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Newgenasada is a topical medicine originating from Korea, often indicated for use to improve many different skin problems. So what effect does Newgenasada have?
1. What is Newgenasada topical?
Newgenasada drug is a drug manufactured by Korea Arlico Pharm company, Korea. Newgenasada topical has the main active ingredients including Betamethasone, Clotrimazole, Gentamicin with the following content:
Betamethason (Betamethasone dipropionat): 0.64mg content - this is a form of synthetic corticosteroid with quite strong activity; Clotrimazol:100mg - active ingredient with antifungal properties; Gentamicin (Gentamicin sulfate): 16.7mg - Antibiotics have strong effects on gram-negative aerobic bacteria, gram-positive bacteria, streptococcus, in addition, the drug also acts on some types of pneumococci and staphylococcus bacteria. Newgenasada topical medication is prepared in the form of a skin cream, box of 1 tube of 10g.
2. What is the use of Newgenasada topical?
Newgenasada topical is indicated for use in the following cases:
Allergic skin diseases: Eczema, contact dermatitis, atopic dermatitis, diaper rash, sunlight contact dermatitis, psoriasis , itchy; Hair loss; 1st degree burns; Insect bite; Dermatitis due to superinfection; Skin fungus: tinea pedis, tinea pedis, scalp fungus, tinea pedis...
3. Pharmacodynamics of ingredients in Newgenasada topical ointment
Betamethasone is an active ingredient in the group of anti-inflammatory corticosteroids. This active ingredient has been shown to be effective in the treatment of local corticosteroid-responsive inflammatory skin conditions, thanks to Betamethasone's mechanism of anti-inflammatory, antipruritic, and vasoconstrictor action.Clotrimazol is an antifungal active ingredient that acts by changing the permeability of the cell membrane, the drug will bind markedly with the phospholipids in the fungal cell membrane to change the permeability of the membrane. In contrast to polyene antibiotics such as amphotericin B, the activity of the antifungal agent Clotrimazole is less dependent on the sterol content in the cell membrane. After a change in permeability, the fungal cell membrane becomes no longer able to act as an ion-selective barrier, and potassium and other cellular components are lost.
Gentamicin is a bactericidal antibiotic whose exact mechanism of action has not yet been determined. This drug is thought to inhibit protein synthesis in susceptible bacteria through irreversible binding to the 30S ribosomal subunit.
4. Pharmacokinetics of the drug Newgenasada
Topical betamethasone can be absorbed through the skin, inflammatory conditions or other skin conditions may increase the extent of absorption of topical corticosteroids. If the dressing is to cover the skin surface, the percutaneous absorption of topical corticosteroids will be increased.
Clotrimazol used topically has the ability to penetrate the epidermis, however systemic absorption occurs rarely.
Gentamicin: Systemic absorption of this active ingredient and other aminoglycosides has been cautioned when used topically on exposed, burned, wounded skin... In vivo, gentamicin and other aminoglycosides diffuse mainly weak into extracellular fluids, little diffusion into the cerebrospinal fluid even when the meninges are inflamed... Aminoglycosides diffuse rapidly into the inner ear fluid, cross the placenta, and a small amount of the drug is released. present in breast milk. The plasma half-life of gentamicin ranges from 2 to 3 hours, however this may be longer in neonates and in patients with renal impairment.
5. Dosage of Newgenasada topical medication
Newgenasada topical is used topically with the following dosage:
It is recommended to apply a thin layer of Newgenasada topical to cover the entire surface of the infected skin and around it, apply twice daily, morning and evening. . In order for Newgenasada topical to work well, it is necessary to use it regularly. The duration of Newgenasada topical therapy depends on the extent and location of the diseased skin and the patient's response, if there is no clinical improvement after 3-4 weeks, it is recommended to consult a doctor to review. should continue treatment with this drug or not.
6. Newgenasada topical side effects
When using Newgenasada topical, you may experience the following undesirable effects:
Side effects of Newgenasada topical on the skin: Rarely cystitis, boils, skin irritation, irritation, fever, burning. , rash, skin redness, itching, dryness, allergic contact dermatitis, millet disease, pustular disease... then stop taking the drug and consult a doctor; Side effects of Newgenasada topical during long-term treatment: During long-term treatment with Newgenasada, skin atrophy, capillary dilation, purpura, ichthyosis, hirsutism, dyschromia may occur; Endocrine system: Large doses and long-term treatment may lead to hypothalamus and impaired adrenal cortex function; Side effects of Newgenasada topical on the eye: glaucoma may occur; Superinfection: Infection is a possible condition caused by strains of bacteria that are not sensitive to antibiotics, in which case the drug should be discontinued.
7. Contraindications of topical Newgenasada
Newgenasada topical is contraindicated in the following cases:
History of hypersensitivity to any component of Newgenasada topical; Apply to open wounds or mucosal areas; Bacterial infections caused by tuberculosis bacteria, syphilis, candida, trichophyton, herpes simplex virus, herpes zoster, parasitic dermatitis... Skin ulcers (including behcet's disease), burns above 2 degrees; Perioral dermatitis, common acne, rosacea; History of hypersensitivity reactions to Bacitracin, Aminoglycoside antibiotics or neomycin.
8. Can I use Newgenasada topical during pregnancy and lactation?
Because the safety of topical corticosteroids used in pregnancy and lactation has not been established, they should be used during pregnancy only if the potential benefits outweigh the risks. for the unborn baby. If you are breastfeeding, you should also temporarily stop taking the drug or stop breastfeeding to avoid side effects.
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