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Myotalvic 50 belongs to the category of muscle relaxants and increases muscle tone. The drug is in the form of a film-coated tablet, packed in a box of 3 blisters x 10 tablets. Complying with the indications, the dose of Myotalvic 50 will help patients improve the effectiveness of treatment and avoid unwanted side effects.
1. What are the uses of Myotalvic 50?
Myotalvic 50 contains the main ingredient Tolperison Hydrochloride 50 mg or 150 mg.
Pharmacodynamics:
Tolperison in Myotalvic 50 is a centrally acting muscle relaxant with complex action. Thanks to its membrane stabilizing and local anesthetic properties, tolperisone can inhibit conduction in the primary nerve fibers and motor neurons of the patient. This helps to inhibit polysynaptic and single-synaptic reflexes. On the other hand, Tolperison also inhibits the influx of Ca2+ entering the synapse (an inhibitor of neurotransmitter release). In the brain stem, tolperison inhibits the reticular–spinal reflex. According to studies performed in animal models, tolperisone can reduce increased muscle tone and spasticity after brain loss. At the same time, Tolperison also helps to improve peripheral circulation. This effect may be related to the mild antispasmodic and anti-adrenergic effects of tolperison. Pharmacokinetics:
After oral administration, tolperison will be well absorbed in the small intestine. Peak plasma concentrations are reached 30 minutes to 1 hour after oral administration. Due to the strong first-pass metabolism, the bioavailability of Myotalvic 50 will be about 20%. High-fat meals can increase the bioavailability of oral Myotalvic 50 by up to 100% and increase peak serum concentrations by about 45% compared with a light meal. Peak concentrations are reached approximately 30 minutes after oral administration. In the human body, Tolperison is extensively metabolized by the liver and kidneys. It is eliminated mainly by the kidneys (over 99%) as metabolites. The pharmacological activity of the metabolite is currently unknown.
2. Indications of the drug Myotalvic 50
Myotalvic 50 is indicated for the treatment of:
Muscle spasticity after stroke in adults. Pathological musculoskeletal hypertonia in organic neurological disorders (multiple atherosclerotic lesions, pyramidal lesions, cerebrovascular accident, encephalitis or spinal cord disease...). Increased muscle tone, muscle spasms and spasms associated with movement diseases such as spinal rheumatism, spondylosis, lumbar and neck syndromes or arthropathy of the large joints). Rehabilitation for patients after trauma - orthopedic surgery. Treatment of thromboembolic diseases such as: Atherosclerotic vascular disease, thromboembolic vasculitis, diabetic vascular disease, disseminated scleroderma or Raynaud's disease. The syndromes appear on the basis of impaired neuro-vascular distribution such as acromegaly or episodic dyskinesia.
3. Contraindications of the drug Myotalvic 50
Myotalvic 50 is contraindicated in the following cases:
Patients with hypersensitivity to Tolperison components or substances with similar chemical structure to eperison and excipients contained in the drug. People with disabilities.
4. Dosage and how to use Myotalvic 50
How to use: Myotalvic 50 is taken orally.
Dosage:
For adults:
Recommended dose: From 150-450mg/day x 3 equal times. For people with renal and hepatic impairment: Information on the use of Myotalvic 50 in patients with renal and hepatic impairment is limited. However, there have also been cases of adverse events when using the drug in this group of subjects. Therefore, for people with moderate renal and hepatic impairment, it is necessary to determine the appropriate dose of Myotalvic 50 for each individual, depending on the response of the patient's body. At the same time, it is necessary to closely monitor liver and kidney function every day. The use of Myotalvic 50 is not recommended in patients with severe renal and hepatic impairment. For children:
Safety and effectiveness of Myotalvic 50 in children have not been established. Therefore, consult your doctor before use. Myotalvic 50 Overdose and Management:
Data on Myotalvic 50 overdose are rare because the tolperison component has wide therapeutic boundaries. The drug can be used in a maximum dose of up to 600mg without causing any serious symptoms of toxicity. However, in children, there have been reports of irritation after treatment with oral doses of 300-600mg/day. On the other hand, in the acute preclinical toxicity studies of Myotalvic 50, it was also shown that high doses of tolperisone can cause ataxia, dyspnoea, tonic-clonic convulsions and respiratory paralysis. Treatment: There is no specific antidote for Myotalvic 50. In case of overdose, supportive and symptomatic treatment should be given.
5. Side effects of the drug Myotalvic 50Myotalvic 50
Side effects when using Myotalvic 50 are mainly manifestations on the skin or subcutaneous tissue, disorders on the nervous system, body or digestive system.
Most side effects of Myotalvic 50 are not serious and are reversible once you stop taking them. Myotalvic 50 rarely causes hypersensitivity reactions.
In general, the effects of Myotalvic 50 are usually mild and moderate. However, serious side effects of Myotalvic 50 can still occur, so you should not be subjective. If you experience these symptoms, stop using Myotalvic 50 and notify your doctor for appropriate treatment.
6. Precautions when using Myotalvic 50
Use Myotalvic 50 with caution in people with a history of allergies, severe liver and kidney failure. Pregnant women should not use Myotalvic 50 during the first 3 months of pregnancy, unless the benefits outweigh the risks to the fetus. It is not known whether Myotalvic 50 passes into breast milk. Therefore, do not use this medicine while breastfeeding. Because Myotalvic 50 can cause dizziness, lightheadedness, so it should be used with caution for people who drive and operate machinery. If you experience dizziness, lightheadedness, seizures, loss of concentration, blurred vision or muscle weakness while taking Myotalvic 50, you need to consult your doctor to see if you can continue treatment. You need to read the instructions for use carefully before using Myotalvic 50. Absolutely do not use when Myotalvic 50 has signs of discoloration, mold, watery or expired. The article has provided information about Myotalvic 50 drug effects, dosage and notes when using. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Myotalvic 50 exactly as directed by your doctor. Store Myotalvic 50 in a dry place, the temperature is below 30 degrees Celsius and out of the reach of small children.
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