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Ravenell-125 drug with the main ingredient is Bosentan, which is made in the form of film-coated tablets. The drug is indicated for the treatment of pulmonary hypertension. Let's understand the uses of Ravenell-125 and important notes when using it in the article below.
1. What is Ravenell 125?
Ravenell 125 has the main ingredient Bosentan (in the form of Bosentan monohydrate) 125mg with other excipients just enough for 1 tablet.Packing: Box of 4 blisters × 14 tablets Dosage form: Film-coated tablets Manufacturer: Dat Vi Phu Pharmaceutical Joint Stock Company (DAVIPHARM) – VIETNAM Registration number: VD-31091-18 Ravenell 125 It is a prescription drug indicated for the treatment of patients with pulmonary hypertension. The main ingredient Bosentan in the drug works to block the effects of Endothelin - 1 (ET-1). This is a hormone that causes blood vessels to narrow, in addition to promoting fibrosis. Thereby, using bosentan as a drug to help dilate blood vessels, increase cardiac output without causing an increase in heart rate.
2. Uses of Ravenell 125
Ravenell 125 is indicated for use in the treatment of:
Pulmonary hypertension: The amount of oxygen supplied to the blood from the lungs decreases, thereby making it difficult for normal physical activities. Using Ravenell 125 will help dilate the pulmonary arteries, making it easier to carry blood from the heart to the pulmonary arteries. Thereby helping to lower blood pressure, reduce fatigue, shortness of breath and reduce the rate of bad clinical complications. Scleroderma patients: Ravenell 125 will reduce the number of new sores on the fingers or feet.
3. Dosage and treatment
3.1. Dosage How to use: Ravenell 125 is prepared in the form of film-coated tablets, so patients can take it orally as prescribed by the doctor in the morning and evening. The drug can be taken with or without food.
Dosage:
For adults: Depending on the response of each body, the doctor will prescribe the drug 2 times a day. Before that, the doctor will prescribe oral Ravenell 62.5 mg for the first 4 weeks to ensure safety and use the above dose (depending on the condition). For children: The drug only applies to children with pulmonary hypertension. Medicines do not treat children with scleroderma. Children 1 year of age and older are usually prescribed a dose of 2mg/kg twice a day. For young children, do not self-medicate and require specific instructions from a doctor. 3.2. Treatment of missed dose, overdose Overdose:
In case of using Ravenell 125 in excess of the prescribed dose and having unusual symptoms, it is necessary to immediately contact the nearest medical facility. In addition, family members should also bring any medications the patient has been using or a medical examination book so that the doctor can make a timely diagnosis and treatment.
Missed dose:
During the use of Ravenell 125, patients need to follow the doctor's treatment schedule, to avoid the occurrence of missed doses that reduce the effectiveness of treatment. If you miss a dose of Ravenell 125, use the missed dose as soon as you remember. But if it is too close to the next dose, skip the missed dose and take the next dose as scheduled. Patients should not double the dose of Ravenell 125, because it can cause an overdose. To overcome missed dose, patients can set an alarm or ask a loved one to remind them.
4. Side effects of Ravenell 125
During the use of Ravenell 125, there may be some specific side effects as follows:
Serious: Encounter liver function problems such as nausea, vomiting, abdominal pain, itchy skin, jaundice, dark urine,... That leads to anemia, requiring additional blood transfusion if the case is dangerous. Very common: Headache, edema Common: Facial flushing, nervousness, palpitations, severe hypotension possibly syncope, hypersensitivity reactions, gastroesophageal reflux, diarrhea, .. Uncommon: Anemia, jaundice, yellow eyes,... Rare: Anaphylaxis, angioedema, liver failure,...
5. Notes when using Ravenell 125
5.1. Contraindications Contraindicated to use Ravenell 125 in the following cases:
Patients with a history of allergy to Bosentan or any of its ingredients. Pregnant women. Patients are using Cyclosporin A because concomitant use of the drug with Ravenell 125 will occur drug interactions. Concurrent use of glyburic drugs: Concomitant use of Ravenell 125 increases the risk of increased liver enzymes. Patients with and being treated for moderate or severe liver failure, patients with high aminotransferase. People with low blood pressure. Women during lactation. History of anemia or heart disease should be discussed with your doctor. 5.2. Precautions when taking the drug During the use of Ravenell 125, patients should pay attention to the following issues:
Absolutely do not arbitrarily use Ravenell-125 for children who are suffering from scleroderma and are showing signs of scleroderma. To ensure safety and good treatment results, the doctor will order the patient to do the following tests: Blood test, liver function test, pregnancy test,... During treatment with With the drug Ravenell-125, doctors will still give users periodic blood tests to monitor liver function and anemia. Your doctor will advise you to reduce the dose or stop the drug treatment if the test results are abnormal. Do not use the drug to treat low blood pressure (systolic less than 85 mmHg). Bosentan can cause hypotension, so it is necessary to monitor blood pressure during use. In the excipients of the drug Ravenell-125 contains castor oil, this oil can cause nausea, vomiting, abdominal pain, diarrhea. . Therefore, patients should be careful when using the drug. Do not use the drug for pregnant women because there have been studies showing that bosentan is teratogenic in rat Ravenell-125, which can affect liver, kidney, and heart function in humans. Elderly patients should be cautious when using the drug in elderly patients It is not recommended to stop the dose suddenly, but to reduce the dose gradually.
6. Drug interactions
Possible drug interactions when taking Ravenell-125 are:
Cyclosporin A: Co-administration of bosentan is contraindicated because studies have shown that when these two drugs are used together, bosentan blood levels are high. will increase about 3 to 4 times. Fluconazole: These two drugs should not be used because fluconazole is an inhibitor of CYP2C9, resulting in a significant increase in bosentan concentrations. Sirolimus or tacrolimus: Do not co-administer bosentan as it may increase the plasma concentrations of sirolimus or tacrolimus. Glibenclamide, rifampicin, nevirapine: Although there are no data on drug interactions when co-administered with bosentan, patients should consult their doctor and monitor their body condition when taking these drugs simultaneously. Hormonal contraceptives: When used with Ravenell-125, the contraceptive effect will no longer be effective During the use of Ravenell-125, patients should pay attention to follow the doctor's instructions, carefully read the instructions Care should be taken before use to maximize the effectiveness of treatment and limit possible side effects.
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