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Nalibigra 500 is an antibiotic with the main ingredient Nalidixic Acid 500mg. Let's find out what Nalibigra is and how to use it effectively and safely in the following article.
1. What is Nalibigra?
Nalibigra 500 medicine has the main ingredient is Nalidixic Acid 500mg. Nalidixic acid belongs to a group of broad-spectrum antibacterials, effective against most Gram-negative aerobic bacteria such as Proteus, E.coli, Klebsiella. Therefore, nalidixic acid is indicated in the treatment of urinary tract infections. Nalidixic acid does not affect the intestinal anaerobic bacteria, which is important for maintaining the ecological balance of the intestinal bacteria.
2. Indications of Nalidigra 500
Nalibigra 500 is indicated in the treatment of infections caused by susceptible bacteria such as E.coli, Proteus, Enterobacter, Citrobacter, Salmonella and Klebsielia in the following diseases:
Acute urinary tract infections: Nephritis, pyelonephritis , urethritis , cystitis . Uncomplicated recurrent infections due to gonococcal, Gram-negative intestinal infections: Bacillary dysentery, cholecystitis, enteritis.
3. Contraindications of Nalidigra 500
Nalibigra 500 is contraindicated in the following cases:
Hypersensitivity to Quinolone antibiotics; Patients who have had convulsions, renal failure, increased intracranial pressure, hematopoietic disorders, G6PD deficiency; Children under 3 months of age, pregnant women, lactating women, because nalidixic acid can cross the placenta and be excreted in breast milk.
4. Be careful when taking Nalidigra 500
Use caution when using Nalibigra 500 in patients with liver failure. Patients taking Nalibigra 500 should avoid direct sunlight because it can cause phototoxicity with blisters in case of sun exposure during and after treatment. Caution should be taken when using Nalibigra when driving or operating machinery because Nalibigra 500 can cause headaches, dizziness, visual disturbances.
5. Undesirable effects of the drug Nalidigra 500
Some undesirable effects of Nalibigra 500 are common such as nausea, vomiting, gastrointestinal disturbances, diarrhea, dizziness, headache, visual disturbances, itching, urticaria, reactions photosensitivity skin, angioedema, arthralgia, hemolytic anemia, thrombocytopenia/leukopenia, eosinophilia.
6. Drug interactions
Nalibigra drug increases plasma concentrations of Theophyllin , Cyclosporin and increases caffeine concentration; Co-administration of Nalibigra with Warfarin and derivatives, anticoagulants of the Coumarin group increases the effect of these drugs; Using Nalibigra 500 at the same time with gastric antacids containing magnesium, aluminum, calcium, sucralfate, cations with 2 and 3 valence such as zinc, iron can reduce the absorption of Nalibigra; Nitrofurantoin, Tetracycline, Chloramphenicol reduce the therapeutic effect of nalidixic acid; Probenecid reduces the therapeutic effect of Nalibigra in the treatment of urinary tract infections.
7. How to take Nalidigra 500
Adults: Initial dose: 2 tablets x 4 times/day, for 1 - 2 weeks. Treatment lasts more than 2 weeks, the dose is 2 tablets x 2 times / day, in the morning and in the evening. Children from 3 months to 12 years old: Initial dose: 55mg/kg body weight/day, divided into 4 times. For long-term treatment, the dose is 30mg/kg body weight/day. The above is important information about the uses, dosage and precautions when using Nalibigra 500. This is a prescription drug, patients do not arbitrarily use to ensure safety for health.
