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Nifedipine T20 is a medicine to treat high blood pressure and prevent angina pectoris, belongs to a group of calcium channel blockers that work by the mechanism of dilating blood vessels, helping to reduce blood pressure on arteries, blood circulation more easily. The following article will provide you with detailed information about the uses of Nifedipine T20.1. What is Nifedipine T20?
Nifedipine is a calcium channel blocker that belongs to a class of drugs used to treat high blood pressure. The drug has a relatively selective mechanism on vascular smooth muscle, with little effect on cardiomyocytes. The action of nifedipine is to selectively inhibit the influx of calcium ions into the cell, by specifically interacting with the calcium channel in the cell membrane. Therefore, at therapeutic doses the drug does not have a direct effect on cardiac contractility and conduction.2. Uses of Nifedipine T20
What is Nifedipine T20 used for? Nifedipine T20 is usually used in the following cases:
Prophylactic angina, typically pain caused by vasospasm. Treatment of hypertension.
3. Dosage – How to take Nifedipine T20
Nifedipine T20 is produced in the form of round tablets, red film coated. Each tablet contains: Nifedipine 20mg and excipients. Therefore, the patient needs to take the drug orally.
Dosage of Nifedipine T20:
Preventive angina: 01 tablet x 02 times/day. Hypertension: 01 tablet x 02 times/day. Note:
The dose interval is 12 hours, minimum 4 hours, maximum dose 120 mg/day. The dose of Nifedipine is determined by your doctor based on your medical condition and response to treatment. With the initial dose should be explored gradually, then the doctor can gradually increase the dose to suit the body. Therefore, you need to follow your doctor's instructions carefully. How to take Nifedipine T20
Nifedipine T20 is taken orally. Patients should swallow the tablet whole, do not chew, break or crush. While taking Nifedipine avoid eating grapefruit and drinking grapefruit juice, as grapefruit can increase the amount of certain drugs in your blood. To help you remember to take your medicine, you should take it at the same time each day. Besides, should be used regularly and regularly to achieve the best treatment effect. In case of overdose of Nifedipine T20
When using an overdose of Nifedipine T20, patients often appear symptoms such as: headache, dizziness, nausea, low blood pressure, hypokalemia, atrioventricular block,... In this case, it is necessary to quickly bring the patient to the nearest medical facility for timely treatment. Therefore, when using Nifedipine T20, patients need to consult with qualified doctors / pharmacists, use exactly as prescribed by the doctor. Carefully read and follow the exact dose indicated on the prescription or drug leaflet. In case of overdose of Nifedipine T20, you should immediately notify your doctor or pharmacist if you have any unusual symptoms. If there are signs of more serious damage such as: confusion, coma, convulsions, etc., immediately contact 911 emergency center for instructions or take the patient to a nearby medical facility immediately. to have a timely treatment plan. Missing a dose of Nifedipine T20:
When you miss a dose take it as soon as possible. When you miss a dose and it is almost time for your next dose, skip the missed dose. Use your next dose of Nifedipine at that time, do not double the usual dose.
4. Contraindications to the use of Nifedipine T20
During the use of Nifedipine T20, it is necessary to note the following contraindications:
Cardiogenic shock. Severe aortic valve stenosis. Heart attack. Acute pain in chronic stable angina, unstable angina. Porphyria metabolism disorder.
5. Nifedipine T20 . Side Effects
During treatment with Nifedipine, you may experience headache, dizziness, flushed face, weakness, constipation. If any of the side effects of Nifedipine persist or make your body uncomfortable or worse, tell your doctor right away.
In rare cases, patients with a history of previous severe heart disease may experience worsening chest pain or heart attack after starting this medicine or increasing the dose. Get medical help right away if you experience the following symptoms: worsening angina, difficulty breathing, blue lips,...
A very serious allergic reaction is very rare. Nifedipine: rash, itching, urticaria, shortness of breath, dizziness. In this case, it is necessary to quickly bring the patient to the nearest medical center.
Below are the possible Nifedipine T20 unwanted side effects (ADRs).
Ankle edema, headache, fatigue, dizziness, hot flushing. Palpitations, heart palpitations. Gastrointestinal: Nausea, diarrhea or constipation. Low blood pressure, aggravation of angina. Rash, urticaria, itching. Blood: Agranulocytosis. Circulatory: Extrasystoles, syncope. Endocrine: Endocrine disorders are common in men with gynecomastia. Teeth - Jaws - Face : Hypertrophy of teeth and gums. Dermatology: Atopic dermatitis. Liver: Increased liver enzymes. Respiratory: Difficulty breathing. Metabolic disorders: Increased blood glucose. Musculoskeletal: Muscle pain, joint pain, tremor. Nervous: Paresthesia. Psychiatric: Confusion, sleep disturbance, nervousness.
6. Notes and cautions before taking Nifedipine T20
Things to note before taking Nifedipine T20: After starting treatment with Nifedipine T20, ischemic pain appears or the existing pain worsens rapidly, at this time the patient needs to stop medicine. Use with caution in patients with a history of heart failure or impaired left ventricular function. It is necessary to reduce the dose of Nifedipine T20 in patients with liver damage and diabetes. Avoid grapefruit juice in patients taking nifedipine. Nifedipine may inhibit labor. Pregnancy: Animal studies have shown that nifedipine is fetotoxic and teratogenic, most commonly bone deformities. Therefore, it should not be used by pregnant women unless absolutely necessary. Lactation: Because nifedipine reaches high concentrations in breast milk, adverse events may occur in nursing infants even at normal doses. Therefore, the benefits and risks of the drug to the mother should be weighed.
7. Nifedipine T20 drug interactions with other drugs
It should be noted when using some of the following drugs in combination with Nifedipine T20, due to possible interactions, such as:
H2-Histamine receptor antagonists: When used concurrently with nifedipine, the effect will be increased. of nifedipine, the dose should be reduced when combined. Beta-blockers: May cause excessive lowering of blood pressure, increase angina, and are common in patients with a history of concomitant cardiovascular disease. Alpha-blockers: Alpha-blockers, when used with Nifedipine T20, may potentiate the antihypertensive effect because nifedipine inhibits the metabolism of prazosin, so caution should be exercised. Calcium channel blockers: Will reduce the metabolism of Nifedipine T20. Digoxin: Used in the treatment of cardiovascular disease, when combined with Nifedipine, it will increase the serum concentration of digoxin by about 15 - 45%, so the dose must be reduced and other signs monitored. Fentanyl: If high doses of fentanyl are required during surgery, nifedipine should be withheld at least 36 hours prior to surgery, if the patient's condition permits. Because it will cause a rapid drop in blood pressure. Theophylline: Used in the treatment of respiratory diseases, when combined with Nifedipine reduces the concentration of theophylline in the blood plasma. Rifampicin: Rifampicin reduces plasma concentrations of nifedipine and increases episodes of angina. Therefore, these two drugs should not be used together. Grapefruit juice: When grapefruit juice is taken with nifedipine, the antihypertensive effect of nifedipine is increased. Alcohol: Alcohol enhances the antihypertensive effect of nifedipine and inhibits its metabolism. Above is some information about the use of Nifedipine T20, if you need advice or have any questions, please consult a qualified doctor / pharmacist for answers. and best advice.
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