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Mibeserc drug contains the active ingredient Betahistidine dihydrochloride which is indicated in the treatment of symptoms of dizziness, Meniere's syndrome, tinnitus, vestibular vertigo,... Let's learn about the uses, the notes when using Mibeserc through article below.1. Uses of the drug Mibeserc
1.1. Indications for the use of Mibeserc
Mibeserc contains the active ingredient Betahistidine, which is prepared in two strengths, Mibeserc 8mg and Mibeserc 16mg. The drug is indicated in the following cases:Dizziness, dizziness accompanied by nausea. Hearing loss, hard of hearing. Tinnitus (the sound inside the ear does not correspond to the outside). Symptomatic treatment of dizziness caused by vestibular disorders.
1.2. Pharmacodynamic
Active ingredient Betahistidine acts as an agonist on the H1 receptor, an antagonist on the H3 recetor and has no activity on the H2 receptor. The drug relaxes the precapillary sphincter, increasing blood flow to the cochlea and the entire brain. Betahistidine helps to control the capillary permeability of the inner ear, thereby helping to eliminate the accumulation of lymphatic endolymph in the inner ear. Therefore, the drug is clinically effective in treating dizziness and vertigo.1.3. Pharmacokinetics
Betahistidine is rapidly and completely absorbed after oral administration. The drug is excreted within 24 hours in the urine as 2-pyridylacetic acid, almost no unchanged Betahistidine in the urine.2. Dosage of Mibeserc
Mibeserc 16 mg drug belongs to the group of prescription drugs, so the dose used is prescribed by the treating doctor. Patients should not arbitrarily use Mibeserc without a doctor's prescription. Some recommendations on drug dosage are as follows:Adults: The recommended dose is 24 - 48mg/day divided into several doses, each time taking 1/2 - 1 tablet of Mibeserc 16mg x 3 times/day. The maintenance dose is adjusted depending on the individual patient's response. Most symptoms improve after 2 weeks of taking the drug, the effect is maximum after several months of treatment. Children: Mibeserc is not recommended for use in children under 18 years of age due to lack of data on efficacy and safety. Elderly: No dose adjustment of Mibeserc is required in the elderly. Patients with liver and kidney failure: There are no specific studies on this group of patients. The dose adjustment in patients with renal and hepatic impairment depends on the patient's condition.
3. Side effects
Mibeserc medicine can cause some of the following side effects:On the digestive system: Frequent indigestion and vomiting (dyspepsia). In addition, patients may experience symptoms of stomach pain (vomiting, stomach pain, swelling of the stomach - intestines). These adverse effects may disappear when the dose is reduced or the drug is taken after meals. On the nervous system: Headache. On the immune system: Allergies, severe hypersensitivity reactions such as swelling of the face and neck, difficulty breathing, dizziness. On skin, fatty tissue: In very rare cases, hypersensitivity reactions in the skin such as sudden swelling of the limbs, neck, rash, urticaria and itching may occur.
4. Note when using
The use of Mibeserc is contraindicated in patients with hypersensitivity to Betahistidine or to any component of the drug, patients with adrenal tumors, pheochromocytoma. Use caution when using the drug in patients with bronchial asthma, patients with a history of peptic ulcer or gastric ulcer. Caution for pregnant women: There are no studies demonstrating the effects of Betahistidine in pregnant women. Therefore, to be safe, Mibeserc should not be used in the treatment of pregnant women. Note to lactating women: There are no studies demonstrating the ability of Betahistin to be excreted in human milk. Therefore, it is necessary to weigh the benefits and risks when using this drug in this population.5. Drug interactions
The drug Mibeserc can cause some of the following interactions:MAO inhibitors, antidepressants increase the effect of Betahistidine. The structure of Betahistidine and histamine is similar, so it is possible for an interaction to affect the effectiveness of either drug. Mibeserc drug belongs to the group of prescription drugs used in the treatment of symptoms of dizziness, vertigo, tinnitus... Patients need to use the drug as prescribed by the doctor, comply with the correct course and dose to achieve high treatment efficiency.
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