This is an automatically translated article.
Rosu 5 Tablet is used in the treatment of hypercholesterolemia with the main ingredient Rosuvastatin 5mg. Let's find out more details about the uses, usage and notes when using Rosu 5 Tablet through the following article.
1. What is Rosu 5 Tablet?
Rosu 5 Tablet belongs to the group of cardiovascular drugs, used in the treatment and prevention of cardiovascular events & hypercholesterolemia.
Rosu 5 Tablet is prepared in the form of film-coated tablets packed in boxes of 3 blisters x 10 tablets. The drug has the main ingredient Rosuvastatin (in the form of Rosuvastatin calcium 5,210mg) content of 5mg and includes other excipients such as: Lactose, Lactose anhydrous, Calcium hydrogen phosphate (anhydrous), Micicrystallin cellulose (PH 102), Crospovidone, Kollidon CL, Magnesium stearate, Opadry II white 85G68918, D&C Yellow No.10, Carnauba Wax, Purified water.
Products of Popular Pharmaceuticals Ltd. - BANGLADESH.
2. Indications for taking Rosu 5 Tablet
Rosu 5 Tablet is used in the specific cases of adults and children over 6 years old as follows:
Treatment of primary hypercholesterolemia or mixed dyslipidemia, taking the drug as a regimen support measure. eat when there is an inadequate response to diet and non-pharmacological treatments such as weight loss and exercise. In the treatment of homozygous familial hypercholesterolemia, the drug is used as an adjunct to diet and other lipid-lowering therapies, or alone if the above therapies are not appropriate. To help prevent cardiovascular events in patients suspected of having a first cardiovascular event, the drug is used to aid in the adjustment of other risks.
3. Dosage - How to take Rosu 5 Tablet
Before using Rosu 5 Tablet for treatment, patients need to adhere to a standard cholesterol-lowering diet and need to maintain this regimen throughout the duration of drug treatment. Dosage is adjusted according to the patient's response and disease progression.
Initially 5 or 10 mg Rosuvastatin, once daily, if necessary, the dose can be adjusted every 4 weeks, the dose of 40 mg Rosuvastatin should only be used in severe hypercholesterolemia at high risk for cardiovascular disease without achieving control goals. At a dose of 20 mg Rosuvastatin, patients should be monitored regularly.
In patients with a history of liver disease, as with all statins, caution should be exercised in patients with predisposing factors for rhabdomyolysis such as renal failure, hypothyroidism, history of muscle toxicity due to HMG-CoA reductase inhibitors. other, personal or family history of hereditary muscle diseases or fibrates, alcoholism, patients over 70 years of age, conditions causing increased drug levels in the blood, concomitant use of fibrates.
Discontinue Rosuvastatin if CK > 5 x ULN or severe muscle symptoms. Rosuvastatin should not be used in the presence of sepsis, hypotension, trauma, major surgery, endocrinology, electrolyte disturbances, severe metabolism: uncontrolled convulsions.
4. Contraindications to taking Rosu 5 Tablet
Rosu 5 Tablet should not be used in the following cases:
Patients with hypersensitivity or history of allergy to Rosuvastatin or to any other excipients in the drug. Patients with active liver disease include unexplained persistent elevations in serum transaminases and elevations exceeding 3 times the upper limit of normal. Patients with severe kidney failure Patients with muscle pain Patients taking ciclosporin In case of pregnancy and breastfeeding or women who are suspected of being pregnant. The dose of 40 mg should not be used in patients at risk of myalgia and rhabdomyolysis such as: people with moderate renal impairment, hypothyroidism, patients or family with a history of hereditary muscle disorders, a history of myopathy when used with other HMG CoA inhibitors or Fibrates, alcoholics,...
5. Side effects when using Rosu 5 Tablet
Rosu 5 Tablet is usually quite well absorbed, the unwanted side effects that occur are usually mild and transient. In clinical trials, less than 4% of patients discontinued treatment due to adverse events.
Common:
Endocrine disorders: Diabetes, hyperglycemia, increased HbA1c Nervous disorders: Dizziness, headache, headache Digestive system disorders: Constipation, nausea, vomiting, abdominal pain Musculoskeletal and Connective Tissue Disorders: Myalgia Whole Body: Asthenia. Uncommon:
Skin and subcutaneous tissue disorders: pruritus, urticaria, rash Rare:
Blood disorders: Thrombocytopenia Immune system disorders: Angioedema + hypersensitivity reactions. Gastrointestinal disorders: Pancreatitis Hepatobiliary: Increased liver transaminases Musculoskeletal and connective tissue disorders: Myopathy includes myositis and rhabdomyolysis. Very rare:
Nervous system disorders: Polyneuropathy, cognitive impairment, confusion, memory loss,... Hepatobiliary disorders: Jaundice, hepatitis Musculoskeletal disorders: Arthralgia Renal and urinary tract disorders: Blood in urine Reproductive system and mammary gland disorders: Gynecomastia Not known:
Psychiatric disorders: Depression Nervous system disorders: Peripheral neuropathy , sleep disorders, insomnia, nightmares,.. Respiratory disorders: cough+difficulty breathing,.. Digestive system disorders: Diarrhea Skin disorders: Steven-Johnson syndrome. Musculoskeletal and connective tissue disorders: Ligament disorders, immune-mediated muscle necrosis. Body as a whole: Edema.
6. Rosu 5 Tablet drug interactions
Rosu 5 Tablet when combined with other drugs may occur drug interactions such as:
Inhibitors of Transporter Protein: Rosuvastatin is a substrate of Transporter Proteins such as Transport Protein outside the liver. BCRP and hepatic transporter protein OATP1B1. Concomitant administration of Rosuvastatin with Protein Transporter Inhibitors may increase plasma concentrations of Rosuvastatin and increase the risk of myopathy. Co-administration of Rosuvastatin with ciclosporin is not recommended because this combination does not alter plasma concentrations of ciclosporin. Concomitant use of lipid-lowering statins with drugs for HIV and hepatitis C may increase the risk of muscle damage, rhabdomyolysis, kidney failure, and death. Co-administration of Rosuvastatin with Gemfibrozil resulted in a 2-fold increase in Rosuvastatin AUC and Cmax above the normal range. There is an increased risk of muscle damage when Rosuvastatin is used concomitantly with gemfibrozil, other fibrate-lowering agents, and high-dose niacin because these drugs can cause myopathy even when used alone. The first dose of Rosuvastatin should be started at 5 mg. Concomitant use of Rosuvastatin with Colchicine increases the risk of muscle damage. When co-administering Rosuvastatin 10mg with Ezetimibesex, the AUC of Rosuvastatin doubled in patients with hypercholesterolemia. Co-administration of Rosuvastatin with aluminum-containing antacids, magnesium hydroxide increases plasma concentrations of Rosuvastatin by approximately 50%. Erythromycin given with Rosuvastatin increases the UAC and Cmax of Rosuvastatin by 20% and 30% and may increase the effect of Erythromycin on intestinal motility. Results of in vitro and in vivo assays indicate that Rosuvastatin neither inhibits nor induces cytochrome P450 isoenzymes. Therefore, there are no interactions with drugs mediated by Cytochrome P450 and no clinical interactions between Rosuvastatin and Ketoconazole and Fluconazole have been observed. The above is not a complete list of all drug interactions that may be encountered when using Rosu 5 Tablet with other drug lines. Therefore, to ensure patient safety, please list all the current medications and other medical conditions for the doctor to have a reasonable medication direction.
7. Notes during the use of Rosu 5 Tablet
Rosu 5 Tablet is not recommended in pregnant women, should use appropriate contraception while taking Rosuvastatin. Because cholesterol and the products of cholesterol biosynthesis are necessary for the development of the fetus. If the patient is pregnant, treatment with Rosuvastatin should be discontinued immediately. Rosuvastatin should not be used by women who are breastfeeding. The side effects of Rosuvastatin can be dizziness, so use caution while driving and operating machinery. Cases that need to be noted before taking Rosu 5 Tablet: elderly people, children under 15 years old, people with kidney/liver failure, people who are allergic to Rosuvastatin or excipients in the drug, people with myasthenia gravis. , liver coma and stomach ulcers. Hopefully with the information provided above, patients can have more useful information about the Rosu 5 Tablet line. Patients should always strictly follow the medication instructions and instructions from the doctor, pharmacist before using Rosu 5 Tablet, absolutely do not buy the drug at home and self-treat it will cause side effects. Side effects do not want to affect health.
Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
