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Miberic 300 has the main active ingredient Allopurinol 300 mg and other excipients with a sufficient amount of 1 tablet. The drug is effective in reducing uric acid in the blood.
1. What is Miberic?
1.1. Pharmacodynamics of Miberic: The main drug is Allopurinol, which is used to reduce blood uric acid. Uric acid is a breakdown product of purines found in food. Uric acid forms crystals in body tissues that cause gout. Increased uric acid in the blood can also cause kidney disease and kidney stones. Allopurinol is also used to prevent uric acid kidney stones and to prevent arthritis or gout attacks.
1.2. Pharmacokinetics of the drug Miberic Absorption: Allopurinol is absorbed almost completely from the gastrointestinal tract. The drug reaches its maximum concentration 4 hours after oral administration. Distribution: Miberic is less likely to bind to plasma proteins, the volume of distribution is 0.6 l/kg. Metabolism: Allopurinol is converted to the active oxypurinol. Elimination: Miberic is mainly excreted in the urine as metabolites, with a mean half-life of about 1 hour (oxypurinol 18-20 hours). 1.3. Effect of Miberic Drug Allopurinol reduces blood uric acid levels mainly by competitively inhibiting the synthesis of uric acid in the urine, thus causing less kidney stones and kidney pain.
Mechanism of action of the drug Allopurinol: The drug inhibits the enzyme xanthin oxidase - the enzyme responsible for converting the precursors hypoxanthine and xanthin to uric acid, thereby reducing blood uric acid levels.
2. What diseases does Miberic treat?
Treatment of Gout pathology, acute exacerbation. Prevention of uric acid nephropathy during cancer treatment. Stone control in individuals with increased urinary uric acid excretion.
3. Usage and therapeutic dose of Miberic
Treatment of mild gout: Treatment dose: 200 - 300 mg/day, severe disease 400 - 600 mg/day; In acute exacerbations, the minimum effective dose is 100-200 mg/day, and the maximum dose is 800 mg/day. Prevention of uric acid nephropathy during cancer treatment 600 - 800 mg/day, for 2 or 3 days. Stone control in patients with increased urinary uric acid excretion 200-300 mg/day, divided into several times. The time to take the medicine is to take it after meals.
4. Undesirable effects of the drug Miberic
Skin rash (need to stop using the drug) accompanied by fever. Nausea, diarrhea, elevated alkaline phosphatase, elevated liver enzymes, acute gout flares with vesicles.
5. Interactions of drugs Miberic
Drug Interactions Miberic may change the drug's ability to work or increase the effect of side effects. Tell your treating doctor or qualified pharmacist of all prescription and nonprescription medicines, vitamins, minerals, herbal products and other medicines prescribed by other doctors. You need to consult your doctor.
Food, alcohol or tobacco can interact with certain medications. Talk to your doctor about taking your medication with food, alcohol, and tobacco.
6. Some notes when using Miberic
Contraindications of Miberic:
Allergic to active ingredient Allopurinol. Pregnant women and lactating women. Not to be combined with Xanturic drug. Use caution when using Miberic for: Children, lactating women, people with severe renal or hepatic impairment. Storage:
Store Miberic in a cool, dry place, away from sunlight. Keep out of reach of children and household pets. Above is information about uses, dosage and usage of Miberic. Patients should carefully read the instructions for use, consult a doctor / pharmacist before using to ensure safety for health.
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