Uses of Nykob 5mg

This is an automatically translated article.

1. What is Nykob 5mg? What's the use?

Nykob medicine 5mg is a product manufactured in Greece by Genepharm S.A. The main ingredient of the drug is Olanzapine which is known for its antipsychotic properties with pharmacological activities on multiple receptor systems.
In previously published preclinical studies, Olanzapine had high affinity for serotonin 5HT 2A/2C, Dopamine D 1-4, Muscarinic M1-5, adrenergic alpha 1 and histamine H1 receptors. In particular, this component is weakly bound to GABA, BZD and beta adrenergic.
The mechanism of action of Olanzapine and other drugs used to treat schizophrenia is poorly documented. However, it is believed to have the potential to treat schizophrenia through a combination of dopamine and serotonin 5HT2 agonists.

2. Indications and contraindications Nykob 5mg

2.1. Indications Nykob 5mg is commonly used in the treatment of patients with schizophrenia. Used for long-term treatment of first responders. Used in cases of moderate to severe mania. Effective prevention of relapse of bipolar disorder in drug responders. 2.2. Contraindications Do not use Nykob 5mg in the following cases:
Patients with hypersensitivity to any component of the drug Nykob 5mg. People at risk for closed-angle glaucoma. Children, pregnant women at any stage. People with mental diseases related to memory loss, loss of behavioral control should not use the drug due to an increased likelihood of death, cerebrovascular accident. Because Nykob 5mg antagonizes Dopamine, when used can aggravate Parkinson's disease. Therefore, absolutely do not use this medicine for people with this disease.

3. Dosage and how to take Nykob 5mg

3.1. Dosage To use the drug effectively, hold the tablet in your mouth until it dissolves, then drink it with a sufficient amount of water. You can also dissolve the medicine with water or other beverages to make it easier to take. Nykob 5mg should be used immediately after removing the drug from the blister because the tablet is very fragile. It is recommended to take the medicine at a fixed time of the day to ensure the best effect. 3.2. Dosage Use Nykob 5mg as prescribed by your doctor. You can refer to the dosage of the drug in each case as follows:
Adults: Usually used with a starting dose of 10mg/day, taken once a day. Mania: In the monotherapy regimen used at a dose of 15mg/day. Maintenance in patients with bipolar disorder: Continue use at a dose-responsive dose in previously treated patients. In cases of new episodes of mania, depression, and mixed emotions, the physician will need to establish the optimal dose according to the clinical presentation. Basically the dose is maintained at 5 - 20 mg/day. Elderly, patients with liver failure, kidney failure: Use Nykob 5mg with a starting dose of 5mg/day.

4. Side effects when taking Nykob 5mg

During treatment with Nykob 5mg, patients may experience some of the following adverse reactions:
Common side effects: Weight gain, drowsiness, elevated blood prolactin levels. Common side effects: Eosinophils, high blood lipids, hyperglycemia, Glucoseuria, anxiety, Parkinson's, orthostatic hypotension. Patients also have appetite, dizziness, mild acetylcholine resistance, increased liver enzymes, rash, weakness, fatigue. Uncommon side effects: Leukopenia, bradycardia, thrombosis, photosensitivity, hair loss, urinary incontinence, urinary retention, amenorrhea, breast enlargement. In some cases, there are signs of increased Creatine Phosphokinase and total Bilirubin,... When side effects appear, you need to immediately notify your doctor for timely measures.

5. Drug interactions

During the use of Nykob 5mg, the drug may cause some of the following interactions:
The drug may reduce the effect when used with Olanzapine. When the drug is taken with alcohol and other CNS depressants, it can cause a dangerous increase in CNS depression. Nykob 5mg acts on CYP1A2 with the potential to change the bioavailability of Olanzapine, specifically inducers (including tobacco) increase metabolism, inhibitors (Fluvoxamine) increase accumulation in the body. Activated charcoal reduces the effectiveness of Nykob 5mg by 50-60%, so the two drugs should be taken at least 2 hours apart. Drugs that increase the QT interval have an increased risk of cardiotoxicity because olanzapine often causes QT prolongation. Before using Nykob 5mg, you need to inform your doctor about the drugs and supplements you are using for the most effective and appropriate treatment.

6. How to handle missed dose, overdose Nykob 5mg

In case you miss a dose, you can make up for it if it is still far from the time of your next dose. If the time to remember is close to the next dose, you can skip it, absolutely do not take a double dose.
If you take an overdose of Nykob 5mg, you may notice some symptoms such as tachycardia, anger, extrapyramidal symptoms, impaired consciousness or allergies. At this point, contact your doctor or pharmacist immediately for supportive treatment.
Usually, the patient can wash the intestines, drink activated charcoal for emergency treatment. Absolutely do not apply measures such as induce vomiting, beta-sympathomimetic drugs (Epinephrine, Dopamine,...) because they can aggravate hypotension.

7. Can the drug be used by pregnant and lactating women?

7.1. Pregnancy Not much is known about the effects of the drug on pregnant women. However, some reports have shown that taking the drug in the third trimester may increase the risk of extrapyramidal symptoms and some other side effects in the baby at birth. In which, there are common signs of agitation, increased tone, decreased tone, tremor, drowsiness, respiratory failure, eating disorder. Therefore, if a pregnant woman uses Nykob 5mg during pregnancy, the newborn baby should be carefully monitored.
7.2. Lactation: In a study in healthy and lactating women, the drug was excreted in milk, at 1.8% of the maternal dose. Therefore, patients are advised not to breast-feed during treatment with Nykob 5mg or to discontinue breast-feeding if the drug must be taken.

8. Some notes when using Nykob 5mg

Nykob 5mg can cause dizziness, drowsiness, so users need to be careful when driving, operating machinery and participating in other activities that require concentration. Read the instructions carefully before use, if need to stop the drug need to reduce the dose gradually. Caution should be exercised when administering the drug to patients under 18 years of age as safety and efficacy have not been established. Use caution when using the drug for patients with prostate enlargement, paralytic ileus, liver failure, and leukopenia. People over 65 years of age need to monitor blood pressure during treatment because of the risk of sudden hypotension. Store the medicine at a temperature below 30 degrees Celsius, in a cool, dry place and out of the reach of small children. Above is some basic information about the drug Nykob 5mg that readers should learn before using. The use of the drug must be strictly followed the instructions, the allowed dose to bring the best effect in the treatment of the disease.
Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.

Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.