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Carbamazepine is indicated in the treatment of generalized/partial epileptic seizures, with analgesic effect due to trigeminal nerve or lingual nerve - almost... Precautions when using Carbamazepine 200mg.
1. General information about the drug Carbamazepine
Carbamazepine is prepared in the following forms:
Tablets: Carbamazepine 200mg; Chewable tablet form: Carbamazepine 100mg; Slow-release tablets with the strength of 100mg/ 200mg/ 400mg; Oral suspension form with the content of 100mg/5ml; Tablets placed rectally with a strength of 125mg / 250mg. 1.1. Indications for the use of Carbamazepine Treatment of epilepsy: Partial seizures with complex symptoms such as psychomotor and temporal lobe epilepsy; Treatment of acute manic episodes and maintenance of bipolar affective disorders to prevent or reduce recurrence; Treatment of alcohol withdrawal syndrome; Support the treatment of people with idiopathic trigeminal neuralgia and trigeminal neuralgia due to complications of multiple sclerosis; Treatment of neuropathy in patients with diabetes mellitus; Treatment of central diabetes insipidus, polyuria and polydipsia of neurohormonal origin. 1.2. Dosage and Administration of Carbamazepine: Patients prescribed carbamazepine treatment must be started at a low dose, then gradually increased over a period of time until the maximum effect of the drug is achieved.
In case of treatment of patients with epilepsy:
Dosage for adults:
The first phase of treatment with a dose of 100-200mg, used 1-2 times a day. The dose is gradually increased as the maximal response is reached (in the range of 400 mg, administered 2-3 times a day), in some cases increasing the dose to 1600 mg or even 2000 mg/day as directed by the physician. Dosage for children:
Under 1 year: Use Carbamazepine 100mg or Carbamazepine 200mg in 1 day; Children from 1 to 5 years old: Use Carbamazepine 200mg to 400mg/day; Children from 6 to 10 years old: Use Carbamazepine 400 to 600mg/day; Children from 11 to 15 years old: Use Carbamazepine 600 to 1000mg/day. For children 4 years of age or younger, treatment is usually started at a dose of 20-60mg/day. In case of treatment of patients with neuralgia V:
Usually indicated starting dose from 200 to 400mg/day. The dose will be gradually increased until the pain is gone (common dose is 200mg x 3-4 times/day). After stabilization, the dose should be gradually reduced to the lowest possible maintenance dose. For the elderly, the starting dose is 100mg twice a day. In case of treatment of patients with alcohol withdrawal syndrome:
The average dose used is 200 mg x 3-4 times/day. If the patient has severe alcohol withdrawal syndrome, the dose should be increased on the first days, up to 400mg 3 times/day. For high-dose treatment cases, it is necessary to combine Tegretol with sedatives/hypnotics such as Clomethiazol, Chlordiazepoxide. Once the patient has passed the acute phase, monotherapy is indicated to continue with Tegretol. In case of treatment of patients with manic episodes and prevention of manic - depressive states (bipolar state):
Dosage is usually indicated in the range of 400 - 600 mg / day divided into 2 - 3 times. In the case of an acute manic episode, the dose should be increased rapidly. For the preventive treatment of bipolar affective disorder, the dose should be increased slightly to achieve best tolerability.
2. Precautions when using Carbamazepine
Contraindicated to use Carbamazepine in the following cases:
Patients with signs of atrioventricular - ventricular conduction disorders; Patients with a history of bone marrow failure; The patient is being treated for porphyria; Patients with hypersensitivity to carbamazepine or tricyclic antidepressants. Use caution when using Carbamazepine in the following cases:
Patients with liver failure, kidney failure; Patients with heart diseases; Patients with a history of hematological disorders (blood counts must be monitored before and during treatment); Patients with skin reactions; Patients with glaucoma; Patient is pregnant or breastfeeding. When using Carbamazepine, it is necessary to avoid abrupt discontinuation, do not use concomitantly with monoamine oxidase inhibitors (MAOIs), and use Carbamazepine only after at least 15 days of discontinuation of MAOIs.
Side effects when taking drugs
Neurological signs: Dizziness, headache, ataxia, somnolence, fatigue, double vision syndrome; Digestive disorders: The patient feels abdominal pain, nausea, vomiting; On the patient's skin signs of allergy appear; Hematological disorders: Leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia; Liver diseases: Hepatitis, jaundice, cholestasis,...; Cardiovascular diseases: Cardiac arrhythmia, increased or decreased blood pressure, thrombophlebitis,...; Diseases of the urinary tract - genital organs: Inflammation or failure of the kidneys, signs of impaired kidney function, sexual disorders; Sensory diseases: Taste disorders, cataracts, conjunctivitis,...; Musculoskeletal diseases: Joint pain, muscle pain, cramps,...; Stevens Johnson Syndrome. These adverse events were more frequent in patients receiving combination therapy with Tegretol and high initial doses, or in the elderly.
Carbamazepine is a prescription drug, so make sure you consult your doctor before using it. Hopefully the article has provided you with useful information about the uses, doses and precautions when using Carbamazepine.
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