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Palibone 70mg medicine is commonly used to prevent and treat osteoporosis in postmenopausal women or the elderly. To achieve optimal results when using Palibone, patients need to carefully consult the doctor's advice and follow the instructions exactly.
1. What is Palibone 70mg?
Palibone 70mg belongs to the group of musculoskeletal drugs, manufactured by Atlantic Pharma- Producoes Farmaceuticas S.A – Portugal. The drug is used in osteoporosis conditions in the elderly / menopausal women. Palibone is prepared in the form of film-coated tablets, with packaging specifications of 1 blister x 4 tablets.
Each Palibone 70mg tablet contains the following active ingredients:
Main active ingredient: Sodium alendronate trihydrate 70mg (Alendronic acid). Excipients are sufficient: Croscarmellose sodium, Microcrystalline cellulose, Sodium stearyl fumarate, Colloidal anhydrous silica and Opadry 20A28569.
2. Indications and uses of Palibone 70mg
2.1. Indications for use of the drug Palibone 70mg Palibone medicine 70mg is usually prescribed by doctors for the following cases:
Treatment and prevention of osteoporosis in men, postmenopausal women and the elderly. Treatment of osteoporosis caused by glucocorticoids. Treatment of osteoporosis caused by Paget's disease of bone. Treatment of osteoporosis in postmenopausal women at risk for vitamin D deficiency. Used to reduce the risk of hip and vertebral fractures. Inhibits bone resorption and prevents osteoporosis. 2.2. Uses of the drug Palibone 70mg *Pharmacodynamics:
Active ingredient Alendronate acid is a Bisphosphonate, capable of inhibiting specific bone resorption. Some preclinical studies have shown that the main active ingredient in Palibone has a tendency to selectively accumulate at sites of bone resorption where alendronate acid inhibits the activity of osteoclasts, thereby reducing the rate of bone resorption. risk of fractures, making bones stronger.
*Pharmacokinetics:
When a dose in the range of 5 - 70 mg Alnedronate was taken in women, average bioavailability of the drug was 0.64% (taken after one night of fasting and about 2 hours before meals. main meal). After intravenous administration of Alendronate at a dose of 1mg/kg, the active substance is transiently distributed in soft tissues, then redistributed in bone or excreted in the urine.
It is estimated that about 78% of Alendronate is bound to proteins in human plasma and there is no evidence of evidence of its metabolism in vivo. Following a single IV injection of 10mg Alendronate, renal clearance reached 71 ml/min. Within 6 hours of intravenous administration, plasma concentrations of Aendronate decreased by > 95%. It is estimated that the terminal half-life of Alendronate exceeds 10 years, which reflects the release of the active substance from the skeleton.
3. Dosage and how to use Palibone 70mg
3.1. Dosage of Palibone 70mg The dose of Palibone medicine according to the general recommendation of the doctor is 70mg / time / week (equivalent to 1 tablet). The duration of drug use will be determined through an individual assessment of the benefits and risks of the drug, especially after 5 years of use. For patients with hepatic impairment, mild/moderate renal impairment (creatinine clearance 35 - 60ml/min) and elderly people do not need to adjust the dose.
3.2. How to use Palibone 70mg As recommended by experts, patients should take Palibone with a large glass of water at least 30 minutes before eating. The best time to get the medicine into the stomach easier is when you first wake up during the day.
When taking, the patient needs to swallow the tablet whole, avoid chewing or let the drug dissolve in the mouth, because this can cause mouth ulcers. In addition, you should also avoid lying down immediately after taking (at least 30 minutes). Do not take Palibone before going to bed or while lying in bed when you first wake up.
Palibone should only be taken with filtered water, avoid taking with carbonated drinks, soft drinks or food because they can reduce the absorption of Alendronate active ingredient. In addition, patients should also supplement with vitamin D and calcium if the diet does not provide enough of these substances.
3.3. What to do when taking an overdose or forgetting a dose of Palibone 70mg In case of forgetting a dose of Palibone 70mg:
When you miss a dose of Palibone, the patient needs to take 1 pill early in the morning as soon as he remembers. Absolutely do not take a double dose (2 tablets / day), instead continue to take the next dose on the same day as prescribed by the doctor. In case of Palibone 70mg overdose:
When taking more than 70mg Palibone / time / week, patients may experience some side effects of overdose, such as digestive disorders, decreased calcium / blood phosphate, inflammation stomach ulcers, esophagitis, and heartburn. When there are signs of suspected overdose after taking Palibone, the patient should notify the doctor as soon as possible for timely treatment. To resolve the Palibone overdose, the patient can be given milk or an antacid, while keeping the body in a fully upright position. Avoid inducing vomiting in patients with an overdose of Palibone, as this may potentially irritate the esophagus, making the ulceration worse.
4. Some side effects of Palibone 70mg
Palibone medicine very rarely causes side effects, but there are still some cases that occur after taking the drug. In general, the side effects of Palibone are mild, so patients do not need to stop taking the drug completely. Here are some side effects caused by Palibone 70mg medicine, including:
Pain or headache. Distention . Bloating. Difficulty swallowing. Esophageal ulcers. Stomach acid reflux. Hives or signs of a red rash on the skin. Gastritis. Angioedema (rare). Nausea, vomiting. Esophageal perforation. Sore throat. Sensitive to light. Uveitis. Eye inflammation. Hair loss. When patients notice any of the symptoms mentioned above during treatment with Palibone, patients should temporarily stop taking the drug and talk to their doctor to get the right treatment.
5. Some things to keep in mind during the treatment with Palibone 70mg
5.1. Cases of contraindications to the use of Palibone Palibone should be avoided in the following cases:
People with hypersensitivity or sensitivity to the active ingredient Alendronate or any other ingredient in the drug. People with esophageal abnormalities that slow down the expansion of the esophagus, such as spasm or narrowing of the esophageal sphincter. Inability to sit or stand upright for 30 minutes. People with hypocalcemia. 5.2. What precautions should be taken when using Palibone 70mg Before and during the treatment of osteoporosis with Palibone, patients need to strictly follow the instructions of a specialist doctor, avoid self-medicating with the drug at will. core. Besides, patients also need to be careful with some of the following things when using Palibone:
Active ingredient Alendronate in the drug has the ability to inhibit the upper part of the gastrointestinal tract, so people with gastrointestinal diseases (such as duodenitis, gastritis, esophagitis or dysphagia) extreme caution should be exercised when administering the drug. Patients with a history of gastrointestinal disease, such as gastrointestinal bleeding, peptic ulceration, or undergoing gastrointestinal tract surgery, should exercise caution when treating osteoporosis with Palibone. Patients with Barnet's esophagus should talk to their doctor about the benefits and risks before deciding to take Palibone. When using Palibone, patients may experience esophageal reactions, such as esophageal ulceration due to esophageal stricture or esophagitis. The risk of a serious esophageal reaction is increased if the patient is using Palibone the wrong way, or continues to use it even if symptoms of esophageal irritation develop. Before using Palibone, it is important to evaluate other causes of osteoporosis besides aging and estrogen deficiency. Hypocalcemia should be corrected before the patient begins treatment for osteoporosis with Palibone. In addition, other disorders of mineral metabolism such as vitamin D deficiency should also be treated before using Palibone. Because Palibone can reduce blood calcium levels, patients should supplement calcium sources through their daily diet, and monitor blood calcium levels through regular blood tests. When using Palibone, patients also need to prioritize regular dental care and checkups to promptly notify the doctor if abnormal signs appear. Never use Palibone after the expiry date printed on the package, or any change in the texture and color of the pill. 5.3. Note the use of Palibone 70mg for special subjects *Use of Palibone for pregnant women and nursing mothers
Some animal tests have shown that the active ingredient Alendronate in Palibone can cause birth difficulties, incomplete bone formation and negatively affect the fetus as well as the newborn. Therefore, Palibone 70mg is not recommended for use in pregnant women.
Currently, there is not any accurate information about Palibone drug excreted in breast milk, so women who are breastfeeding should consult a doctor before taking and use the drug only when absolutely necessary. .
*Use Palibone for machine and vehicle operators
Because the drug can cause headache side effects, so patients with specific work needs to be highly concentrated, for example: Driving or operating machinery requires extreme caution when using Palibone to prevent unfortunate incidents.
5.4. Interactions of Palibone 70mg with other drugs When combining Palibone with the following drugs or substances, it may lead to interactions that affect the effectiveness of the drug, including:
Drinks and foods: Reduces absorption collect Palibone. Aspirin : Leads to gastrointestinal side effects. NSAIDs: Irritating to the gastrointestinal tract. To ensure safety and minimize interactions between drugs, patients need to inform their doctors about all drugs, vitamins and supplements they are using to have an appropriate adjustment strategy.
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