Uses of Osarstad 80

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1. What are the effects of Osarstad 80?

Osarstad 80 belongs to the group of angiotensin II receptor antagonists, the main ingredient is Valsartan 80mg. Osarstad 80mg drug is made in the form of film-coated tablets, indicated for the treatment of the following cases:
Hypertension in children over 6 years old, primary hypertension in adults. 12 hours to 10 days after myocardial infarction in clinically stable adults, asymptomatic left ventricular systolic dysfunction or symptomatic heart failure. Adults with symptomatic heart failure who cannot take angiotensin-converting enzyme (ACE) inhibitors or beta-blockers should receive therapy in addition to an ACE inhibitor.

2. Dosage and how to use Osarstad 80

Osarstad 80 is taken orally, should be taken with water and can be taken with or without meals.
2.1. Dosage of Osarstad drug 80mg in adults Treatment of hypertension: The initial dose of 80mg / time / day (equivalent to 1 tablet / time / day), has a significant and maximum antihypertensive effect in 2-4 weeks. The dose may be increased to 160 mg/time/day (equivalent to 2 tablets/day) and to a maximum of 320 mg/time/day (equivalent to 4 tablets/day) in hypertensive patients unresponsive to 80mg dose. Treatment after myocardial infarction: If the patient with myocardial infarction is clinically stable, treatment with Osarstad 80 can be started as early as 12 hours. The initial dose is 20mg/time, 2 times/day and in the following weeks the dose can be adjusted to 40mg, 80mg and 160mg/time and twice/day, up to a maximum of 160mg/time and 2 times/day. Depending on the tolerability of the patient, usually after 2 weeks, the patient will reach the dose of 80mg/time, 2 times/day and after 3 months reach the dose of 160mg/time, 2 times/day. Dosage reduction should be considered in the presence of renal dysfunction or symptomatic hypotension. Osarstad 80 can be combined with other myocardial infarction therapies, but the combination with ACE inhibitors is not recommended. Treatment of heart failure: Initial dose 40mg/time, 2 times/day. In case patients tolerate Osarstad 80 well, it can be increased to 80-160 mg/time, 2 times/day, the highest dose should be adjusted for at least 2 weeks. If the patient is taking diuretics, a dose reduction should be considered. Osarstad 80mg can be combined with other heart failure therapies, but not the 3 drug classes: Osarstad 80, beta-blockers and ACE inhibitors. Elderly: No dose adjustment is required in elderly patients. 2.2. Dosage of Osarstad 80 in children Treatment of hypertension: The dose is based on the child's weight, the initial dose is 40mg/time/day (children <35 kg), 80mg/time/day (children >35kg). Depending on the ability to respond to the drug, adjust the appropriate dose, the maximum dose also depends on the weight of the child 80mg (children from 18-35kg), 160mg (children from 35-80kg), 320mg (children from 80-160kg). ). Treatment of heart failure and after myocardial infarction: Osarstad 80 should not be used in children under 18 years of age with heart failure and myocardial infarction. 2.3. Dosage of Osarstad 80 in adults and children with renal and hepatic impairment
Adults: Patients with CICr ≥ 10 mL/min do not need dose adjustment but caution if ClCr < 10 mL/min. Children: Children with ClCr < 30 mL/min should not take Osarstad 80. Children with ClCr > 30 mL/min do not require dose adjustment. During administration, it is necessary to closely monitor serum potassium and renal function. Hepatic impairment: The dose should not exceed 80 mg in patients with mild and moderate hepatic impairment and without cholestasis. Osarstad 80 should not be used in people with severe liver failure, cholestasis, and biliary cirrhosis. Depending on the condition and the progress of the disease, the doctor will prescribe the appropriate dose.

3. Osarstad 80 . side effects

Osarstad 80 can cause some side effects with the following frequencies:
Common: Dizziness, especially when changing positions, hypotension or orthostatic hypotension. Uncommon: Cough, abdominal pain, increased blood potassium concentration, syncope, headache, heart failure, angioedema, acute renal failure, increased serum creatinine, fatigue, asthenia. Frequency not determined: Thrombocytopenia, neutropenia, hemoglobin, hematocrit, decreased blood sodium concentration, increased liver function indices, vasculitis, pruritus, rash, myalgia, impaired renal function . After taking Osarstad 80mg, if you see any of the above side effects, you should stop taking the drug immediately and notify your doctor or go to a medical facility.

4. Some notes when using Osarstad 80

Do not use Osarstad 80 for people with hypersensitivity to the components of the drug, people with severe liver failure, cholestasis, biliary cirrhosis, pregnant women in the second and third trimesters of pregnancy. . Monitor potassium levels in the blood when taking drugs, especially do not supplement with potassium or drugs and preparations that keep potassium. In rare cases, treatment with Osarstad 80 mg may cause symptomatic hypotension in people with severe fluid loss and sodium deficiency due to high doses of diuretics. At that time, it is necessary to treat rehydration or sodium replacement by reducing the dose of diuretics for the patient. Renal function should be monitored when Osarstad 80 is initiated in patients with unilateral or bilateral renal artery stenosis because the drug may increase blood urea and serum creatinine levels. Osarstad 80 should not be used in patients with primary hyperaldosteronism because the drug is not activated. Osarstad 80 should be used with caution in patients with mitral stenosis, aortic stenosis, and obstructive myocardial hypertrophy. For the management of post-heart failure and myocardial infarction, caution should be exercised and evaluation should include assessment of renal function. People with a history of angioedema with manifestations such as swelling of the face, lips, tongue, throat, swelling of the larynx, glottis obstructing the airway may also experience this side effect when taking Osarstad. At that time, the drug should be stopped and should not be used again after treatment. People with galactose intolerance, glucose-galactose malabsorption or total lactase deficiency should not take Osarstad 80 because it contains lactose. The use of Osarstad 80 is the treatment of hypertension in children and primary hypertension in adults, treatment after myocardial infarction, heart failure when clinically stable, and treatment of heart failure when patients are clinically stable. patients cannot take beta-blockers or ACE inhibitors.

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