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Misenbo 125 is a widely available drug on the market, effective in treating pulmonary hypertension, improving exercise ability and reducing clinical morbidity. The following article gives readers a better understanding of this drug.
1. What is Misenbo 125?
Misenbo 125 contains Bosentan - an endothelin receptor antagonist. It works on proteins in your body that control blood flow to your lungs. This medicine dilates the arteries in your lungs and allows more blood to flow through. As a result, your heart can pump better, your body gets more oxygen, and you'll be able to breathe and exercise more easily.
2. How to use Misenbo 125?
The recommended starting dose is 62.5 mg twice daily (1 time in the morning and 1 time in the evening) for 4 weeks. After 4 weeks, the dose is increased to the recommended maintenance dose of 125mg twice daily. Misenbo 125 can be taken with or without food. It should be done consistently.
3. Uses of Misenbo 125
Misenbo 125 cure what? This medication is used to treat pulmonary arterial hypertension, which is high blood pressure in the blood vessels between the heart and lungs. Bosentan works by blocking the effects of a natural compound called endothelin, a substance the body makes to tighten blood vessels. Blocking the effects of endothelin allows blood vessels to relax, thereby reducing blood pressure between the heart and lungs.
4. Pros and cons of Misenbo 125
4.1. Advantages of the drug Helps slow the progression of PAH so you can live longer with the condition May help you breathe easier, exercise and walk longer distances Can be used for children 3 years and under Also available as a resolver tablet Safe to use if you have kidney problems 4.2. Cons of the Pill If you're female, you'll have to use birth control and take a monthly pregnancy test. Not all pharmacies can prescribe bosentan May affect sperm count and fertility in men May cause serious liver damage Cannot be taken with cyclosporin A or glyburide
5. Undesirable effects of drugs
Many drugs can cause side effects. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not common to everyone taking this medicine.
The following side effects have been reported by at least 1% of people taking this medicine. Many of these side effects can be controlled, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist can advise you on how to manage these side effects:
Diarrhea Fatigue Flu-like symptoms (e.g. fever, cough, sore throat, runny nose, headache) Flushing face Headache Heartburn Inflammation of the throat and nasal passages Itching Low blood pressure Congestion Nausea Skin rash Vomiting Although most of the side effects listed below do not occur often they can lead to problems serious if you don't go to the doctor.
Check with your doctor as soon as possible if any of the following side effects occur:
Abdominal pain Chest tightness Irregular heartbeat Swelling of ankles and legs Swelling in other parts of the body ( severe) Symptoms of anemia (eg, fatigue, trouble breathing) Symptoms of liver problems (eg, yellowing of the skin or eyes, nausea, vomiting, fever, abdominal pain, or unusual tiredness) often) Wheezing Stop taking the medicine and seek immediate medical attention if any of the following occur: Signs of a serious allergic reaction (e.g., swelling of the face or throat, rash or trouble breathing)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptoms that concern you while taking this medicine.
6. What are the risks and warnings for Misenbo 125?
Misenbo 125 can cause some serious health problems. If this worries you, talk to your doctor or pharmacist about other options
6.1. Liver damage Rarely, the drug can cause serious liver damage, including liver failure. You will need monthly blood tests, as it is often difficult to tell if early damage is present. Liver damage is more likely if you already have liver problems or are taking more than 125 mg of bosentan twice a day. Do not take more medicine than what your provider has prescribed for you. Never take more or double up to make up for a missed dose. If you notice severe nausea, vomiting, right-sided abdominal pain, fatigue, loss of appetite or lack of appetite, or yellowing of the skin or eyes, see your doctor for help.
6.2. Birth defects Misenbo 125 can cause serious birth defects. If you are a woman and have not gone through menopause, you will be required to use 2 types of approved birth control while taking bosentan and for one month after stopping it. You will need to provide a negative monthly pregnancy test before you can be refilled. Tell your doctor right away if you think you are pregnant or if you are unable to use your prescribed birth control method.
6.3. Heart failure The drug can cause fluid retention, especially if you have a history of heart failure. If you have any heart problems, let your provider know before you start taking the medicine. Contact your carrier right away if you notice unusual swelling in your arms or legs, rapid weight gain, or trouble breathing.
6.4. Serious lung disease Although rare, Misenbo 125 can cause a type of serious lung condition called pulmonary venous thrombosis, which can cause fluid to build up in the lungs. If your PAH symptoms get worse, become short of breath when you lie down, or if you develop a cough that doesn't go away, seek medical help right away.
6.5. Low sperm count The drug can cause problems with sperm production. This can affect your ability to have children. If you are a man and want to have children in the future, let your provider know before starting bosentan.
6.4. Low Hemoglobin (anemia) Medicines can lower your Hemoglobin levels. Hemoglobin is the protein on your red blood cells that carries oxygen. You will need regular blood tests while taking this medicine to make sure your hemoglobin stays at a healthy level. If you feel short of breath, dizzy, or more tired, let your provider know.
7. Drug interactions
Certain drugs can interfere with Misenbo 125:
Hormonal contraceptives (oral, injectable, transdermal and implanted) Simvastatin, lipid-lowering medications Diabetes medications such as glibenclamide and tolbutamide Drugs for fungal infections such as ketoconazole, itraconazole, fluconazole, and voriconazole Drugs for bacterial infections such as rifampicin Medicines to prevent organ rejection such as cyclosporine A, tacrolimus and sirolimus Medicines for rheumatoid arthritis or psoriasis, dermatitis Lopinavir + ritonavir or other ritonavir-enhanced protease inhibitors and nevirapine (used to treat HIV); Warfarin (used as an anticoagulant) Digoxin (used to treat heart rhythm disorders) Silldenafil or tadalafil (used to treat erectile dysfunction and/or pulmonary hypertension) Phenytoin, carbamazepine or phenobarbital (medicine for seizures) These medicines may be affected by Tracleer or may affect how well they work. You may need to use different amounts of medicine or take different medicines.
8. Tips for taking medicine
Take the medicine with or without food twice a day (morning and evening).
Do not stop taking your medicine unless your doctor tells you to, even if you start to feel better. Stopping the medication can cause your symptoms to return and possibly worsen your PAH.
Misenbo 125 interacts with quite a few drugs. Some of these interactions can be serious or life-threatening. Make sure your provider and pharmacist know all the medicines you are taking, including over-the-counter products, vitamins, and herbal supplements.
If you are a woman, you will need to use an approved form of birth control and provide a negative pregnancy test each month before refilling the pill. Depending on the primary birth control method you choose, you may need to use two forms of birth control.
Do not try to get pregnant while taking the pill and for at least 1 month after stopping it. Do not take Misenbo 125 if you are breastfeeding.
Drugs that reduce the number of sperm a man makes. This can affect your ability to have children. Be sure to let your provider know if there's a chance you might want to have children in the future. This may not be the best option for you.
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