This is an automatically translated article.
With cardiovascular diseases, on the market there are many drugs used in the treatment such as Pamlonor 5mg, Amlodipine 5mg SANOFI, Normodipine 5mg, Tenox 5mg. However, each patient is different and each drug is appropriate. To better understand the use of the drug Pamlonor is what? What are the side effects of Pamlonor? What is the correct way to drink? What points should be kept in mind when using? The following article will help you better understand Pamlonor.
1. What is Pamlonor?
Pamlonor is manufactured by Pharmaceutical Works Polfa Company - Poland and has the main ingredient Amlodipine. Pamlonor is also indicated for the treatment of hypertension, used alone or in combination with other antihypertensive drugs, treatment of myocardial ischemia and prevention of the risk of angina in patients with angina. stable, angina with vasoconstrictor factor.
Pamlonor is in the form of tablets. The box will include 3 blisters x 10 tablets.
1.1. Pharmacodynamics Amlodipine is a calcium antagonist of the dihydropyridine class. This drug inhibits the transmembrane influx of calcium into cardiac and smooth muscle cells of the vascular wall by blocking the slow calcium channels of the cell membranes. Thanks to the effect of the drug, the smooth muscle tone of the blood vessels decreases and thereby reduces the peripheral resistance, leading to a decrease in blood pressure.
Amlodipine fights angina mainly by dilating the peripheral arterioles and reducing cardiac afterload. The myocardial energy consumption and oxygen demand are reduced because the drug does not cause reflex tachycardia. Amlodipine also dilates coronary vessels (arteries and arterioles) in both normal and ischemic regions leading to increased myocardial oxygen delivery.
1.2. Pharmacokinetics Absorption
The bioavailability of amlodipine after oral administration is approximately 60-80% and is unaffected by food. The half-life is 30 to 40 hours. Stable plasma concentrations are achieved 7-8 days after once-daily dosing.
Distribution
The volume of distribution is approximately 21l/kg body weight and the drug is also highly protein-plasma bound (over 98%).
Metabolism and Elimination
The drug is metabolized mainly by the liver. The metabolites are inactive and excreted in the urine. For patients with liver failure, it is necessary to reduce the dose or prolong the time between doses.
2. What are the uses of Pamlonor?
This is a substance capable of antagonizing calcium ions and hindering the flow of calcium ions into cardiac and smooth muscle cells. It relaxes the heart and smooth muscles, lowering blood pressure and reducing angina. The antihypertensive effect of this active ingredient is due to the relaxation of vascular smooth muscle, thereby reducing afterload. Besides, the effect of helping to relieve angina may be due to: + Lowering the energy consumption of the myocardium and reducing the need for oxygen supply, thereby reducing the workload of the heart. + At the same time, the dilation of the coronary arteries and main coronary arterioles will also increase the amount of oxygen to the heart muscle.
Pamlonor 5mg is used in the following cases: - Treatment of hypertension, used alone or in combination with other antihypertensive drugs.
Treatment of myocardial ischemia. Prevention of the risk of angina in patients with stable angina. Angina also has a vasoconstrictor factor.
3. Side effects of the drug Pamlonor
Amlodipine is generally well tolerated. In controlled clinical studies enrolling patients with hypertension or angina, the most common adverse events were headache, edema, or fatigue, somnolence, nausea, abdominal pain, and flushing. red, nervous and dizzy. There were also no clinically significant changes in routine laboratory tests due to drug administration in these clinical studies. During the widespread use of amlodipine, in addition to the above-mentioned side effects, there were also changes in gastrointestinal activity, joint pain, weakness, shortness of breath, dyspepsia, gingival hyperplasia, gynecomastia, and frequent urination. times, mood swings, myalgia, pruritus, rash, visual disturbances, rare erythema multiforme. Jaundice is very rare and is mainly related to cholestasis – or elevated liver enzymes. In some cases hospitalization is required, but causality is also uncertain. As with other calcium channel blockers, the following adverse events are rare and indistinguishable from the underlying disease: myocardial infarction, arrhythmias (including ventricular tachycardia and atrial fibrillation). ), chest pain. Side effects may not be the same depending on the body of each person. Inform your doctor immediately of any unwanted effects you experience while taking the drug.
4. Drug interactions:
Anesthetic drugs will increase the antihypertensive effect of amlodipine and may cause a more drastic decrease in blood pressure.
Lithium: When used together with amlodipine, can cause neurotoxicity, nausea, vomiting, diarrhea.
Nonsteroidal anti-inflammatory drugs, especially indomethacin, may reduce the antihypertensive effect of amlodipine by inhibiting prostaglandin synthesis and/or sodium and fluid retention.
Drugs that are highly protein bound (such as coumarin derivatives, hydantoin...) must be used with caution with amlodipine, because amlodipine is also highly protein bound, so the concentrations of these drugs are in the free form (unbound). ) may vary in serum.
5. How to use Pamlonor effectively
5.1. How to use Taking the drug by mouth, avoiding breaking or chewing the tablets can reduce the effectiveness of the drug. When using, drink a lot of water. Patients should not stop taking the drug or change the dose on their own without consulting a doctor. For people with high blood pressure, it is necessary to adjust the scientific diet along with the lifestyle combined with the use of drugs. Knowledge of the management of sudden high blood pressure is required. 5.2. Dosage Dosage may vary according to individual patient response. Recommended dose:
High blood pressure: + The starting dose is 5mg/time/day, the maximum can be used 10mg/time/day.
+ When the health condition is poor, people with impaired liver function or are taking with other antihypertensive drugs, start with 2.5mg / day.
Angina: 5-10 mg/day, 10mg/day in severe cases. 5.3. How to deal with missed dose, overdose Missed dose: It is best to use the right medicine and at the right dose to bring about effective treatment. When you forget to take a medicine, you must take it as soon as you remember it as soon as possible. Do not take a double dose to make up for the dose.
Overdose :
+ Symptoms: Excessive peripheral vasodilation, systemic hypotension.
+ Management: Cardiovascular support measures such as regular check of heart and respiratory function, monitoring of circulating fluid volume, urine. In case of an emergency, go to the nearest medical facility or contact a doctor for timely intervention.
6. Note when using medicine and how to store it
6.1. Use in pregnant women and nursing mothers Pregnant women : May inhibit uterine contractions. However, the adverse effects of the drug on childbirth have not been proven. Therefore, it is necessary to consult a doctor before choosing.
Lactation: Safety in nursing women has not been established. Use only when the benefits outweigh the risks. It is best to consult a doctor.
6.2. People who drive and operate machinery The drug may cause dizziness, headache, impaired vision, affect the ability to drive and use machines. Care must be taken when using Pamlonor 5mg for this group of subjects.
6.3. Special precautions Patients with impaired liver function, aortic stenosis and heart failure after acute myocardial infarction should be used with caution. Must follow the doctor's instructions. At the same time, must follow a reasonable and scientific diet, living, and rest. 6.4. Storage conditions Keep the medicine in a cool, dry place. The temperature is below 30 degrees Celsius. Check the expiry date carefully before using. Discard if the drug shows signs of spoilage, mold, or discoloration. Avoid exposure to direct sunlight. Keep out of reach of CHILDREN.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
