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Nerazzu hct medicine has the main active ingredient as Losartan potassium and Hydrochlorothiazide as the active ingredient. The drug is useful in the treatment of high blood pressure. So how should Nerazzu hct 50mg be used?
1. What is Nerazzu-hct drug? The effect of the drug Nerazzu hct
Nerazzu-hct 50mg medicine contains the main ingredient Losartan potassium 50mg; Hydrochlorothiazide 12.5mg, other active ingredients and excipients just enough for 1 tablet.
Losartan Potassium is the first agent of a new class of drugs used in the treatment of hypertension, which is an antagonist at the angiotensin II receptor (type AT1). It is also effective in reducing the combined risks of cardiovascular death, stroke, and myocardial infarction in hypertensive subjects with left ventricular hypertrophy and protecting the kidneys in patients with hypertension. type 2 diabetes with proteinuria. Hydrochlorothiazide is relatively rapidly absorbed, about 65-75% of the dose, but this rate may be reduced in people with heart failure. Hydrochlorothiazide crosses the placental barrier, is distributed and reaches high concentrations in the fetus. The diuretic effect appears about 2 hours after taking the drug, reaches its maximum concentration after 4 hours and lasts about 12 hours. The drug accumulates in erythrocytes.
Hydrochlorothiazide is eliminated mainly by the kidneys, mostly as unchanged drug. The mean half-life of jydrochlorothiazide is about 9.5 -13 hours.
2. What disease does Nerazzu hct treat?
Drug Nerazzu Hct indicated in the treatment of hypertension. It can be used alone or in combination with other antihypertensive drugs (eg, thiazide diuretics).
Losartan should be used in patients who cannot tolerate ACE inhibitors. Losartan is also being tested in the treatment of heart failure.
3. Usage and dosage of Nerazzu hct
3.1. How to use Nerazzu Hct: Nerazzu Hct film-coated tablets for oral use.
3.2. Dosage of the drug Nerazzu Hct Start taking 1 tablet of Nerazzu Hct (50mg/12.5mg)/day, after 3 weeks if still not controlling blood pressure, increase to 2 tablets/day. Do not exceed 2 Nerazzu Hct tablets/day.
The specific treatment dose depends on the individual's health condition and disease progression. To get the right therapeutic dose, you need to consult your treating doctor or medical professionals.
3.3. In case of forgetting/overdose In case of overdose: Data on overdose of Nerazzu Hct are limited. The most common symptom of overdose is probably hypotension and tachycardia may also be accompanied by bradycardia due to stimulation of the parasympathetic nerve also known as the vagus nerve. If symptomatic hypotension occurs, the doctor will prescribe supportive treatment. Neither the active substance Losartan nor its active metabolite can be removed by hemodialysis. In the case of using Nerazzu Hct drug overdose or taking too much medicine to have an emergency, family members need to bring the prescription/vial of medicine the victim has taken. In case of missed dose: It is still best to take Nerazzu Hct at the time prescribed by the doctor. Taking the medicine at the right time will ensure the best effect of the medicine. Normally, Nerazzu Hct can be taken 1 to 2 hours apart from the time prescribed by the treating doctor. Do not take it when the time is too far for the next dose.
4. Undesirable effects of the drug Nerazzu Hct
Common adverse effects with ADR > 1/100
Hypotension; Insomnia, dizziness; Increased potassium in the blood; Diarrhea, diarrhea, indigestion; Mild decrease in hemoglobin and hematocrit; Back pain, leg pain, muscle pain; Hypouricemia (when using high doses); Cough (less often with ACE inhibitors); Nasal congestion, sinusitis. Uncommon side effects with 1/1000 < ADR < 1/100
Orthostatic hypotension; Chest pain, grade II A-V block; Palpitations ; Cardiac arrhythmias: sinus bradycardia, tachycardia; Facial swelling, blushing; Anxiety disorders, confusion, depression, sleep disturbances; Migraine, headache; Alopecia, atopic dermatitis, dry skin, erythema, photosensitivity, pruritus, urticaria; Decreased sex drive Unwanted effects may not be the same, depending on the body of each person. Inform the doctor to treat the unwanted effects encountered when using Nerazzu Hct medicine.
5. Drug interactions of Nerazzu Hct
The drug Losartan does not affect the pharmacokinetics of oral or intravenous digoxin.
Co-administration of losartan with cimetidine increased the area under the concentration-time curve (AUC) for losartan by approximately 18%, but did not affect the pharmacokinetics of the active metabolite of losartan.
Co-administration of Losartan with Phenobarbital reduces the AUC of losartan and its active metabolite by approximately 20%.
There is no pharmacokinetic interaction between losartan and hydrochlorothiazide.
Drug interactions that can change the ability of the drug to work or increase the effect of possible unwanted effects. Tell your treating doctor or clinical pharmacist of all prescription and over-the-counter medicines, vitamins, minerals, herbal products, and medicines prescribed by other doctors. Always consult your treating physician.
Food, alcohol or tobacco can interact with certain medications. Please consult your treating doctor about taking Nerazzu Hct with food, alcohol and tobacco.
6. Some notes when using Nerazzu Hct
The drug should be used with caution under special supervision and/or at a reduced dose in those who are dehydrated, treated with diuretics and in whom other factors predispose to hypotension.
People with bilateral or unilateral renal artery stenosis, people with only one kidney are also at high risk of unwanted effects (increased creatinine and urea in the blood) and need to be closely monitored in treatment.
Patients with liver failure must take a lower dose.
Keep out of reach of children and pets in your family.
Ideally, you need to fully inform your treating doctor or pharmacist about your condition such as current medical condition, medical history, allergies, pregnancy, lactation....
Need Read the instructions carefully before using the drug to minimize the unwanted effects of the drug.
Above is all the important information about the drug Nerazzu Hct. Knowing the uses, doses, and storage will help the drug use process more effectively.
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