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Pinadine Inj drug has the main ingredient Neostigmine methylsulfate 0.5mg/ml. Knowing the necessary information of Pinadine Inj drug about ingredients, uses, doses and side effects will help improve treatment results for patients.
1. Uses and indications of Pinadine Inj
Pinadine Inj drug belongs to the group of muscle relaxants and increases muscle tone. The drug is in the form of a solution for injection, packed in a box of 10 ampoules of 1ml. Currently, Pinadine Inj is indicated for the treatment of:
Loss of bowel and bladder tone. Myasthenia gravis. Detoxification of an overdose of cura-type muscle relaxants.
2. Contraindications of Pinadine Inj
Pinadine Inj is contraindicated in the following cases:
People with intestinal obstruction and urinary tract obstruction due to mechanical causes or peritonitis. There is a history of hypersensitivity to Neostigmine and Bromide (bromide ion from neostigmine can cause allergic reactions).
3. Dosage and how to use Pinadine Inj
Dosage:
Intestinal or bladder atony: Prophylactic treatment as soon as possible after surgery. Subcutaneous injection of 0.25 mg (0.1 ml) every 4-6 hours, for 2-3 days. Treatment of paralytic ileus after surgery: 0.5 - 1.0 mg subcutaneous injection (0.2 - 0.4 ml). Pinadine Inj is effective for 10-30 minutes after injection. Myasthenia gravis: The individual dose depends on the severity of the disease and individual response. Oral treatment is recommended when possible. Adult dose: 15mg at first, every 3-4 hours. Dosage and interval of oral administration are adjusted if necessary. The average maintenance dose is 150 mg (range 15 - 375 mg) per day. For people with severe myasthenia gravis, 0.5 mg should be injected intramuscularly or subcutaneously. Subsequent doses should be based on individual response. For children's dose: Take 2mg for 1 kg of body weight, divided into 6-8 doses per day. In case of intramuscular or subcutaneous injection: 0.01 - 0.04 mg per 1 kg body weight, every 2-3 hours. Detoxification of cura overdose: Initiate treatment with intravenous atropine sulfate (at least 1 mg). The pulse rate should be increased and then neostigmine should be administered intravenously at a dose of 0.5 - 5 mg. It needs to be injected slowly, gradually, and carefully adjusted for Pinadine Inj to be effective. Note: The above Pinadine Inj dosage is for reference only. The specific dose of Pinadine Inj depends on the condition and the progression of the disease. To get the right dose of Pinadine Inj, patients should consult their doctor or healthcare professional.
How to handle a missed dose or overdose of Pinadine Inj:
In case of forgetting a dose of Pinadine Inj, it should be supplemented as soon as possible. However, if it is almost time for the next dose, skip the missed dose of Pinadine Inj and use a new dose. When using Pinadine Inj drug overdose, the patient should stop the drug immediately and go to the nearest medical facility for timely treatment.
4. Pinadine Inj . drug interactions
Neostigmin may interact with hydrocarbon inhalation anesthetics such as: Cyclopropan, Chloroform, Enfluran, Halothan, Methoxyfluran and Trichloroethylene. The inhibition of plasma cholinesterase activity of myasthenia gravis reduces the metabolism of these anesthetics, leading to an increased risk of toxicity. High doses of Pinadine Inj may reduce quinine's neuromuscular blocking activity. In renal failure, Pinadine Inj prolongs (1 - 2 hours) the effect of Suxamethonium (this drug was given several hours after kidney transplant). Atropin antagonizes the muscarinic effects of Pinadine Inj and this interaction is used to relieve muscarinic symptoms in Neostigmine poisoning. To avoid interactions, before being prescribed Pinadine Inj, the patient should inform the doctor about the drugs they are using, including functional foods. The doctor will base on that to prescribe the appropriate Pinadine Inj.
5. Side effects of the drug Pinadine Inj
For Pinadine Inj, there is not enough reliable information to make an accurate estimate of the degree of risk for various adverse reactions. In general, however, adverse reactions to Pinadine Inj will be directly related to symptoms that have occurred frequently.
Pinadine Inj may cause common side effects such as: pupillary constriction, sweating, bradycardia, hypotension, increased salivation and increased lacrimation. Serious side effects of Pinadine Inj include: bronchospasm, asthma and bradycardia. Rare side effects of Pinadine Inj include: Atrioventricular block, muscle spasticity, diarrhea, and injection site reactions. If you experience these symptoms, the patient should stop using Pinadine Inj and notify the doctor for appropriate treatment.
6. Precautions when using Pinadine Inj
Caution when using Pinadine Inj for asthmatics, due to the risk of causing bronchospasm and asthma. When using Pinadine Inj to detoxify cura, it must be done by an experienced anesthesiologist. Extreme caution should be exercised when Pinadine Inj is administered to patients with recent bowel or bladder surgery or in patients with cardiovascular disease including arrhythmias, bradycardia and hypotension, as well as in patients with increased parasympathetic nervous system tone. , epilepsy, hyperthyroidism, Parkinson's, bronchial asthma or peptic ulcers (thus increasing the risk of arrhythmias). Do not use Pinadine Inj for patients under anesthesia with cyclopropan, halothan. Caution should be exercised in patients receiving systemic Pinadine Inj for myasthenia gravis or concurrently receiving ophthalmic anti-acetylcholinesterase agents such as ecothiopat, as toxicity may be further increased. Because Pinadine Inj is metabolised in the liver and eliminated by the kidneys. Caution should be exercised when using Pinadine Inj in patients with liver or kidney disease. Pinadine Inj should not be used by pregnant women. Pinadine Inj is a class A poison. It should be stored in an airtight container at a temperature below 40 degrees Celsius, preferably between 15 and 30 degrees Celsius. Protect from cold and light. Keep Pinadine Inj out of the reach of children. The article has provided information on dosage, contraindications and notes during use and Pinadine Inj therapeutic uses. To ensure that Pinadine Inj is working optimally and to prevent side effects, patients should consult their doctor/pharmacist before use.
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