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Mibedatril 5 is manufactured and registered by HASAN - DERMAPHARM Joint Venture Co., Ltd., belongs to the group of cardiovascular drugs. Here are some information to help you understand what is Mibedatril 5?1. What is Mibedatril 5mg?
Mibedatril medicine 5mg has the main active ingredient is Imidapril hydrochloride 5mg, is made in the form of tablets, packed in boxes of 10 blisters, 5 blisters, 3 blisters, each blister has 10 tablets.2. Effects of Mibedatril 5mg
Pharmacodynamics:
Active ingredient Imidapril is an antihypertensive drug belonging to the group of Angiotensin-converting enzyme inhibitors, it acts as a prodrug, so after oral administration, it is converted to Imidaprilat. Angiotensin-converting enzyme in plasma converts inactive Angiotensin I to Angiotensin II with potent vasoconstrictor activity, stimulates the adrenal glands to secrete aldosterone and at the same time increases blood pressure. Imidaprilat has the effect of inhibiting Angiotensin-converting enzyme, preventing the conversion of Angiotensin I to Angiotensin II, helping to reduce the amount of Angiotensin II in plasma, reducing vasoconstrictor effects to help lower blood pressure and reduce blood pressure. decreased aldosterone secretion. In addition to the above mechanism, ACE also has the function of breaking down Bradykinin into inactive metabolites, so inhibition of ACE also leads to increased activity of circulating and local kallikrein - kinin systems. Peripheral vasodilator effects through activation of the prostaglandin system. Peripheral vasodilating factors via the bradykinin beta 2 receptor on endothelial cells are indirectly produced by Imidapril. With the above two mechanisms of action, the active ingredient Imidapril reduces blood pressure by reducing systemic vascular resistance but does not increase heart rate due to compensatory reflexes. Pharmacokinetics:
Absorption: After oral administration of Mibedatril 5 the drug is rapidly but incompletely absorbed, the absorption of the drug is reduced in the presence of food, the oral bioavailability of Mibedatril 5 is only about 70%, Peak plasma concentrations of Imidapril are reached 2 hours after dosing. Distribution: The substances are moderately active with plasma protein binding, 85% for Imidapril and 53% for the imidaprilat metabolite, respectively. Metabolism: Through hydrolysis of the ethyl ester, forming the metabolite Imidaprilat, so Imidapril is rapidly metabolized in the liver. Approximately 7 hours after dosing, the concentration of imidaprilat in the plasma peaks and the absolute bioavailability is about 42%. Elimination: The elimination half-life is about 2 hours, and the concentration of Imidapril decreases in a phase, with a biphasic decrease, 7 to 9 hours is the half-life of the initial and terminal phases lasting more than 24 hours. Approximately 40% of the dose is excreted in the urine, with the remainder being excreted in the feces. Approximately 5 days after the first dose of Imidapril, upon repeated dosing, steady-state concentrations of Imidapril are reached.
3. Indications and contraindications to the drug Mibedatril 5
Mibedatril 5mg is indicated for the treatment of:
Idiopathic hypertension in adults; Hypertension caused by renal parenchyma. Mibedatril 5 should not be used in the following subjects:
Patients with a history of hypersensitivity to the active ingredient Imidapril hydrochloride, drug classes of angiotensin-converting enzyme inhibitors or hypersensitivity to any of the remaining components of the drug. medicine. Patients with a history of taking an ACE inhibitor have angioedema, angioedema idiosyncratic or genetic factors. Mibedatril 5 should not be used in pregnant women during the second and third trimesters of pregnancy. Do not use in subjects with severe renal impairment with or without hemodialysis. Patients who are being treated with Dextran cellulose sulfate to lower LDL should not receive Mibedatril 5. Mibedatril 5 should not be used in children and nursing mothers.
4. How to use, dosage of Mibedatril 5mg
How to use:
Mibedatril 5 is used orally, should fix the time to use the drug every day, it is best to take it about 15 minutes before meals. The first 5 doses of Mibedatril should be administered at bedtime, because in some patients Imidapril may cause severe hypotension. Dosage of Mibedatril 5 is divided based on age, physical condition and medical condition that the patient is suffering from, some suggested doses are as follows, but it is best that the patient still needs to follow the indicated dose of the patient. Doctor:
In adults: The starting dose should be 1 tablet of 5mg once a day, when treated for at least 3 weeks but still not controlled blood pressure can increase the dose to 10mg/day (the usual dose). most effective daily). In some patients, up to 20 mg/day (maximum recommended dose) should be considered, adding a diuretic to the patient should be considered. Elderly (65 years and older): The starting dose should be 2.5 mg once daily, the maximum recommended dose is 10 mg once daily, the dose may be adjusted according to response. blood pressure response of the patient. In patients with renal impairment: The dose of Mibedatril 5 is based on the patient's glomerular filtration rate, if there is suspicion of kidney damage, it is necessary to check renal function before starting treatment. Used only for glomerular filtration rate of 30-80 ml/min, the starting dose should be 2.5 mg/day. Do not use Mibedatril 5 for glomerular filtration rate less than 30 ml/min. In patients with hepatic impairment: The recommended starting dose is 2.5 mg once daily, caution should be exercised in the indications for therapy. Do not use Mibedatril 5 in children. For patients, especially after taking the first dose, who are prone to hypotension, it is necessary to treat electrolyte and water deficiencies, in 2 to 3 days before using Mibedatril 5 all diuretics being used must be stopped. If not used, only the starting dose of 2.5 mg/day should be used. Close monitoring is required in patients at risk for hypotension, heart failure, angina or cerebrovascular disease.
5. Undesirable effects of the drug Mibedatril 5
When using Mibedatril 5, patients may experience some side effects such as:
Common side effects when using Mibedatril 5 such as dry cough, nausea, drowsiness, fatigue, dizziness, headache; Less common side effects include: cerebrovascular disorders, paresthesia, syncope, palpitations, gastrointestinal disturbances, epigastric pain, vomiting, pruritus, skin rash, bronchitis, rhinitis, infection upper respiratory tract infection, viral infection, edema, extremity pain, chest pain, increased serum creatinine/eosinophilia/gamma-GT/serum potassium/ALT/serum urea, decreased red blood cells/platelets / hemoglobin; Rare side effects include: anemia, increased AST/alkaline phosphatase, decreased serum albumin/serum protein/leukocytes, impaired renal function. It is recommended that patients experiencing any unwanted effects during the use of Mibedatril 5 need to stop using the drug and notify the doctor for timely treatment.
6. Drug interactions
Careful monitoring is required when patients receiving Mibedatril 5 concomitantly with beta-blockers and calcium channel blockers because of the potential for increased hypotensive effect. When taking Mibedatril 5 with diuretics, it can cause severe hypotension or cause renal failure, hypokalemia. Use of NSAIDs or Epoetin may increase blood pressure, reducing the antihypertensive effect of Mibedatril 5. Mibedatril 5mg drug increases the concentration of lithium in the blood leading to lithium toxicity when used with this medicine. Concomitant use of potassium supplements or potassium-sparing diuretics with Mibedatril 5 increases serum potassium. Above is all information about Mibedatril 5 drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Mibedatril 5 treatment at home because there may be unwanted side effects.
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