This is an automatically translated article.
Rejina drug is effective in the treatment of endocrine disorders and has anti-inflammatory effects. The drug is also used in the treatment of arthritis, enteritis, bronchitis, rhinitis, allergic eye inflammation. However, in the course of drug treatment can cause some side effects such as nausea and vomiting, headache, muscle weakness... Therefore, patients should learn carefully the information.
1. Mechanism of action of the drug Rejina
What is Rejina medicine. Glucocorticoids cross the body's cell membranes and bind to specific receptors in the cytoplasm. These complexes will enter the cell nucleus and bind to DNA, thereby stimulating the transcription of messenger RNA. Therefore, it will affect the protein synthesis of different enzymes that are essential in the formation of the systemic effects of glucocorticoids. The maximum pharmacological effects of corticosteroids usually appear after peak drug concentrations. Most of the drug's effects are the result of an effect on enzyme activity rather than the direct effect of the drug
Rejina is rapidly absorbed from the gastrointestinal tract and peaks after one hour of administration. More than 90% of the drug when entering the body is bound to plasma proteins.
Maximum plasma concentrations of Rejina can be reached in 30 to 60 minutes. And about 40 to 90% of the drug is bound to plasma proteins.
2. Indications and contraindications for using Rejina
Rejina is indicated in the treatment of endocrine disorders, primary or secondary adrenal insufficiency, joint disease with post-traumatic osteoarthritis, bursitis or rheumatoid arthritis, acute bursitis or subacute, condylar conjunctivitis, acute nonspecific tenosynovitis...
However, Rejina may be contraindicated in some cases of hypersensitivity to the drug's components, systemic fungal infections, and women. pregnant and nursing
3. Dosage and how to use Rejina
Dosage of Rejina is recommended with an initial dose of 100 to 150mg or can be increased in case of a doctor's prescription. Doses should be repeated in 2, 4 or 6 hours depending on individual patient response. However, it is advisable to ensure that the dose of Rejina according to body weight is not less than 25 mg per day and a maximum of 15 mg/kg per day. signs and symptoms of adrenal insufficiency. Because corticosteroids are only supportive therapy, not replacement therapy.
Note: The above recommended therapeutic dose for Rejina is for reference only. Therefore, before using Rejina, patients need to follow the doctor's instructions.
4. Side effects when using Rejina
Rejina may cause some unwanted side effects during treatment. However, with each case of Rejina drug side effects can occur in varying degrees from mild to severe.
Some common side effects caused by Rejina include: nausea and vomiting, fatigue, muscle weakness, skin bruising... These side effects may occur at the start of treatment or after increasing the dose. amount of Rejina drug. Usually, side effects from Rejina can be transient or subside over time.
However, in some cases Rejina can cause serious unwanted side effects with rare reactions. These reactions may appear within minutes of using Rejina or longer within a few days. When serious side effects such as: sodium retention, potassium loss, osteoporosis, bone fractures, stomach bleeding, increased intracranial pressure, etc., patients should stop using Rejina and go to a medical facility. for immediate medical assistance.
Some notes in the process of using Rejina:
Rejina can change the ability to work as well as increase the effect of side effects. Therefore, to avoid drug interactions, the patient should provide the doctor with a list of previously used drugs, including prescription and non-prescription drugs, herbs,... Medicines that affect alertness user's. Therefore, if the sick Rejina people often have to perform the work of operating machinery or driving a car that requires high concentration, care should be taken when using Rejina. Above is important information about Rejina medicine, patients should carefully read the instructions for use and use according to the dose prescribed by the doctor to get the best effect.
