Uses of Nesteloc 40

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1. Uses of the drug Nesteloc 40mg

What is Nesteloc 40? The main ingredient of the drug is esomeprazole. This is the S-isomer of omeprazole, which reduces gastric acid secretion by highly selective and irreversible binding to the proton pump.
Indications for using Nesteloc 40:
Treatment of gastroesophageal reflux - oesophagitis; Treatment of gastric and duodenal ulcers infected with Helicobacter Pylori (HP), prevention of recurrence of gastric and duodenal ulcers caused by HP; Prevention and treatment of gastric and duodenal ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs). Contraindications to using Nesteloc 40: People with a history of hypersensitivity to esomeprazole or other ingredients in the drug.

2. How to use and dose Nesteloc 40 mg

2.1. How to use: Nesteloc 40 is recommended to take the tablet whole, without chewing or crushing the microparticles. The drug should be taken before meals, preferably before breakfast.
2.2. Dosage: Gastroesophageal reflux syndrome: The starting dose is 20-40mg/day, can be treated for more than 4-8 weeks if the patient does not heal after 4-8 weeks. In the case of maintenance treatment or the disease has no symptoms of esophageal erosion, a dose of 20mg/day can be used; Stomach - duodenal ulcer with HP: With triple combination therapy including esomeprazole + amoxicillin + clarithromycin, the dose is 20mg esomeprazole x 2 times/day for 7 days or esomeprazole 40mg/time/day for 10 days; Peptic ulcer - duodenum caused by NSAID: Dosage is 20mg or 40mg x 1 time / day for 6 months; Hepatic Impairment: No dose adjustment is required for patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the dose of esomeprazole kongo should exceed 20 mg/day. 2.3. Overdose There have been no reports of overdose with esomeprazole in humans. There is no specific antidote for drug overdose. In case of overdose, the patient is treated symptomatically and general supportive measures are used.
2.4. Missed dose If a dose of Nesteloc is missed, the patient should take it as soon as possible. If it is almost time for the next dose, skip the missed dose, take the next dose at the scheduled time, do not need to double the prescribed dose.

3. Side effects of Nesteloc 40mg

When using Nesteloc 40, you may experience some unwanted side effects:
Common: Headache, dizziness, abdominal pain, constipation, diarrhea, flatulence,...; Uncommon: Dermatitis, itchy skin, urticaria, dizziness, dry mouth,...; Rare: Hypersensitivity reactions including urticaria, angioedema, anaphylaxis, bronchospasm, fever with sweating, photosensitivity, peripheral edema,...; Very rare: Agranulocytosis, thrombocytopenia, leukopenia, increased liver enzymes, liver failure, hepatitis, interstitial nephritis, myalgia, arthralgia,... When experiencing side effects of Nesteloc 40mg The patient should stop taking the drug and immediately notify the doctor or go to the nearest hospital for timely treatment.

4. Be careful when using Nesteloc 40mg

Before and while using Nesteloc 40mg, users should note:
When there are symptoms such as unintentional weight loss, recurrent vomiting, vomiting blood, difficulty swallowing, black or bloody stools, or If peptic ulcer is suspected, it should be checked and excluded the possibility of malignancy because treatment with esomeprazole can reduce symptoms, delay diagnosis; Use caution when taking Nesteloc for a long time because it can cause atrophic gastritis; Use caution when using Nesteloc for children under 18 years old; Patients with renal failure when taking Nesteloc drug do not need to adjust the dose but should be careful when using the drug for people with severe renal impairment; Some cases of dizziness, lightheadedness, headache when using esomeprazole should be careful when using the drug while driving, operating machinery; The drug Nesteloc does not affect the development of the fetus in humans but only used in pregnant women when absolutely necessary; Nesteloc should not be used in women who are breastfeeding.

5. Nesteloc 40mg . drug interactions

Some drug interactions of Nesteloc 40mg include:
Esomeprazole (the main ingredient of Nesteloc drug) inhibits acid secretion, increases gastric pH, so the drug may affect the bioavailability of some absorbed drugs. of gastric pH such as: Digoxin, ketoconazole, iron salts; Concomitant use of esomeprazole , clarithromycin and amoxicillin increases blood levels of esomeprazole and 14 - hydroxy clarithromycin; Esomeprazole pharmacokinetic interaction with drugs metabolized by the cytochrome P450 isoenzyme CYP2C19 in the liver; Concomitant administration of 30 mg esomeprazole and diazepam resulted in a 45% decrease in clearance of diazepam; Esomeprazole may increase blood levels of saquinavir and decrease levels of nelfinavir and atazanavir. Therefore, consideration should be given to reducing the dose of saquinavir when co-administered with esomeprazole to avoid possible adverse effects of saquinavir; Esomeprazole reduces the activity of enzymes that convert clopidogrel to the active form, thereby reducing clopidogrel activity. Therefore, use the combination of these two drugs only when absolutely necessary; Esomeprazole increases the concentration of cilostazol and its metabolites. The dose of cilostazol should be reduced from 100 mg twice daily to 50 mg twice daily when co-administered with esomeprazole. When using Nesteloc 40mg, the patient should follow all instructions given by the doctor about the dose, how to use it, ... At the same time, the patient should inform the doctor about the health history, the drugs they are taking. , ... to be adjusted appropriately, avoiding unpredictable risks.

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