This is an automatically translated article.
Ribometa medicine 4mg/5ml (zoledronic acid) is a bisphosphonate, acting mainly on bone. The drug is an inhibitor of osteoclast-mediated bone resorption. The following article gives readers a clear understanding of the effects of the drug.
1. What is Ribometa 4mg/5ml?
Ribometa 4mg/5ml belongs to a group of medicines called 'bisphosphonates' used to treat osteoporosis (weak and brittle bones) caused by menopause or long-term steroid use. Treatment of bones and high calcium levels caused by cancer.
Osteoporosis is a bone disease that weakens and thins bones due to a decrease in bone density. This condition is common in postmenopausal women, or the elderly...
Ribometa 4mg/5ml contains Zoledronic acid which works by binding tightly to bone and preventing the removal of calcium by osteoclasts. (a type of bone cell that destroys bone tissue). This prevents osteoclasts from breaking down bone and keeps bones strong and reduces the risk of fractures.
2. How to use Ribometa 4mg/5ml
The doctor or nurse will inject Ribometa 4mg/5ml intravenously (IV). In some cases, you may experience headache, fever, nausea, dizziness, vomiting, back pain, diarrhea, muscle, joint or bone pain, and swelling or pain at the injection site in some cases. Most of these side effects of Ribometa 4mg/5ml do not require medical attention and will usually improve after a period of discontinuation.
However, if the side effects persist or worsen, please consult your doctor.
3. Uses of Ribometa 4mg/5ml
Ribometa medicine 4mg/5ml is effective in the treatment of the following diseases:
Treatment of postmenopausal osteoporosis Treatment of hypercalcemia (high calcium levels) in cancer Treatment of bone cancer Treatment of Paget's disease Ribometa 4mg drug /5ml binds tightly to bone and prevents calcium removal by osteoclasts (a type of bone cell that destroys bone tissue). This prevents osteoclasts from breaking down bone, keeping bones strong and reducing the risk of fractures.
In addition, Ribometa 4mg/5ml can reduce blood calcium levels by preventing the reabsorption of calcium from the bones into the blood. Therefore, it helps to treat high blood calcium levels caused by cancer.
4. Dosage and indications of the drug Ribometa 4mg/5ml
Intravenous dosing (eg, Zometa or generic equivalents): 4mg IV over a minimum of 15 minutes. Treatment may be considered if serum calcium has not returned to normal after 7 days. Monitor serum creatinine at each dose.
Intravenous Dose in Adults: 4mg IV infusion at least every 15 minutes every 3 to 4 weeks. Oral calcium supplement 500mg and vitamin D 400.
Monitor serum creatinine (SCr) at baseline and with each subsequent dose. If renal function worsens (that is, SCr increase by 0.5 mg/dL or more for normal SCr at baseline or 1 mg/dL or more for abnormal SCr at baseline), keep dose until renal function is within 10% of baseline. Restart with the same dose used before stopping treatment.
4.1. For the treatment of Paget's disease Intravenous dosage: 5mg IV over at least 15 minutes as a single dose. All patients should take 1,500 mg of elemental calcium daily in divided doses (750 mg twice daily or 500 mg three times daily) and 800 vitamin D daily, particularly for 2 weeks after dosing. .
4.2. For the treatment of osteoporosis Treatment of osteoporosis in postmenopausal men or women. Intravenous dosing in adult men and postmenopausal women: 5 mg IV over at least 15 minutes, once a year. Add calcium and vitamin D if the diet is not enough. The optimal duration of treatment has not been determined; Reassess treatment on a periodic basis.
For patients at low or moderate fracture risk, consider discontinuing zoledronic acid after 3 to 5 years. After discontinuation of treatment, continue to periodically reassess fracture risk. Continue taking zoledronic acid for up to 6 years in postmenopausal patients who are initially at very high risk of fracture.
4.3 For Corticosteroid-induced Osteoporosis In Men and Women Intravenous Dose: 5mg IV infusion over at least 15 minutes, once a year. If dietary intake is insufficient, supplement with calcium and vitamin D daily. An average of at least 1,200 mg of calcium and 800 to 1000 vitamin D is recommended per day. For use in patients receiving systemic corticosteroids. Optimal duration of treatment has not been determined, reassess treatment periodically.
For patients at low fracture risk, consider discontinuing zoledronic acid after 3 to 5 years. After discontinuation of treatment, continue to periodically reassess fracture risk. According to guidelines, use only in patients at moderate to high fracture risk, not recommended if fracture risk is low.
5. Drug interactions Ribometa 4mg/5ml
Ribometa 4mg/5ml can interact with antibiotics (gentamicin) and water pills (furosemide).
Avoid taking Ribometa 4mg/5ml if you have hypocalcemia (low level of calcium in the blood) and severe kidney problems. If you have cancer, gum disease, poor oral health or are planning to have a tooth extracted or have kidney problems, tell your doctor before taking ribomet 4mg/5ml.
In addition to taking the initiative to take the drug at the right dose, the patient should also have a healthy diet and lifestyle to get the best results for the treatment process.
Hopefully with the sharing of the drug Ribometa 4mg/5ml will help you understand and have a more effective medication process.
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