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Raxiz is a psychotropic drug used in the treatment of infantile spasms or partial seizures. So what does Raxiz do? In what cases is the drug indicated? And how can the drug be used effectively and safely for the patient?1. What is Raxiz?
Raxiz is a drug on the ETC prescription drug list. The main ingredient of the drug is Vigabatrin 500mg. In which, Vigabatrin is an anticonvulsant drug used in the treatment of epilepsy or antiepileptic. The drug can be used for both adults and children over 1 month old. In neonates, the drug is used as monotherapy in the treatment of spasms (West syndrome).
Once in the body, Vigabatrin acts as a selective, irreversible inhibitor of GABA-transaminase. Taking Vigabatrin correctly and in sufficient doses increases the concentration of GABA and inhibitory neurotransmitters in the brain. Therefore, the drug is very effective in patients with partial seizures.
2. What does Raxiz do?
Indications for use of Raxiz drug in the following cases:
As an adjunct to the treatment of patients over 10 years of age with persistent complex partial seizures that have not responded to other alternative therapies. Treatment of spasms in children between the ages of 1 month and 2 years. However, for this stage, it is necessary to weigh the benefits and harms when using the drug because Raxiz can cause the risk of vision loss for children. Raxiz is contraindicated in patients with a history of allergy or hypersensitivity to any of the ingredients and who have a history of or are being treated for psychiatric disorders.
3. Usage and dosage of the drug Raxiz
Raxiz is made in the form of long film coated tablets. Each box contains 3 blisters, each blister contains 10 tablets. The drug is used mainly orally. The time of taking the drug is not related to the patient's meal.
The recommended dosage of the drug is as follows:
For the treatment of persistent complex partial seizures: People over 16 years: Oral starting dose of 1000mg/day in 2 divided doses. It is recommended for adults to take 3000mg/day in 2 divided doses. Children from 10 to 16 years old: It is recommended to start with 500mg/day in 2 divided doses and gradually increase the dose to 2000mg/day in 2 divided doses. Note that in children weighing more than 60kg, the dose is equivalent to the dose of people over 16 years old. Treatment of spasms in children in the period from 1 month to 2 years: The starting dose is 50mg/kg/day divided into 2 times. Every 3 days, gradually increase the dose by 25-50mg/kg/day, up to a maximum of 150mg/kg/day. Treatment of West syndrome in neonates with an initial dose of 50 mg/kg/day in 2 divided doses. Adjust dose after 1 week if necessary. Use in patients with renal impairment: The dose depends on the creatinine clearance at the same time interval. If creatinine clearance is between 50 - 80ml/min: reduce dose by 25%. If creatinine clearance is in the range of 30 - 50 ml/min: reduce dose by 50%. If creatinine clearance is in the range of 10-30ml/min: reduce dose by 75%.
4. Side effects and notes when using Raxiz
Some possible side effects when using Razix:
The drug may cause drowsiness, dizziness, may be shaking uncontrollable part of the body, reducing the ability to coordinate flexibility between areas. . Feeling tired, pale skin, pain in some joints or muscles. Affects the patient's memory and thinking, or is confused. Swollen hands and feet, possibly swelling of the feet, ankles and legs, tingling in the hands with pain. Gastrointestinal disorders: diarrhea or constipation, vomiting, nausea, abdominal pain, sometimes heartburn. Female patients may experience menstrual cramps. Shortness of breath, rapid heartbeat, hives on the skin. In order to limit the occurrence of side effects, when taking the drug, it is necessary to note the following:
Use the medicine according to the instructions and instructions of the specialist. Do not arbitrarily increase or decrease the dose of the drug without the permission of the doctor. Using the drug in children, calculate the dose based on the child's body weight. It is advisable to start with a low dose and then gradually increase the dose to limit the risk of unwanted effects such as drowsiness. Discontinuation of the drug also requires gradual dose reduction, not abrupt discontinuation. In pregnant women, experts say the drug can cause miscarriage. congenital malformations of the fetus, especially in the first 3 months of life. Therefore, the drug should not be used in these subjects. In case you must take medicine, consult your doctor, weigh the benefits and harms. Several studies have shown that Raxiz is likely to pass into breast milk. Therefore, it is not recommended to use the drug in nursing mothers. The drug can cause drowsiness, so it should be used with caution in people who have to drive or operate machinery. Do not share the drug with alcohol, tobacco or other stimulants. In case of overdose, it is necessary to immediately contact a specialist for advice on timely handling. Some symptoms may be encountered when using Raxiz overdose such as drowsiness, even loss of consciousness. Patients need to go to the nearest medical facility for emergency treatment if there are signs of shortness of breath, coma. If you miss a dose, take it as soon as you remember it, preferably 1 to 2 hours after the time your doctor prescribes. Skip the dose if it is too close to the time for the next dose. In particular, do not take a dose after doubling the dose to make up for a missed dose. In general, Raxiz is effective in improving the symptoms of partial seizures. However, the drug has many side effects, so you need to be careful when using it. Consult your doctor before use for advice on how to use the drug safely and effectively.
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