Uses of Cefpomax

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1. Uses of the drug Cefpomax

1 Cefpomax 200 tablet contains 200mg of Cefpodoxime (as Cefpodoxime proxetil) and other excipients. Cefpodoxime belongs to the group of 3rd generation cephalosporin antibiotics. The antibacterial action of Cefpodoxime is through inhibition of bacterial cell wall synthesis by acylation of membrane-bound transpeptidase enzymes. This prevents the cross-linking of peptidoglycan chains essential for bacterial cell wall strength and durability.
Cefpodoxime proxetil has a broad spectrum of antibacterial activity against gram-negative and gram-positive bacteria. The drug is stable to beta-lactamase.
Indications for use of Cefpomax: Treatment of patients with mild to moderate infections caused by susceptible strains of bacteria causing the following diseases:
Lower respiratory tract: Community acquired pneumonia , caused by S. pneumoniae or H. influenzae (including beta - lactamase producing strains); Acute exacerbation of chronic bronchitis caused by S.pneumoniae , H.influenzae (only strains that do not produce beta - lactamase) or M. catarrhalis; Upper respiratory tract: Acute maxillary sinusitis caused by H.influenzae (including beta - lactamase producing strains), Streptococcus pneumoniae and Moraxella catarrhalis; Acute otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase-producing strains) or Moraxella (Branhamella) catarrhalis; Pharyngitis, tonsillitis caused by Streptococcus pyogenes; Sexually Transmitted Diseases: Acute, uncomplicated cervical and urethral gonorrhea caused by Neisseria gonorrhoeae (including penicillinase-producing strains); Acute, uncomplicated Neisseria gonorrhoeae (including penicillinase-producing strains) infections of the anus and rectum in women; Skin and skin structures: Uncomplicated skin and skin structure infections caused by Staphylococcus aureus (including penicillinase-producing strains) or Streptococcus pyogenes; Urinary tract: Uncomplicated urinary tract infection (cystitis) caused by Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis or Staphylococcus saprophyticus. Contraindications to using Cefpomax:
Patients who are allergic to Cefpodoxime or other cephalosporin antibiotics. *Note:
Only penicillin administered intramuscularly is effective in the prevention of rheumatic fever. Cefpodoxime Proxetil is effective in the eradication of oropharyngeal Streptococcus. There are no data verifying the effectiveness of Cefpodoxime Proxetil in preventing the risk of subsequent rheumatic fever; The efficacy of Cefpodoxime has not been established in the treatment of male patients with rectal N.gonorrhoeae infection. There are currently no data on the use of Cefpodoxime Proxetil in the treatment of pharyngeal infections caused by N.gonorrhoeae; In clinical trials, efficacy in the treatment of uncomplicated skin and skin structure infections was dose dependent. The effective treatment dose for skin infections is higher than that used for other indications; Appropriate bacteriological tests should be performed to isolate and identify pathogenic bacteria and determine their susceptibility to cefpodoxime. Treatment can be done while waiting for the results of these tests. When results are available, antibiotic therapy should be adjusted accordingly.

2. How to use and dose of Cefpomax

Usage: Orally. Patients should take the drug with food to enhance its absorption.
Dosage:
For people 12 years and older:
Acute community-acquired pneumonia: 400mg/200mg every 12 hours for 14 days; Acute exacerbation of chronic bronchitis: 400mg/200mg every 12 hours, treat for 10 days; Acute maxillary sinusitis: 400mg/200mg every 12 hours for 10 days; Pharyngitis, tonsillitis: Dose 200mg/100mg every 12 hours, treat for 5-10 days; Uncomplicated gonorrhea (in men and women), gonococcal infection in the rectum (women): Take a single dose of 200mg; Uncomplicated skin and skin structure infections: 800mg/400mg every 12 hours, treat for 7-14 days; Uncomplicated urinary tract infections: 200mg/100mg every 12 hours, treat for 7 days; For patients with liver and kidney dysfunction:
Patients with renal dysfunction: In patients with severe renal impairment (creatinine clearance less than 30ml/min), the interval between doses should be increased to 24 hours. For patients on hemodialysis, the interval between doses is 3 times/week, taking the drug after dialysis; Cirrhotic patients: The pharmacokinetics of Cefpodoxime Proxetil in patients with cirrhosis (with or without ascites) were similar to those in healthy subjects. Therefore, no dose adjustment is required for this group of patients. For children from 2 months - under 12 years old:
Acute otitis media: Use dose 10mg/kg/day (maximum 400mg/day), 5mg/kg every 12 hours (maximum 200mg/dose), treat for 5 day; Pharyngitis, tonsillitis: Use dose 10mg/kg/day (maximum 200mg/day), 5mg/kg every 12 hours (maximum 100mg/dose), treatment for 5-10 days; Acute maxillary sinusitis: Use 10mg/kg/day (maximum 400mg/day), 5mg/kg every 12 hours (maximum 200mg/dose), treatment for 10 days. Overdose: There are currently no reports of an overdose of Cefpodoxime proxetil. Symptoms of an overdose may include: Nausea, vomiting, epigastric pain, and diarrhea. In the event of a severe toxic reaction from an overdose, hemodialysis or peritoneal dialysis may help remove cefpodoxime from the body, especially when renal function is impaired.

3. Side effects of the drug Cefpomax

Most of the side effects of Cefpomax are gastrointestinal effects of a mild, transient nature. Side effects that patients may experience when using Cefpomax include: Abdominal pain, nausea, diarrhea, loose stools, frequent bowel movements, indigestion and flatulence. Patients should immediately inform their doctor about the side effects they experience when using the drug for advice on the most appropriate treatment.

4. Be careful when using Cefpomax

Some precautions patients need to remember before and while taking Cefpomax:
Before starting treatment with Cefpodoxime proxetil, it is necessary to determine if the patient has had a previous hypersensitivity reaction to Cefpodoxime, other cephalosporins, penicillin or with other drugs not; For patients with temporary or prolonged urinary retention due to renal failure, the total daily dose of cefpodoxime proxetil should be reduced; Prolonged use of Cefpodoxime proxetil may result in overgrowth of non-susceptible organisms. Therefore, it is necessary to continuously re-evaluate the patient's health status; Cefpodoxime proxetil is used only in the treatment of bacterial infections. Do not use this medicine in the treatment of viral infections (such as the common cold). When prescribing treatment for infections, it is important to inform the patient that even if symptoms have improved, the dosing schedule should still be continued as originally indicated; There are currently no adequate studies on the use of cefpodoxime proxetil in pregnant women. Therefore, Cefpomax should be used during pregnancy only when absolutely necessary; Because of the potential for dangerous reactions in the nursing infant, a decision should be made whether to discontinue nursing or to discontinue cefpodoxime proxetil in nursing women.

5. Cefpomax drug interactions

Some drug interactions of Cefpomax include:
There are drug interactions between Cefpomax and antacids (sodium bicarbonate and aluminum hydroxide); Renal excretion of cefpodoxime is inhibited by probenecid ; There is a drug interaction between cefpodoxime proxetil and nephrotoxic drugs. During the use of Cefpomax, the patient should strictly follow all instructions and instructions of the doctor. Patients are not allowed to arbitrarily change the way, dose, time of taking the drug, ... without the permission of the doctor to avoid having adverse reactions to health.
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