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Skypodox medicine 200mg with the main active ingredient is Cefpodoxime used in the treatment of respiratory tract infections or urinary tract infections.
1. What is skypodox 200mg?
Skypodox medicine 200mg with the main active ingredient is Cefpodoxime, which is prepared in the form of dispersible tablets with the effect of treating respiratory infections or urinary tract infections.
2. Pharmacokinetics and pharmacodynamics of skypodox 200
Cefpodoxime is an antibiotic belonging to the 3rd generation Cephalosporin group. This group is highly resistant to attack by beta-lactamases caused by gram-negative and gram-positive bacteria.
After entering the body, Cefpodoxime proxetil is rapidly absorbed and metabolized to Cefpodoxime and can enter the bloodstream. At a dose of 100 mg, mean plasma concentrations peak within 2 hours. When the drug is taken with meals, absorption and mean peak plasma concentrations are increased. Skypodox 200 is approximately 40% bound to plasma proteins. The mechanism of action of Cefpodoxime is by its ability to inhibit bacterial cell wall synthesis by acylation of membrane-bound transpeptidase enzymes. This prevents cross-linking of the peptidoglycan chains required for the strength and strength of the bacterial cell wall.
3. Indications of the drug skypodox
Cefpodoxime proxetil inhibits the destruction of gram-positive and gram-negative bacteria and is stable to beta-lactamases. Its antibacterial spectrum includes Staphylococcus aureus with the exception of methicillin-resistant Staphylococci, Streptococcus pneumoniae, Streptoccocus pyogenes, Streptococcus agalactiae and Streptococcus spp. other. Gram-negative bacteria susceptible to cefpodoxime include beta-lactamase-producing and non-beta-lactamase-producing strains of some bacteria, such as H. influenzae, H. para-influenzae, Neisseria meningitidis, Moraxella catarrhalis, Neisseria gonorrhoea , Klebsiella pneumoniae, E. coli, Providencia rettgeri, Proteus vulgaris and Citrobacter diversus . In addition, Cefpodoxime is also effective against Peptostreptococcus spp.
Therefore, the drug is indicated in the following infections:
Upper respiratory tract infections including sinusitis, acute otitis media, pharyngitis and tonsillitis. Acute community-acquired pneumonia. Uncomplicated acute gonococcal infection. Uncomplicated urinary tract infections. Skin and skin structure infections.
4. How to use skypodox 200mg
In adults:
Treatment of upper respiratory tract infections including pharyngitis and tonsillitis: Use 100 mg within 12 hours, for 10 days. Community-acquired acute pneumonia: 200 mg within 12 hours for 14 days. Uncomplicated acute gonococcal infection: Use a single dose of 200 mg. Uncomplicated urinary tract infections: 100 mg within 12 hours, for 7 days. Skin and skin structure infections: 400 mg within 12 hours, lasting 7-14 days. In children:
Acute otitis media: Use 10 mg/kg/day. The maximum dose is 400 mg / day divided into 2 times, orally for 10 days. Tonsillitis and pharyngitis: Use 10 mg/kg/day. The maximum dose is 200mg / day divided into 2 times, orally lasting for 10 days. For patients with renal impairment with creatinine clearance less than 30 ml/min, the dosing interval should be increased to 24 hours. The drug is contraindicated in patients with a history of sensitivity to cefpodoxime proxetil.
5. Interaction between skypodox 200 with other drugs
When Cefpodoxime proxetil is co-administered with antacids or H2-antihistamines, plasma concentrations are reduced by approximately 30%. When administering Cefpodoxime concurrently with potentially nephrotoxic active ingredients, renal function should be closely monitored. Performing a Coomb test on patients receiving Cephalosporins gives a positive value.
6. Some side effects of skypodox 200mg
Side effects recorded through clinical trials are usually mild and transient, including: Diarrhea, nausea, vomiting, colitis and headache, abdominal pain. More serious reactions such as hypersensitivity, pruritus, rash, dizziness, thrombocytopenia or thrombocytopenia, eosinophilia or leukopenia are rare.
Skypodox medicine 200mg with the main active ingredient is Cefpodoxime used in the treatment of respiratory tract infections or urinary tract infections. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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