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Protovan drug belongs to the group of anesthetic drugs, anesthetic is prepared in the form of an infusion suspension. The main ingredient of Protovan is propofol, which is indicated for the induction or maintenance of anesthesia during surgery, or for the maintenance of sedation.
1. Mechanism of action of the drug Protovan
Protovan iInjector is a drug used to induce sleep, intravenous sedation. Because the composition of the drug is slightly soluble in water, the drug is prepared in the form of an opaque white emulsion. The drug administered via intravenous injection has a rapid onset of sleep within 40 seconds starting from the time of injection and a balanced half-life of the drug in the blood and brain.
Protovan is affected by the concentration of the drug in the blood, which is proportional to the rate of infusion. However, these parameters are different in each specific case. When the blood concentration of Protovan is high due to increased injection rate or rapid infusion, cardiac depression and respiratory depression may occur.
The effect of Protovan on induction of anesthesia will vary depending on both ventilation. With spontaneous ventilation, the effect of the drug on the heart is mainly arterial hypotension, with little change in heart rate and output. But with assisted ventilation or positive pressure ventilation, cardiac output will decrease more markedly. Therefore, when combining Protovan with opinoi, there will be a pulse effect to pre-anesthesia, cardiac output and respiratory control force will be further reduced. With continued maintenance of anesthesia with Protovan, with stimulation of intubation and surgery, arterial blood pressure may become normal but cardiac output may still decrease.
When using Protovan to induce anesthesia, there is often a phenomenon of apnea when maintaining anesthesia, thereby affecting hypoventilation and increasing carbon dioxide pressure. However, Protovan did not affect the responsiveness of cerebral vessels to arterial CO pressure. Protovan can also improve nausea and vomiting after surgery.
2. Indications and contraindications to the use of Protovan
Protovan is indicated in the induction or maintenance of anesthesia in the surgical technique of anesthesia for adults or children over 3 years of age. Anesthesia and maintenance of sedation and anesthesia during diagnostic procedures or in combination with local or regional anesthesia during surgery. Protovan also induces and maintains continuous anesthesia to relieve stress in the setting of intubation in adults and should only be performed by an emergency care professional.
However, the drug Protovan may be contraindicated in the following cases:
Patients with hypersensitivity to the ingredients of the drug Do not use in obstetrics, Children under 3 years of age Women who are pregnant or breast-feeding People with severe heart and lung diseases Do not use in electroconvulsive therapy, patients with a history of seizures or convulsions Raised intracranial pressure Cerebral circulatory failure People with hyperlipidemia, hypotension and instability hemodynamic determination.
3.Dosage and usage of Protovan
Dosage for induction of anesthesia with Protovan:
Adults <55 years old: use the drug in 10 seconds, injected once at a dose of 40mg until anesthesia (2-2.5 mg/kg). Elderly patients: Use the drug in 10 seconds inject once with a dose of 20mg until anesthesia (1-1.5 mg/kg). Patients with heart disease: use the drug in 10 seconds inject once with a dose of 20mg until anesthesia (0.5-1.5 mg/kg). Neurosurgery: use the drug in 10 seconds inject once at a dose of 20mg until anesthesia (1-2 mg/kg). Children > 3 years old: apply the drug at a dose of 2.5 to 3.5 mg/kg, intravenously for 20-30 seconds. Maintenance of anesthesia, intravenous infusion:
Adults <55 years old: apply dose of Protovan 100 to 200 micrograms/kg/min. Elderly patients: Apply dose of Protovan 50 to 100 micrograms/kg/min. Neurosurgery: Apply dose of Protovan 100 to 200 micrograms/kg/min. Children > 3 years old: apply dose of Protovan 125 to 300 micrograms/kg/min. Maintenance of sedation - anesthesia with monitor monitoring:
Adults <55 years old: apply dose of Protovan 25 to 75 micrograms/kg/min or intravenously with increasing dose of 10mg or 20mg. Elderly or neurologically ill: Avoid rapid intravenous injection and use Protovan at 80% of the adult dose.
4. Unwanted side effects of the drug Protovan
Protovan can cause some unwanted side effects during treatment. However, with each case Protovan drug can occur in varying degrees from mild to severe.
Some common side effects caused by Protovan include: low blood pressure, bradycardia, fever, headache, respiratory acidosis, abdominal cramps... These side effects can occur at any time. starting treatment or after increasing the dose of Protovan. Usually, side effects from Protovan can be transient or subside over time. However, in some cases, Protovan can cause serious unwanted side effects with rare reactions. These reactions can appear within minutes of using Protovan. When serious side effects such as syncope, extrasystoles, muscle pain, itching, increased salivation appear, the patient should stop using Protovan and should be taken to medical assistance immediately.
Protovan drug belongs to the group of anesthetic drugs, anesthetic is prepared in the form of an infusion suspension. The main ingredient of Protovan is propofol, which is indicated for the induction or maintenance of anesthesia during surgery, or for the maintenance of sedation. To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor and medical staff.
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