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Pramipex is used in the treatment of symptoms of idiopathic Parkinson's disease, moderate to severe idiopathic restless legs syndrome. Pramipex is a prescription drug, patients need to use it according to the instructions and advice from a pharmacist or specialist to use the drug safely and effectively.1. What is Pramipex?
Pramipex belongs to the group of anti-Parkinsonian drugs, made in the form of tablets, boxed specifications of 3 blisters x 10 tablets. The Pramipexol dihydrochloride monohydrate (1g) component in Pramipexol is a non-derived, highly specific in vitro and fully intrinsic dopamine agonist active at the D2 subfamily of the dopamine receptor, with high affinity binding. more with D 3 than with D 2 or D 4 receptor subtypes.
The exact mechanism of action of Pramipexol dihydrochloride monohydrate in the treatment of Parkinson's is unknown, although it is thought to be related to its ability to stimulate dopamine receptors in the striatum. This conclusion is supported by electrophysiological studies in animals that demonstrate that pramipexol dihydrochloride monohydrate affects the rate of neuronal excitability prior to activation of dopamine receptors in the striatum and substantia nigra, the sites of neurons send predictions to the striatum. However, the involvement of the D-binding receptor 3 in Parkinson's disease is unknown.
2. Indications for taking Pramipex
Pramipex is used in the treatment of the following pathological signs/symptoms:
Idiopathic Parkinson's (monotherapy or in combination with Levodopa); Moderate to severe idiopathic restless legs syndrome up to 0.54 mg.
3. Dosage - How to take Pramipex
Treatment dose in adults:
Parkinson's disease: Divide the daily dose of Pramipex into 3 oral doses; Initiation: Pramipex dose 0.264mg/day, if no serious side effects, can be increased gradually every 5-7 days corresponding to 0.54mg - 1.1mg until reaching the maximum therapeutic effect. If further increase is required, increase 0.54 mg every 1 week to a maximum dose of 3.3 mg/day; Maintenance dose: Use Pramipex 0.264mg to a maximum of 3.3mg/day, dose adjustment should be based on response and occurrence of side effects or dose reduction depending on patient response; Stopping therapy: Reduce Pramipex dose at a rate of 0.54 mg/day until the daily dose reaches 0.54 mg, then reduce to 0.264 mg/day. Patients with renal impairment: Adjust the dose of Pramipex according to the concentration of ClCr. Treatment of restless legs syndrome: Start with Pramipex 0.088mg once a day, taking the drug 2-3 hours before bedtime. In cases where further symptom relief is needed, increase the dose every 4-7 days to 0.18mg-0.35mg-to a maximum of 0.54mg/day. Assess response at 3 months and consider continuing with Pramipex. How to take Pramipex:
Pramipe is taken orally with a full glass of water. The medicine can be taken on an empty stomach or on an empty stomach. If the patient forgets a dose of Pramipex, take it as soon as possible. However, if it is almost time for your next dose of Pramipe, skip the missed dose and take the next dose exactly as directed. Note that a double dose of Pramipe should not be taken. In case of an overdose of Pramipex and symptoms occur, immediately call 911 or ask a loved one to take you to the nearest medical facility. Note: The above dose of Pramipex is for reference only. The specific dose of Pramipex depends on the condition and the progression of the disease. To get the right dose of Pramipex, patients should consult their doctor or healthcare professional.
4. Contraindications to taking Pramipex
Do not use Pramipex in case the patient is sensitive to any ingredient of the drug.
Contraindications are understood as absolute. This means that for whatever reason the contraindication is not flexible to taking Pramipex.
5. Interactions with other drugs
Drugs such as Amantadin, Diltiazem, Triamteren, Verapamil, Cimetidin, Cimetidine, Ranitidine, Quinidin, Quinin used at the same time reduce the clearance of Pramipexol. Dopamine antagonists such as metoclopramide or sedatives may decrease the effectiveness of pramipexol. Concomitant use with antipsychotics may have an antagonistic effect. To avoid drug interactions, before being prescribed Pramipex, patients should inform their doctors about all the drugs they are using, including functional foods. The doctor will base on that to prescribe the appropriate Pramipex.
6. Side effects of the drug Pramipex
In addition to its therapeutic uses, Pramipex can cause some of the following side effects for patients:
Dizziness; Movement disorders ; Sleepy; Nausea. Abnormal dreams; Impulse control disorder and compulsive impulses; Confusion; Illusion; Insomnia; Headache; Visual impairment ; Double vision; Blurred vision; Lower blood pressure; Constipation, vomiting; Fatigue, peripheral edema; Weight loss; Decreased appetite.
7. Be careful when using Pramipex
Caution when using Pramipex for the following subjects:
Patients with severe cardiovascular disease; People with mental disorders should only be treated with Pramipex if the benefits outweigh the risks; Parkinson's disease: If movement disorders occur when starting to adjust the dose of Pramipex, the dose should be reduced. In the event of progressive mania and delirium, somnolence and/or somnolence, and development of impulse control disturbances, the dose of Pramipex should be gradually reduced/discontinued. Pregnant women should take Pramipex only if the benefits outweigh the risks; Breastfeeding women should not take Pramipex. If the drug must be taken, breast-feeding should be discontinued. Have your eyes checked if there are vision abnormalities. When using Pramipex with sedatives, alcohol / alcohol needs to be cautious. Neuroleptic malignant syndrome. Drivers and machine operators need to be careful because the drug can cause side effects such as headache and dizziness. Above is all information about Pramipex, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, Pramipex is a prescription drug, patients need to use the drug as prescribed by the doctor, absolutely do not self-treat at home.
