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Pyrantel medicine 125mg contains the main active ingredient, Pyrantel, which has the effect of blocking neuromuscular depolarization and paralyzing helminths. The drug is indicated in the treatment of pinworms, hookworms, roundworms, strongyloides.
1. What is Pyrantel 125mg?
Pyrantel 125mg medicine contains the main active ingredient is Pyrantel with a strength of 125mg. The mechanism of action of the drug is to release acetylcholine and inhibit cholinesterase, block neuromuscular depolarization and paralyze helminths. As a result, the worms will be expelled due to intestinal peristalsis. Pyrantel is highly effective against roundworms (Ascaris lumbricoides), pinworms (Enterobius vermicularis), roundworms (Trichinella spiralis), Trichostrongylus spp and hookworms (Ancylostoma duodenale, Necator americanus). Note Pyrantel has no effect on hairworms (Trichuris trichiura).
Pyrantel is poorly absorbed from the gastrointestinal tract. Peak plasma concentrations are reached 1-3 hours after dosing. Pyrantel is partially metabolised in the liver. Approximately more than 50% of the administered dose is excreted unchanged in the faeces. Less than 7% of a dose is excreted in the urine as unchanged drug and as metabolites.
2. Indications of the drug Pyrantel
Pyrantel drug is indicated in the treatment of infections with pinworms, hookworms, roundworms, strongyloides.
3. Contraindications of the drug Pyrantel
Pyrantel is contraindicated in the following cases:
Hypersensitivity to the components of the drug. Children under 2 years of age because the safety of Pyrantel has not been established in this age group
4. Dosage and usage of Pyrantel
4.1 Adults Infection with roundworms, pinworms, hookworms, Trichostrongylus worms: Take a single dose of 10 mg/kg, up to 1g/time. The anthelmintic effect will be higher if the patient repeats the above dose after 2-4 weeks. Hookworm infection: Take a single dose of 20mg/kg/day (maximum 1g/time), for 2 consecutive days or 10mg/kg/day (maximum 1g/time), for 3 consecutive days. Isolated roundworm infection: Take a single dose of 5 mg/kg (maximum 1 g/time). Toxocariasis: Oral dose of 10 mg/kg/day (maximum 1g/time) for 5 consecutive days. 4.2 Children over 2 years old Infection with roundworm, hookworm: Use dose 10 mg/kg/day for 3 days, maximum 1g/dose. Streptobacillus moniliformis infection: Oral dose of 11mg/kg/time every 2 weeks for 3 doses. Pinworm infection: Should treat the whole family to prevent reinfection Hookworm infection: Take a single dose of 20mg/kg/day, for 2 consecutive days; or 10 mg/kg/day, for 3 consecutive days. Isolated roundworm infection: Take a single dose of 5 mg/kg. Toxocariasis: Oral dose of 10 mg/kg/day for 5 consecutive days. Note, it is best for patients to take Pyrantel between meals, which can be taken with milk or juice. Before and after taking the drug Pyrantel do not need to follow a special diet, do not fast, and do not need additional bleach.
5. Side effects of the drug Pyrantel
When using Pyrantel, patients may experience the following side effects:
Central nervous system: Dizziness, headache, insomnia. Alcohol can increase the side effects of Pyrantel Digestion: Abdominal cramps, nausea, vomiting, diarrhea Other: Rash, increased liver enzymes
6. Notes when using Pyrantel
When using Pyrantel, patients should pay attention to the following issues:
Use Pyrantel with caution in people with impaired liver function. Use caution when administering Pyrantel to malnourished or severely anemic patients. Ideally, patients who are dehydrated, anemic or malnourished should receive supportive treatment prior to administration of pyrantel. The drug can cause some toxicity in children and adults including increased alcohol concentration, lactic acidosis, convulsions and respiratory depression. In case of pinworm infection, all family members should be treated, thoroughly clean the place and clothes to kill all pinworm eggs to prevent reinfection. Remember to wash your hands often, trim nails neatly, wear underwear day and night, mop or vacuum the bedroom floor regularly for a few days after treatment, regularly wash bed linen and clothes after treatment. treatment. Overdose: Symptoms of a Pyrantel overdose include: Difficulty breathing, seizures, muscle spasms, or severe muscle weakness. When an overdose occurs, the patient should immediately go to the nearest medical facility for timely treatment. Pregnancy and breast-feeding: The use of pyrantel in pregnant women has not been well studied. To date, there are no reports of harm to the neonate when the mother takes the drug during pregnancy. However, patients should only take Pyrantel when clearly needed after the first 3 months of pregnancy. Ability to drive and use machines: Because Pyrantel can cause dizziness and drowsiness, patients should be careful when driving, operating machinery and other activities requiring alertness. Drug Interactions: Taking Pyrantel with certain drugs may alter its activity or increase side effects. Note that piperazine and pyrantel have antagonistic effects on worms, so they should not be used in combination. The drug should not be used with some products containing phenylalanine The article has provided information on the uses, dosage and precautions when using Pyrantel. To ensure safety and avoid side effects, patients should consult their doctor or pharmacist before use.
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