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Mezathion is a diuretic in the form of tablets, with a competitive potassium-sparing diuretic effect on Aldosterol, along with the effect of lowering blood pressure.
1. Indications and contraindications Mezathion
Mezathion medicine 25mg containing the active ingredient Spironolacton 25mg is indicated for the treatment of the following cases:
Patients with edema such as idiopathic edema, edema due to cirrhosis, nephrotic syndrome, congestive heart failure due to excessive aldosterone. Mezathion 25 is prescribed in combination with other diuretics. Patients with hypertension are used with other diuretics or antihypertensive drugs will be more effective. Patients with congestive heart failure use Mezathion at low doses, in combination with converting enzyme inhibitors. In patients with primary hyperaldosteronism, short-term preoperative or long-term treatment for patients with low-aldosteronism but no surgery or idiopathic hyperaldosteronism or adrenal hyperplasia. In addition, Mezathion is contraindicated in cases of hypersensitivity to the drug's ingredients as follows:
Patients with severe renal failure, along with anuria, hyperkalemia, hyponatremia, acute renal failure, .. have serum creatinine or blood nitrogen levels 2 times higher than normal Patients with liver dysfunction
2. Dosage and how to use Mezathion
Patients can refer to the following dose of Mezathion. However, to achieve the maximum therapeutic effect, patients still need to follow the specific dosage of the treating doctor:
For adults:
People with edema: The starting dose of Mezathion 25 is 100mg/day. divided into small doses or taken once. Daily dose from 25-200mg. The body that responds well can adjust the dose accordingly to get the most optimal treatment effect. Patients with congestive heart failure: Use the initial dose of 12.5-25mg/day. Physicians may increase the dose to a maximum of 50 mg/day after 8 weeks of treatment in patients with advanced heart failure and without hyperkalemia. In case of patients with hyperkalemia, the dose should be reduced to 25mg, or discontinued, depending on the actual situation of the patient. Patients with hypertension: The initial dose should be 25-50mg/day, taken once or twice daily for a minimum of 2 weeks. The specific maintenance dose depends on the individual patient. However, at present, Mezathion is rarely used to treat patients with hypertension. Patients with Aldosterone: 400mg/day for 4 days. In case the serum potassium increases during use but decreases when the drug is stopped, it is possible to diagnose primary hyperaldosteronism, the patient can take a dose of 100-400mg/day, divided into 2-4 times, short treatment before surgery. . If the patient does not need surgery, the initial dose is 400mg/day, the maintenance dose is 100-300mg/day, the lowest effective dose is recommended.
People with hypokalemia: Refer to the dose of 25-100mg / day For children:
Children using diuretics when having edema in heart failure, ascites due to cirrhosis or antihypertensive refer to the following dosage:
Newborns: oral dose of 1 -2mg/kg/day, used once or divided into 2 times. 1 month to 12 years old: 1-3mg/kg/day, 1 time or 2 divided doses. 12-18 years old: dose 50-100mg/day, taken once or divided into 2 times. The dose is adjusted after 5 days.
For the elderly, refer to the initial dose from 12.5-50mg / day, 1-2 times, if necessary, it can be gradually increased to 25-50mg every 5 days. Patients with renal insufficiency need to be adjusted specifically to their disease status.
3. Mezathion side effects
Some common side effects when patients take Mezathion are:
Fatigue, headache, somnolence, impotence Endocrine problems manifest as male breast enlargement, excessive milk flow, menstrual disorders , amenorrhea, postmenopausal bleeding in women Diarrhea, nausea, Red rash, urticaria Cramping, paresthesias Hyperkalemia, hyponatremia Some other side effects that are less common in patients are decreased platelets, granulocytes,...
If these side effects are too serious and do not improve, the patient should immediately notify the treating doctor and go to the nearest medical facility for guidance and treatment. timely mind.
4. What to do when missed dose, overdose of Mezathion?
If you forget a dose, you need to take it as soon as you remember it. However, if it is almost time for the next dose to be forgotten, the next dose can be skipped. Patients should not double the dose of Mezathion.
In case of overdose of Mezathion, patients may have confused anxiety, shortness of breath, muscle weakness. Patients need to immediately go to the nearest medical facility with the prescription they are taking to be treated promptly by gastric lavage, activated charcoal, electrolyte balance and kidney function test afterwards.
5. Notes when using Mezathion
Patients treated for heart failure using Mezathion should strictly control blood potassium levels, and at the same time avoid using potassium-containing preparations, because it can increase blood potassium. Mezathion is contraindicated in pregnancy, not safe for patients with metabolic disorders. Pregnant women using Mezathion can cause toxicity to the fetus, reduce perfusion of the placenta. However, pregnant women with heart disease can still take the drug under the supervision of a doctor. Mezathion drug can be used for mothers during breastfeeding, but should not be abused, stopping the drug can still be considered by the doctor. Mezathion can cause drowsiness, fatigue, so patients should limit, be careful while driving, or operating machinery. Mezathion 25mg is sold by prescription, needs to be stored in a cool place below 30 degrees. Patients using preservative drugs keep out of reach of children. With the above complete information about Mezathion, it is hoped that patients can use the drug safely and effectively, avoiding side effects.
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