Uses of nomigrain

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Nomigrain 5mg is a drug indicated for use in the treatment and prevention of migraine, vestibular disorders, memory disorders,... Before and during the use of the drug, patients should strictly adhere to the following instructions. Your doctor's instructions on the dose and timing of medication to achieve optimal therapeutic benefit.

1. What is Nomigrain 5mg?

Nomigrain 5mg is a drug used mainly for the prevention and treatment of patients with migraine attacks. Nomigrain is prepared in the form of capsules with packaging of 5 blisters x 20 tablets. In each Nomigrain capsule includes the following ingredients:
Main ingredients: Active ingredient Flunarizine HCl with 5mg content. Other excipients are enough for one tablet: Talc, Starch, Lactose, Magnesium stearate and Dibasic calcium phosphate (anhydrous).

2. Indications and uses of Nomigrain 5mg

2.1. Indications for the use of Nomigrain 5mg

Nomigrain 5mg is usually indicated for use in the following cases:
Prophylaxis and treatment of patients with migraine. Treat and relieve symptoms of vestibular disorders such as dizziness, tinnitus or dizziness. Helps to significantly reduce symptoms of inattention, sleep disturbances, agitation, memory disorders. Treatment of muscle spasticity when lying / walking, cold extremities, paresthesia.

2.2. Uses of Nomigrain 5mg

Pharmacodynamics Nomigrain drugs have the ability to inhibit the flow of calcium into the cells of the body, helping to prevent cell damage caused by calcium overload. Thanks to this mechanism, Nomigrain is classified as a calcium overload inhibitor. In addition, the drug Nomigrain also inhibits smooth muscle contraction due to the action of extracellular calcium. Nomigrain can significantly reduce the consequences of hypoxia in brain cells, and at the same time reduce the stiffness of red blood cells caused by calcium overload. On the other hand, Nomigrain also has vestibular inhibitory, anticonvulsant and antihistamine effects.
Pharmacokinetics According to studies, the peak plasma concentration of Nomigrain usually occurs 2 - 4 hours after oral administration. The drug, when entering the body, will be widely distributed throughout the tissues, then metabolized by N-dealkyl oxidation, Glucuronic conjugation and aromatic hydroxylation. Nomigrain 5mg is excreted mainly in the bile with a half-life ending within 18 days in healthy subjects.

3. Dosage and how to use Nomigrain 5mg

3.1. Dosage of Nomigrain 5mg

The recommended dose of Nomigrain will be determined based on the age and medical condition of the patient. Specifically:
Dose for patients under 65 years of age and elderly people (> 65 years old)
The recommended dose of Nomigrain is 5mg/day, maintained continuously for 4 - 8 weeks and used in the evening. During treatment with Nomigrain 5mg, if you notice the appearance of extrapyramidal symptoms, depression or other serious health events, the patient should stop using the drug and notify the doctor.
In case no improvement is observed after 8 weeks of treatment with Nomigrain, this is considered as non-responsive to treatment and should be discontinued. According to the doctor, the duration of treatment with Nomigrain 5mg should not be longer than 6 months.
It is recommended that for patients aged 65 and under 65 years who exhibit an inadequate response to therapy, the physician may increase the dose up to 10 mg/day, however, dose adjustment should be considered within the range of possibilities. patient's drug tolerance.
Dosage for children
For children over 12 years old: Take Nomigrain 5mg/day in the evening and treat for 6 months. For children under 12 years of age: Nomigrain 5mg should not be used in children under 12 years of age.

3.2. How to use Nomigrain 5mg

Nomigrain 5mg is in capsule form and should be taken orally. Patients should take the drug with water / white water in the evening, avoid drinking with other types of water such as carbonated water, soft drinks, milk or stimulants. These drinks can reduce the effectiveness of the drug, leading to a decrease in the effectiveness of the treatment.

4. What to do when taking an overdose or forgetting a dose of nomigrain 5mg?

4.1. How to handle an overdose of Nomigrain 5mg

The use of Nomigrain up to 600 mg/time may lead to symptoms of overdose affecting the central nervous system and cardiovascular system such as confusion, somnolence, apathy or tachycardia. When the above symptoms of overdose occur, the patient should be given first aid as soon as possible and treated with methods such as inducing vomiting, using activated charcoal, gastric lavage or some other supportive treatment measures.

4.3. What to do when you miss a dose of Nomigrain 5mg

When trott missed a dose of Nomigrain 5mg, the patient can take the medicine as soon as possible. However, if the missed dose is too close to the time for your next dose, skip the missed dose and follow the schedule prescribed by your doctor. Note that do not double the prescribed dose as this may lead to accumulation of Flunarizine HCl in the body.

5. In which case is the use of Nomigrain 5mg contraindicated?

Here are some cases where Nomigrain should not be used, including:
People who are allergic to Flunarizine or are hypersensitive to any of the excipients of the drug. Patients with a history of extrapyramidal syndrome. People with symptoms of Parkinson's disease before starting treatment with Nomigrain 5mg. People with depression or have ever had recurrent depressive syndromes.

6. Some side effects when using Nomigrain 5mg

During the use of Nomigrain 5mg, patients may experience some unwanted reactions such as:
Fatigue or mild drowsiness (accounting for 20%). Increased appetite or increased body weight (11%). Depression is particularly high in female patients with a history of depression. Presence of extrapyramidal symptoms such as rigidity, slowness of movement, tremor, restlessness or dyskinesia. These symptoms may occur in elderly patients. Digestive problems such as nausea, a burning sensation in the breastbone, or stomach pain. CNS problems, including anxiety or drowsiness. Dry mouth, increased lactation, rash or muscle pain (rare).

7. What drugs does Nomigrain 5mg interact with?

The drug Nomigrain 5mg when used in combination with some other drugs may lead to an interaction that reduces the effect of the drug. Specifically:
Anticonvulsants when co-administered with nomigrain may decrease steady-state concentrations of Flunarizine. Concomitant use with alcohol, sedatives or narcotics may lead to persistent drowsiness. Flunarizine does not affect the pharmacokinetics of Carbamazepine, Phenytoin or Valproic acid, but may reduce plasma concentrations of Mephenytoin.

8. Some other notes when using and storing Nomigrain 5mg

8.1. Some cautions when using Nomigrain 5mg

Here are some things that patients need to be careful about when using Nomigrain 5mg, including:
People with low blood pressure, elderly or impaired kidney function need to be careful when taking Nomigrain. Minimize the use of drugs for people who have to drive vehicles, operate machinery and pregnant women. Patients need to strictly follow the instructions on the dose recommended by the doctor during treatment, avoid arbitrarily increasing / decreasing the dose for personal purposes. People with chronic diseases that require long-term medication (such as allergies or heart disease) should notify their doctor for advice and adjust the dose if necessary. It is necessary to minimize alcoholic beverages, stimulating foods during the treatment period. Consult a specialist before deciding to stop using Nomigrain 5mg. When the drug has expired or shows strange signs on the medicine such as discoloration, mold or watery discharge, the patient should avoid using the medicine again.

8.2. How to store Nomigrain 5mg

You need to store Nomigrain 5mg in a dry place, avoid storing it in an area with high humidity or in direct sunlight. In addition, the drug also needs to be placed in a high place, avoid being near the place where children play, easily reach and accidentally drink.

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