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PymeClarocil is an oral antibiotic with the main ingredient clarithromycin, indicated for use in infections caused by bacteria sensitive to this antibiotic.1. Uses of the drug PymeClarocil
PymeClarocil 250 has the active ingredient Clarithromycin 250mg and PymeClarocil 500 has the main ingredient Clarithromycin 500mg. Prepared in film coated tablet form. Clarithromycin is a semi-synthetic macrolide antibiotic, usually bacteriostatic, but at high concentrations or against susceptible bacteria, it has bactericidal action.Mechanism of action of the drug is to bind to the 50S subunit of the ribosome from the longa to inhibit its protein synthesis by bacteria. Antibacterial spectrum on bacteria such as Chlamydia spp., U. urealyticum, M. catarrhalis, M.leprae, Legionella spp., other gram-positive and gram-negative bacteria.
2. Indications and contraindications of PymeClarocil
Indications: PymeClarocil is indicated for use in the following cases:Respiratory tract infections including: Exacerbation of chronic bronchitis, acute bacterial bronchitis, tonsillitis, acute sinusitis, otitis media , community-acquired pneumonia of mild to moderate severity. Inflammation of the skin and soft tissues due to bacterial infection. Patients with advanced peptic ulcer disease caused by H. pylori: Usually used in combination with another antihistamine H2 antagonist or an H+ proton pump inhibitor and another antibiotic to eradicate H. pylori. Superinfection in HIV-infected patients is caused by infection with Mycobacterium avium or M. avium complex. Contraindications: PymeClarocil is not used in the following cases:
Hypersensitivity to macrolide antibiotics or any of the excipients in the formula. Patients with severe liver failure. Patients with hypokalemia cause a prolonged QT interval. Do not use in combination with ergot derivatives or any of the following drugs: Cisaprid, Pimozide and Terfenadin; Astemizol and the drug Simvastatin.
3. Usage and dosage of PymeClarocil
3.1. Using
The drug is taken orally. You can take the drug at any time because its bioavailability is not affected by food. It is recommended to take the drug at a fixed interval, to increase the effectiveness of the drug.3.2. Dosage
Adults and children over 12 years old:Infections of the respiratory tract, skin and soft tissues: The usual dose is 250mg and used twice a day for 7 days. In case of severe respiratory infection, the dose can be increased to 500mg and taken twice a day and the duration of treatment can be extended to 14 days. In peptic ulcers caused by H. pylori infection: You should take 500mg x 2 times/day, a course of treatment usually lasts 7-14 days, depending on the combination treatment regimen. Mycobacterium infections: Initially 500mg twice a day for 3-4 weeks, if not effective can be increased to 1000mg / 2 times / day. Often used for a long time. For patients with renal impairment: When taking this drug, the total therapeutic dose should be halved and the drug should not be used for more than 14 days.
3.3. Overdose
When overdose may experience symptoms: Including symptoms similar to unwanted effects. Patients with bipolar disorder when taking a dose of 8g, they see paranoid behaviors, hypoxia, and mental changes. If the patient accidentally overdoses and has serious side effects, the patient should be taken immediately to a medical center for timely treatment.4. Undesirable effects of the drug PymeClarocil
When taking the drug you may encounter side effects including:Common: Increased BUN, change in tooth color, abnormal taste; Vomiting, abdominal pain and indigestion, headache, nausea, diarrhea; Stomatitis, glossitis, tongue color change; Long-term use often causes overgrowth of non-susceptible microorganisms. Uncommon: Causes prothrombin time prolongation; Decrease in white blood cell count, increase in serum creatinine, increase in transaminase levels; Joint pain, muscle pain, depression; Allergic reactions ranging from mild urticaria, urticaria, and skin rash to severe anaphylaxis have also been reported. Rare: Common liver dysfunction is transient and reversible, cholestatic hepatitis with or without jaundice; Liver and biliary disorders; Very rare: QT interval prolongation, ventricular tachycardia and torsades de pointes; Thrombocytopenia; Pancreatitis; Dizziness, dizziness, paresthesia, convulsions; Interstitial nephritis, renal failure; Tinnitus or reversible hearing loss; Mild to life-threatening pseudomembranous colitis; Fatal liver failure; Stevens-Johnson syndrome, toxic epidermal necrolysis. If you notice any side effects of the drug, you should immediately inform your doctor or qualified pharmacist so that it can be treated promptly.
5. What should be noted when using PymeClarocil?
Antibiotics are used under the prescription of a doctor in case of bacterial infection. You should tell your doctor about any history of allergy to the drug before taking it. Do not increase the dose or change the dose on your own, stop this medicine suddenly as this increases side effects and resistance to this drug. Clarithromycin should be used with caution in patients with impaired renal function. Antibiotics are considered to be responding when symptoms of the disease are relieved 2 to 3 days after taking the drug, the patient needs to continue taking them to avoid re-infection. In case the disease does not decrease or increase, it is necessary to re-examine immediately. In case of prolonged use, it is necessary to prevent non-susceptible infections such as pseudomembranous colitis. If the patient has persistent or severe diarrhea, it should be considered and treated appropriately. Use in Pregnancy and Lactation: There are no adequate and well-controlled studies of this drug in pregnant women and nursing mothers. The drug should only be used if it is absolutely necessary and has weighed the potential benefits and risks. Drivers and Machine Operators: Because when taking this medicine, it may cause dizziness, lightheadedness, affecting the ability to drive or use machines. Use caution in these cases.6. Drug interactions
Several drug interactions have been reported, including: Cisapride, Pimozide and Terfenadine: Concomitant administration may increase serum concentrations of these drugs leading to cardiac arrhythmias, especially torsades de pointes. Therefore, the combination is contraindicated. Erectile dysfunction: Causes acute poisoning manifesting as ischemia of the extremities and central nervous system, causing vasoconstriction. Therefore, the combination is also contraindicated. Drugs metabolized by the enzyme CY3A4: Increased plasma concentrations of clarithromycin. Drugs that induce CYP3A4 (such as Carbamazepine, Efavirenz, Nevirapine, Rifampicin, etc.) reduce plasma concentrations of Clarithromycin. QT interval prolongation, torsades de pointes, cardiac arrest Fluconazole, Ritonavir: Change concentration of clarithromycin, adjust dose if necessary Rifabutin: Increase concentration of rifabutin, but decrease serum concentration of clarithromycin Co-administration increases the risk of uveitis HMG-CoA reductase inhibitors, drugs Sildenafil, Tadalafil, Vardenafil, Tolterodin, Tacrolimus, Cyclosporin, Sirolimus, Warfarin, Theophyllin, Colchicin, Phenytoin and valproate: Increased concentration If these drugs are present in the blood plasma, the dose may need to be adjusted if necessary Anti-diabetic drugs: Increased risk of hypoglycemia. Also, for safety and effectiveness, tell your doctor. doctor about all medications or even health-promoting foods use.7. Storage conditions
The temperature is below 30 degrees Celsius, avoid direct light and keep the medicine out of sight and reach of children. Do not use the medicine after the expiry date printed on the package.PymeClarovil is used under indications and to limit the risk of drug resistance, it should be used exactly as indicated, not for viral infections. During the course of taking the medicine, if the disease does not change or worsens, you should immediately notify the doctor.
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