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Pyzacar HCT has the main ingredients losartan potassium and Hydrochlorothiazide, a drug used in the treatment of hypertension. Patients need to take the drug exactly as directed by the doctor to avoid unwanted consequences.
1. What is Pyzacar HCT?
What is Pyzacar HCT? Pyzacar HCT contains losartan potassium and hydrochlorothiazide as the main ingredients. Losartan belongs to the class of antihypertensive drugs, angiotensin II receptor antagonists. Hydrochlorothiazide belongs to the group of thiazide diuretics.
2. Indications of Pyzacar HCT
Pyzacar HCT is indicated in the treatment of: hypertension (when drug combination is required), hypertension with left ventricular hypertrophy (reduced risk of cardiovascular events).
3. How to take Pyzacar HCT
Pyzacar HCT is taken orally, the patient can take it on an empty stomach, with or without food.
Dosage:
Take 1 tablet (50mg/12.5mg)/day, if no response, increase the dose to 2 tablets/1 time/day, maximum 2 tablets/day. Elderly: start 1 tablet (50mg/12.5mg)/day.
4. Side effects of Pyzacar HCT
When using Pyzacar HCT, patients may experience undesirable effects:
Common: Dizziness, dizziness, fatigue Uncommon: hepatitis; diarrhea; a cough. Rare: anaphylactic reactions, angioedema.
5. Contraindications of Pyzacar HCT
Pyzacar HCT is contraindicated in the following cases:
Hypersensitivity to thiazides, sulfonamide derivatives or drug components Gout / increased uric acid, anuria, Addison's disease, hypercalcemia, liver failure, severe renal failure.
6. Precautions when using Pyzacar HCT
Use caution when using Pyzacar HCT in the following cases:
Special supervision or dose reduction in cases of patients with dehydration, when combined with diuretics, the patient has factors that lead to hypothermia. blood pressure, renal artery stenosis, only 1 kidney left. Periodic monitoring of serum electrolytes, urine Use caution in patients with severe renal impairment, liver failure, gout, diabetes The antihypertensive effect of Hydrochlorothiazide is increased after sympathectomy. Increased cholesterol, triglycerides. Elderly patients when taking the drug are prone to electrolyte imbalance Pregnant/lactating women. Driving/operating machines.
7. Drug interactions
Co-administration of Pyzacar HCT with the following drugs may cause drug interactions:
Cimetidine: increased AUC of losartan Alcohol: orthostatic hypotension Colestyramine/colestipol resin reduces absorption of Hydrochlorothiazide, should take Hydrochlorothiazide 1 hour before or after 4 hours Corticosteroids, ACTH: electrolyte loss, especially hypokalemia Cardiac glycosides: hypokalemia / Mg, increased arrhythmias due to digitalis Anti-inflammatory NSAIDs (reduce diuretic effect & lower blood pressure, decrease Nauria); Non-depolarizing skeletal muscle relaxants such as tubocurarin (which increase their effectiveness); Gout medication (Hydrochlorothiazide increases uric acid levels); Calcium salts: increase blood Ca Beta-blockers, diazoxide: increase blood sugar Anticholinergics such as atropine, beperiden: increase thiazide bioavailability Amatandin: increased risk of side effects. The drug Pyzacar HCT has the main ingredients losartan potassium and Hydrochlorothiazide, a drug used in the treatment of hypertension. Patients need to take the drug exactly as directed by the doctor or pharmacist to avoid unwanted consequences.
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