1. What medicine is Nospa 40mg?
Nospa medicine 40mg is made in a tablet shape or solution for injection, with the main ingredients including:
Active ingredients: Drotaverine hydrochloride 40 mg.
Excipients:
- Tablets: Lactose monohydrate, Talc, Corn starch, and Magnesium stearate.
- Solution for injection: Sodium metabisulfite, Distilled water for injection, Alcohol, and Carbon dioxide.
Pharmacodynamics of Nospa 40mg
In our body, the enzyme Phosphodiesterase-4 (PDE4) inhibits the contractility of smooth muscle, and Phosphodiesterase-3 (PDE3) hydrolyzes cAMP in the myocardium and the muscle in the blood vessels.
Drotaverine is a derivative of Isoquinoline, which selectively inhibits PDE-4, not enzymes of the same group like PDE-3. Therefore, Drotaverine can be effectively applied in the treatment of hypermotility disorders and diseases associated with gastrointestinal, urinary, genitourinary or vascular smooth muscle spasms without adverse effects on the myocardium.
The effect of Drotaverine is independent of the distribution of the autonomic nervous system on the muscles of the gastrointestinal tract, biliary tract, urinary system, genitourinary system,and blood vessels.
2. How Nospa 40mg affect human's body?
Nospa medicine 40mg is indicated for the treatment of the following cases:
Reduce biliary smooth muscle spasm encountered in gallstones, peri-gall bladder inflammation, cholecystitis, cholangitis, pancreatic ball.
Treatment of renal colic pain due to smooth muscle spasm in kidney stones, ureteral stones, pyelonephritis, pyelonephritis, cystitis, bladder spasms.
Support the treatment of gastrointestinal smooth muscle spasms such as spasms in peptic ulcer disease, stomach, pylorus, colon spasms, constipation and other forms of abdominal distention caused by irritable bowel syndrome, enteritis, and colitis.
Reduce smooth muscle spasms in obstetric and gynecological diseases such as abdominal pain in threatened miscarriage, dysmenorrhea…
3. Contraindications of Nospa 40mg
Nospa 40mg drug is contraindicated in the following cases:
Hypersensitivity to any ingredient of Nospa 40mg drug.
History of allergy to Drotaverine.
People with impaired liver function, severe kidney function. People with severe heart failure with a low ejection fraction.
Cardiovascular conduction disturbances such as first degree atrial block II-III.
Children < 1 year old
4. Dosage and usage of Nospa 40mg
In each form, there will be different ways to use Drotaverine, which are:
4.1. Injections
Adults’ dose: Intramuscular injection 1-2 ampoules (40mg)/time x 1-3 times/day.
Dose to relieve gastrointestinal or urinary colic: Intravenous injection 1-2 ampoules (40-80mg)/time x 1 time/day.
For children : Injection is not recommended.
4.2. Tablets
For adults: Take 1-2 tablets (40 - 80mg)/time x 3 times/day.
For children 1 - 6 years old: Take 1⁄2 - 1 tablet (20-40mg)/time x 2 - 3 times/day.
For children > 6 years old: Take 1 tablet (40 mg)/time x 2-3 times/day.
Note: The intravenous route is only used in acute pain with severe severity. The drug should be mixed with distilled water before injection and injected at a slow rate. Before using, consult a doctor.
5. Side effects of Nospa 40mg
Using Nospa 40mg in high doses or for a long time can cause rare side effects such as:
Digestive disorders: Nausea, vomiting, constipation or diarrhea. diarrhea. Nervous disorders: Headache, dizziness, insomnia.
Cardiovascular disorders: Hypotension, palpitations.
Immune disorders: Allergic hypersensitivity such as urticaria, angioedema, erythema, pruritus. Severe can lead to anaphylaxis.
If there are any of the above symptoms or other undesirable symptoms after using Nospa 40mg, the patient should immediately visit a doctor or go to the nearest healthcare facility for timely treatment
6. Precautions of Nospa 40mg
Caution should be taken when using Nospa 40mg in the following cases:
People with current or history of hypotension, people with rare disorders such as Galactose intolerance, Glucose-Galactose malabsorption, or Lactase deficiency caused by tablet form with lactose as an excipient.
Pregnancy: Studies have shown that Drotaverine does not increase the risk of fetal abnormalities. Clinically, it is still possible to use Nospa 40mg on those but must be approved by a doctor specializing in obstetrics and gynecology.
Women on breastfeeding: There is limited data on the effects of Drotaverine in this population, so Nospa 40mg should not be used on those.
Drivers or machine operators need to be careful when using Nospa 40mg, because they may experience side effects such as headache, dizziness or insomnia.
7. Drug interactions of Nospa 40mg
Levodopa: Nospa 40mg reduces the effect of Levodopa in the treatment of symptoms in Parkinson's disease. In addition, to avoid drug interactions, patients need to list the herbs, drugs, and dietary supplements they are using.
Above is an overview of ingredients, uses, doses, and notes when using Nospa 40mg. In order to bring about the best treatment, patients should carefully read the instructions for use on the package and strictly follow the instructions of doctors.
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