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Relotabin is an anti-cancer drug used in the treatment of breast cancer, colorectal cancer, ... So how to use Relotabin? Let's find out the necessary information about the drug Relotabin through the article below.
1. What is Relotabin?
The drug Relotabin is an anti-cancer drug.
Pharmaceutical name: Relotabin Classification: Drug Registration number: VD-20515-14 Drug group: Anti-cancer drug Manufacturer: SPM Joint Stock Company Ingredients: Capecitabin 500mg Excipients in sufficient dosage Form: Tablets film bag Packing: Box of 3 blisters x 10 tablets
2. The effect of the drug Relotabin
Relotabin is indicated for the treatment of:
Metastatic colorectal cancer (step one) Adjuvant treatment of stage III colon cancer after surgery Advanced breast cancer after failure of chemotherapy Combination Docetaxel treatment Treatment of advanced breast cancer after failure of chemotherapy. First-line combination therapy for advanced gastric cancer.
3. Contraindications to using Relotabin
Subjects not allowed to use Relotabin:
Hypersensitivity to Relotabin drug ingredients. History of serious adverse reactions during treatment with fluoropyrimidine. Pregnant and lactating women. Severe renal impairment (ClCr < 30 mL/min). Are being treated with Sorivudin or a chemically similar substance such as Brivudin. Dihydropyrimidine dehydrogenase deficiency. Leukopenia, neutropenia, severe thrombocytopenia. Severe liver failure. Are taking the complex form of Tegafur, Gimeracil, Oteracil potassium or within 7 days after stopping the drug. Should not be used in patients with galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
4. Dosage and how to use Relotabin
How to use Relotabin:
Should take Relotabin with food Drink with water within 30 minutes after eating Read carefully the instructions on how to take Relotabin from the drug user manual, do not arbitrarily use the drug by other routes not listed on the leaflet for use of Relotabin.
Dosage of Relotabin:
Colorectal cancer, breast cancer: 1250mg/m2 x 2 times/day (morning & evening) for 2 weeks, then stop taking Relotabin for 1 week in a 3-week cycle. Combination therapy:
Breast cancer: 1250mg/m2 x 2 times/day for 2 weeks, then stop taking Relotabin for 1 week, and docetaxel 75mg/m2 as an intravenous infusion within 1 hour every 3 weeks. Pre-prepare oral corticosteroids prior to administration of Docetaxel. Colorectal cancer: 1000mg/m2 x 2 times/day for 2 weeks, then stop taking Relotabin for 1 week, combine with Oxaliplatin 130 mg/m2 intravenously within 2 hours on the first day every 3 weeks, within 24 weeks. Prepare an antiemetic before taking Oxaliplatin. Stomach cancer: 1000 mg/m2 x 2 times/day for 14 days, then stop the drug for 7 days, combine with Cisplatin 80 mg/m2 intravenously for 2 hours every 3 weeks; or 625 mg/m2 x 2 times/day continuously for 3 weeks, a combination of cisplatin 60mg/m2 IV infusion over 2 hours and Epirubicin 50mg/m2 IV rapidly every 3 weeks. Prepare in advance to secure fluids and antiemetics before taking Cisplatin. Patients with moderate renal impairment: reduce dose to 75% with an initial dose of 1250 mg/m2. How to use drink with water within 30 minutes after eating.
5. Relotabin side effects
Nausea, vomiting, loss of appetite, constipation, fatigue, weakness, headache, dizziness, trouble sleeping, or changes in taste may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or reduce nausea and vomiting. Diarrhea is a common side effect of Relotabin. Drink plenty of fluids unless otherwise directed. Your doctor may also prescribe medication (such as loperamide) to help relieve diarrhea. Vomiting or diarrhea that doesn't stop can lead to severe body dehydration (dehydration). Contact your doctor right away if you notice any symptoms of dehydration, such as decreased urination, dry mouth/thirst, or lightheadedness/dizziness. Hair loss, temporary nail changes may occur. Using Relotabin can have serious side effects. However, the doctor weighed the benefits above the risk of side effects. Needing to be monitored by a doctor may reduce the risk. Stop taking Relotabin and tell your doctor right away if any of these serious side effects occur: severe nausea/vomiting (vomiting 2 times/day, inability to eat or keep food/liquid in the stomach). ), skin redness/swelling/pain in your mouth or on your tongue. For men and women of childbearing age, Relotabin may affect your ability to have children. Ask your doctor for more details. Relotabin may decrease your ability to fight infections. Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, mental/mood changes (such as depression), swelling ankles/legs, vision changes , signs of kidney problems (such as change in the amount of urine), yellow eyes/skin, dark urine. Very serious allergic reactions to Relotabin are very rare. However, get medical help right away if you experience symptoms of a serious allergic reaction such as: rash/urinary blisters/skin peeling, itching/swelling (especially of the face/tongue/throat), severe dizziness severe, difficult to breathe. This is not a complete list of possible side effects. If you notice other side effects not listed above, contact your doctor or pharmacist.
6. Precautions, warnings and notes when using Relotabin
Caution, warning:
Relotabin can cause a lot of side effects, only used when prescribed by a doctor. Special note for people: allergic to the ingredients of Relotabin, children, the elderly, pregnant women, people with liver - kidney disease. Patients should be closely monitored while using Relotabin.
Note:
Note taking Relotabin during pregnancy
General note during pregnancy: Relotabin used during pregnancy can cause bad effects (miscarriage, teratogenicity, malformations, etc.) fetus,...) to any stage of pregnancy, especially the first trimester. Therefore, it is best not to use Relotabin in pregnant women. In the case of mandatory use, it is necessary to consult carefully with your doctor, pharmacist before making a decision.
Precautions for taking Relotabin during breastfeeding It is best not to or limit the use of Relotabin during breast-feeding. Many drugs have not yet fully determined the effects of the drug during this period, so mothers need to carefully read the instructions for use and consult with doctors and pharmacists before deciding to use the drug.
7. Drug interactions
When using two or more drugs at the same time Relotabin often occurs drug interactions leading to the phenomenon of antagonism or synergism.
Drug interactions Relotabin with other drugs
Capecitabine causes serious interactions with some of the following drugs:
Anticoagulants Coumarin Cytochrome P-450 2C9 substrate Phenytoin Bevacizumab Antacids Sorivudine and Oxaliplatin analogues Leucovorin (folinic) acid) Drug interaction Relotabin with food, drink
When using Relotabin with foods or alcohol, beer, tobacco... because in those foods and drinks contain other active ingredients, so may have an antagonistic or synergistic effect on the drug. Read the instructions for using Relotabin carefully or consult your doctor or pharmacist about taking Relotabin with food, alcohol and tobacco.
8. Preservation of drugs
Relotabin medicine is stored at room temperature, away from moisture and light. When Relotabin is past its expiration date or cannot be used, consult your doctor, pharmacist or garbage disposal for a safe way to dispose of it. Relotabin should not be thrown into the toilet or plumbing unless directed to do so. Keep Relotabin out of the reach of children and away from pets. Before using Relotabin, it is necessary to double-check the expiry date indicated on the product packaging, especially with medicines stored at home.
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