drug therapy to prevent rheumatic fever and 5 to 10 days if not due to group beta-hemolytic streptococci. A caused. For lower respiratory tract infections and otitis media: Use for 10-14 days. For patients with renal impairment:
For patients with creatinine clearance above 60ml/min, no dose adjustment is required. Clearances of 21-60ml/min or patients on hemodialysis can be dosed up to 75% of the standard dose. Clearance < 20 ml/min, or patients on peritoneal dialysis, the dose is half the standard dose.
4. How to handle missed dose and overdose Ovacef 200
Overdose An overdose of cefixime can cause convulsions. Since there is no specific treatment for overdose, symptomatic treatment is essential. When there are symptoms of overdose, the drug must be stopped immediately and treated with gastric lavage, anticonvulsants can be used if clinically indicated. Because the drug cannot be removed by hemodialysis, hemodialysis and peritoneal dialysis are not recommended.Missed dose Take another dose as soon as you remember it. However, if the interval between the next dose is too short, skip the missed dose directly and continue with your dosing schedule.
5. Ovacef 200 . side effects
When using Ovacef 200 may have undesirable effects such as:Common: Diarrhea, broken stools, abdominal pain, vomiting, nausea, bloating, loss of appetite, dry mouth; Headache, dizziness, restlessness, insomnia, fatigue, seizures; Erythema, urticaria, drug fever. Uncommon: Severe diarrhea caused by Clostridium difficile and pseudomembranous colitis; anaphylaxis, angioedema, Stevens-Johnson syndrome, allergic erythema multiforme, toxic epidermal necrolysis; Thrombocytopenia, leukopenia and transient eosinophilia, decreased hemoglobin and hematocrit levels; Hepatitis and jaundice, temporary increase in GOT, GPT, alkaline phosphatase, bilirubin and increase in LDH; Acute renal failure, transient increase in plasma creatinine concentration; Fungal growth causes vaginal candidiasis. Rare: Prothrombin time prolonged; cause convulsions. When experiencing side effects of Ovacef 200, you should stop using it and notify your doctor or go to the nearest medical facility for timely treatment.
6. Notes when using Ovacef 200
Before using the drug, you need to inform your doctor about your history of allergies and accompanying medical conditions when taking the drug.Antibiotics are only used to treat bacterial infections, you do not arbitrarily use to treat viral infections or there is no evidence of infection.
Do not take this medicine with any other medicine containing cefixime.
Use caution when using this drug in patients with renal failure, history of penicillin allergy, gastrointestinal disease, especially pseudomembranous colitis.
When taking the drug can cause the growth of non-susceptible bacteria, fungi to the extent of causing disease. Therefore, do not use it for a long time and if there are abnormal symptoms such as severe diarrhea, it is necessary to think of a gastrointestinal infection and take appropriate treatment.
Cephalosporin antibiotics can cause hemolytic anemia, therefore use with caution in patients with a history of cephalosporin-induced hemolytic anemia.
Ability to drive and use machines: Ovacef 200 should be used with caution while operating machinery and driving a vehicle because it may cause symptoms such as headache, dizziness and affect the ability to operate.
Pregnancy: This drug can cross the placenta, but to date there are no adequate data on the use of cefixime in pregnant women, during labor and delivery. Therefore, drugs are only used for these cases when absolutely necessary.
Lactation: At present, it has not been established with certainty that cefixime can be distributed into breast milk in lactating women. Therefore, the drug should be used with caution in lactating women and it may be advisable to discontinue breastfeeding while taking the drug.
Drug interactions:
Probenecid may increase peak cefixime concentrations, decrease renal clearance and volume of distribution. Anticoagulants such as warfarin, when taken with cefixime, increase prothrombin time, with or without associated bleeding. Carbamazepine if taken with cefixime will increase the concentration of carbamazepine in the blood plasma. Nifedipine, when co-administered with cefixime, increases the bioavailability of cefixime resulting in an increase in peak plasma concentrations. Storage: Store in a dry place, the drug storage temperature should not exceed 30 degrees Celsius, avoid direct light. Keep medicine out of reach of children. Do not use when expired and show signs of damage.
Hopefully, with the above drug information, you already know what Ovacef 200 is and how it works and how to use it. To limit the risk of drug resistance, you should not self-administer and strictly follow the instructions of the drug.
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