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Notrixum is a muscle relaxant commonly used in surgical cases involving intubation. The drug is used to support general anesthesia, relax skeletal muscles and enhance mechanical ventilation. The drug can be used for adults and children over 1 month old.
1. What is Notrixum?
Notrixum is a drug used to support general anesthesia, to help the process of endotracheal intubation go smoothly and conveniently. In addition, the drug also has a muscle relaxant effect during surgery, helping to control ventilation. controlled to facilitate mechanical ventilation in critically ill patients.Notrixum is on the ETC list of prescription drugs.
The main ingredient of the drug is atracurium besylate 25mg/2.5ml.
Dosage form: solution for injection 10mg/ml, pack 2.5ml/tube, each box has 5 ampoules.
Dosage: notrixum is an intravenous drug.
For adults and children over 1 month old:
Parenteral route:
Dosage 0.3 to 0.6 mg/kg body weight. The drug relaxes muscles for 15 to 35 minutes after injection. Intubation case: 0.5 to 0.6 mg/kg body weight. The procedure is completed about 90 seconds after the injection. If long-term complete neuromuscular blockade is required, an additional dose of notrixum 0.1 to 0.2 mg/kg may be used. Infusion line:
In surgical procedures, patients requiring prolonged neuromuscular blockade, after an initial dose of 0.3-0.6 mg/kg, can be maintained by continuous infusion of notrixum with rate 0.3-0.6 mg/kg/hour until completion of surgery. In patients with indications for cardiopulmonary bypass surgery, infusion of drugs as prescribed by the doctor. Note at a temperature of 25 to 26 degrees Celsius, atracurium will be reduced inactivation rate. Therefore, for patients on hypothermia therapy who must maintain neuromuscular blockade, administer intravenous infusion at a rate equal to 1⁄2 of the initial dose. For the elderly:
Studies have proven that, if used in the right dose, Notrixum is safe for the elderly. A low dose and slow infusion rate is recommended.
Patients with impaired liver and kidney function:
Clinical practice shows that, at standard doses, notrixum can be used even in patients with end-stage renal failure.
Patients with cardiovascular disease:
Recommended initial dose within 60 seconds.
Patients in intensive care:
Initial dose: 0.3 - 0.6 mg/kg. Dose to maintain nerve block: 0.65 - 0.78 mg/kg/hour. This rate can increase or decrease, changing hourly according to the patient's condition. Uses of Notrixum:
Support for general anesthesia during intubation. Skeletal muscle relaxation in surgery. Support mechanical ventilation in critically ill patients. Possible side effects:
The drug has the ability to cause histamine release, so it leads to some common undesirable effects such as skin redness, hypotension, bronchospasm. In patients with a sensitive and weak body, some serious side effects may occur such as: allergic reactions, prolonged paralysis. The drug Notrixum is a muscle relaxant, so if used continuously for a long time, it will cause muscle weakness, especially in patients who are used in combination with corticosteroid therapy. In rare cases, anaphylaxis, convulsions...
2. Indications and contraindications of Notrixum
Indications to use notrixum drug in the following cases:Patients on mechanical ventilation. Support in anesthesia with intubation, muscle relaxation in surgery. Contraindications:
Patients with a history of allergy or hypersensitivity to any component of the drug. Person must drive or operate machinery. Do not use in children under 1 month of age. Notes when using Notrixum:
It is recommended to combine Notrixum with an appropriate general anesthetic to avoid increasing the risk of respiratory muscle paralysis. During the use of the drug, it is necessary to closely monitor the specialist and medical staff, pay special attention to the function of the neuromuscular system, change the dose when necessary. Because the drug has a histamine-releasing effect, caution should be exercised in patients with a history of sensitivity to the effects of histamine. For vagal and ganglion blockade, the drug has very little effect. Patients with burns are at risk of developing drug resistance, so the dose of notrixum used in these cases depends on the extent and duration of the burn. In people at risk for hypotension, the drug should be administered over a 60-second interval. When combined with other drugs for the same intravenous line, rinse the vein with a small amount of 0.9% sodium chloride infusion solution after each drug, especially notrixum. Do not administer the same line as blood transfusion because atracurium besylate is a hypotonic. Consult a specialist when you want to use the drug on pregnant and lactating women. If you miss a dose, take it as soon as you remember, do not take a double dose to make up for the missed dose. In case of an overdose of notrixum, contact your doctor or go to the nearest medical facility for timely assistance in dealing with possible symptoms. The medicine should be kept out of reach of children, in case the child takes it or breaks the tube, the broken pieces will injure the child. In most cases, notrixum is used for very quick results. However, the drug also has many side effects. In particular, the drug is not suitable for infants, pregnant and lactating women. Please consult your doctor in case you need to take medicine to avoid unwanted effects that affect your health.
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