This is an automatically translated article.
Orafix is a drug belonging to the group of non-steroidal anti-inflammatory drugs, analgesics, antipyretics. Orafix 35 is indicated for the treatment and prevention of osteoporosis in postmenopausal women, prevention of fractures in postmenopausal women with osteoporosis, treatment of osteomyelitis deformity, ....
1. Uses of Orafix 35
The main ingredient in Orafix 35 is risedronate sodium. This is a member of a group of non-steroidal drugs known as bisphosphonates that inhibit the process of bone resorption, the active ingredient risedronate acts directly on bones, thereby making bones less likely to break. Therefore, Orafix 35 is specifically indicated in the following cases:
For the treatment and prevention of osteoporosis in postmenopausal women, prevention of fractures in postmenopausal women with osteoporosis. Treatment of osteomyelitis deformity. Treatment of osteoporosis in men. In addition, Orafix 35 is also indicated in some other cases when prescribed by a doctor.
2. Contraindications of Orafix 35
Patients with a history of allergy, hypersensitivity to risedronate sodium or any ingredient of Orafix 35. Patients with hypocalcemia or a decrease in blood calcium levels. Patients with severe renal impairment (patients with creatinine clearance less than 30ml/min). Pregnant women, lactating women, children and adolescents. Patients with esophageal abnormalities such as esophageal stricture or inability to dilate. Patient is unable to stand or sit for at least 30 minutes.
3. Dosage and how to use Orafix 35
3.1. Dosage Dosage of Orafix 35 to prevent and treat osteoporosis: take 1 Orafix 35 tablet per week (to be taken on certain days of the week). Dosage of Orafix 35 to treat osteomyelitis deformity: take 1 tablet x 1 time/day, use the drug continuously for 2 months. 3.2. The best time to take Orafix 35 is on an empty stomach, at least 30 minutes before breakfast or at least 2 hours from other meals or at least 30 minutes before bedtime. Take Orafix 35 with filtered or boiled water, take it immediately after taking it out of the blister, swallow the tablet whole, do not break, suck or chew it, keep an upright position for at least 30 minutes after taking it to make it easier for the medicine to reach the stomach.
Avoid taking Orafix 35 with vitamin D and calcium. It is important to include products containing calcium and vitamin D in the diet, such as eggs, milk and dairy products, and calcium and vitamin D supplements if dietary intake is inadequate.
If you forget to take a dose of Orafix 35, take it as soon as you remember it the next day. Absolutely do not take 2 Orafix 35 pills in the same day.
When overdose of Orafix 35 can lead to decrease in serum calcium and phosphorus in some patients, in addition, some patients also have signs and symptoms of hypocalcemia such as: muscle stiffness, muscle spasms. muscle cramps, convulsions, low blood pressure, stinging sensation in fingers or toes, ...
How to handle an overdose of Orafix 35: Patients should drink milk or antacids containing magnesium, calcium or aluminum to reduce the absorption of Orafix 35 . In case of severe overdose of Orafix 35, the patient should be taken to the nearest medical facility for gastric lavage to remove unabsorbed drug or intravenous calcium injection to restore ionized calcium. , reduce the symptoms of hypocalcemia.
4. Orafix 35 . side effects
Orafix 35 can cause many unwanted effects for users. The following are the side effects of Orafix 35: vomiting, nausea, indigestion, difficulty swallowing, itching, hives, abdominal pain, constipation or diarrhea, headache, peptic ulcer disease, reflux. reverse, belching, muscle, bone, joint pain, muscle cramps, muscle aches, hypocalcemia, hypophosphataemia, ...
5. Drug interactions
Some drugs and foods can interact when used together with Orafix 35. Orafix 35 can interact with the following drugs, including:
When using Orafix 35 at the same time with drugs containing cations Multivalent drugs such as calcium, magnesium, iron, aluminum can interfere with the absorption of Orafix 35. Drugs containing polyvalent cations should be taken at a different time of day, away from the time of taking Orafix 35. Orafix 35 can be used concurrently with estrogen supplements if carefully considered and prescribed by a doctor. The active ingredient risedronate contained in Orafix 35 is not metabolized in the body, does not induce P450 enzymes and is less protein bound.
6. Be careful when taking medicine
Caution should be used when using Orafix 35 to treat patients with a history of esophageal disorders such as esophageal stricture, esophageal spasm, slowing down swallowing and passing food through the esophagus. Orafix 35 should be used with caution in patients with acute upper gastrointestinal disorders or in patients with upper gastrointestinal tract problems including Barrett's esophagus. Hypocalcemia and problems of bone and mineral metabolism such as parathyroid dysfunction, vitamin D deficiency should be thoroughly treated before taking Orafix 35 for treatment. Calcium and vitamin D supplementation is important for all patients especially those with Paget's disease who have significantly increased bone turnover. Sex steroid hormone status in both men and women should be determined prior to initiating Orafix 35 for the treatment and prevention of glucocorticoid-induced osteoporosis, considering appropriate alternatives. While taking Orafix 35 to treat patients, it is necessary to avoid invasive dental procedures such as tooth extraction, dental implants. For patients with osteonecrosis of the jaw during treatment with Orafix 35, dental surgery may aggravate the osteonecrosis of the jaw. In patients receiving Orafix 35 for the long-term treatment of osteoporosis, atypical femoral fractures have been reported. Therefore, while taking Orafix 35 patients should be advised to report any thigh pain, hip pain or groin pain to evaluate for a femoral fracture. Discontinue Orafix 35 in patients suspected of having an atypical femoral fracture. Store Orafix 35 at room temperature, in a cool, dry place, away from light and reach of children.
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