Uses of Rezurock

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1. What does Rezurock do?

Belumosudil in Rezurock is an inhibitor of kinase, an enzyme that promotes cell growth.
Rezurock is a targeted therapy through its ability to inhibit a protein called “Rho kinase 2” or “Rho-linked coil kinase 2” (ROCK-2 for short). Rezurock inhibits the action of ROCK-2 in cells, thereby blocking the signaling and anti-inflammatory pathways induced by ROCK-2. Rezurock is used to treat chronic graft-versus-host disease (cGvHD) in adults and children over 12 years of age after failure of at least 2 prior systemic therapies.

2. How to use Rezurock

Rezurock is in the form of tablets, taken orally once a day after meals with a full glass of water. The patient should swallow the Rezurock tablet whole instead of crushing, chewing, or biting the tablet. Patients should take Rezurock at the same time each day, 24 hours apart. If a dose of Rezurock is missed, the patient should take the missed dose as soon as possible the same day and return to their normal schedule the next day, taking care not to take an extra dose to make up for the missed dose.
Patients should talk to their doctor if there is a personal history of kidney or liver function problems. Your doctor should order a blood test at least once a month while taking Rezurock to check a patient's liver function.
Blood levels of Rezurock can be affected when patients take certain foods and drugs together, so refer to the instructions for use to avoid those drugs. Patients should inform their doctor of all medications and supplements they are taking.

3. Side effects of the drug Rezurock

3.1. Decreased white blood cell count and increased risk of infection Rezurock can lead to some serious life-threatening infections, with or without a decrease in the white blood cell count.
White blood cells are blood cells that play an important role in fighting infections. During treatment with Rezurock , a person may experience a decrease in white blood cell count and lead to a higher risk of infections. Patients should contact their doctor immediately if they develop symptoms of an infection such as fever, sore throat, signs of a cold, cough, difficulty breathing, burning in the urinary tract, or slow healing of sores.
Some doctor's tips to help prevent infection when using Rezurock :
Wash your hands often to prevent the spread of bacteria and viruses; Limit going to crowded places to avoid contact with people with contagious diseases; When working should wear protective clothing; Do not handle pet waste with bare hands; Keep skin wounds or scrapes clean at all times; Personal hygiene and regular oral care; Talk to your doctor before getting any vaccines. 3.2. Nausea, vomiting Your doctor may prescribe medications to control this side effect of Rezurock . In addition, patients can change their diet and avoid factors that trigger vomiting.
3.3. Electrolyte disturbances Rezurock may affect the normal levels of electrolytes (such as phosphate, potassium, calcium...) in the body. Therefore, testing of the levels of important electrolytes should be performed for monitoring during Rezurock treatment. If electrolyte levels are too low, your doctor may prescribe intravenous or oral supplements.
3.4. Decreased Platelet Count Platelets help the body's blood clotting process, so when the count is too low, it increases the risk of abnormal bleeding. Tell your doctor if you experience bruising or persistent bleeding, including nosebleeds, bleeding teeth, or bloody urine.
3.5. Anemia due to a decrease in the number of red blood cells Red blood cells are blood cells responsible for carrying oxygen to the tissues in the body. Anemia or low red blood cell count will make the patient often tired or weak.
3.6. Diarrhea The oncologist can recommend medications to relieve diarrhea for people taking Rezurock . In addition, patients can change the diet, reduce fiber supply, avoid fresh fruits, vegetables, whole grain breads, cereals and seeds... can be helpful. Besides, soluble fiber has the ability to absorb liquid which can help treat diarrhea. Foods rich in soluble fiber include: apple sauce, bananas (ripe), canned fruits, oranges, boiled potatoes, white rice, products made from white flour... Patients should pay attention to supplements. Drink enough water, limit alcohol or caffeinated drinks to prevent dehydration.
3.7. Shortness of breath, cough Some people taking Rezurock may experience shortness of breath or cough (new-onset or more severe than before). If there is difficulty breathing or coughing, the patient should notify the treating physician.
3.8. Peripheral edema Peripheral edema is swelling of the limbs due to fluid retention, which can occur in the hands, arms, legs, ankles, and feet. Patients should inform their doctor if swelling occurs at any location.
3.9. Abdominal pain Rezurock may cause abdominal pain in patients. Call your doctor if the pain becomes severe, or it makes it difficult to eat or perform daily activities.
3.10. Bleeding Patients may experience minor bleeding, such as nosebleeds. Serious bleeding has also occurred in patients treated with Rezurock, including hemoptysis, stomach bleeding, bloody diarrhea, hematemesis, brain bleeding (stroke), and hematuria. People who already have a history of severe bleeding should not take Rezurock. These side effects are not common, however when they do occur it is imperative to stop using Rezurock. Patients should notify their doctor immediately if bleeding of any kind occurs.
3.11. Musculoskeletal pain, headaches Your doctor may recommend medications and other strategies to help relieve pain from taking Rezurock.
3.12. High blood pressure Rezurock can cause a person's blood pressure to rise. Patients should have their blood pressure checked regularly during treatment with this product. Any hypertensive condition requires appropriate treatment. If hypertension is not controlled, the patient may have to discontinue Rezurock.

4. Rezurock's Fertility Concerns

Exposure of the fetus to Rezurock can lead to birth defects, so patients should not have children while taking Rezurock. Using effective birth control is essential during and for at least 1 week ending treatment with Rezurock.
This medicine may affect a patient's fertility, so they may consider using a sperm or egg bank if they want to have children in the future.
Patients should not breast-feed while taking Rezurock and for at least 1 week after the last dose.

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Reference source: oncolink.org