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Mezapizin 10mg is a calcium channel blocker, used in the prevention and treatment of migraine, vestibular disorder symptoms... The following article provides you with some information about its uses and dosage. and note when using Mezapizine 10mg.
1. Effects of Mezapizine 10mg
Mezapizin 10mg has the main active ingredient is Flunarizine, is made in the form of tablets with a strength of 10mg.
Flunarizine is a difluorine derivative of cinarizin, with calcium channel blocking, antihistamine and sedative effects. The drug reduces calcium transport across cell membranes, preventing calcium overload in cells. Therefore, the drug Flunarizine dilates blood vessels, especially cerebral blood vessels. Flunarizine has no effect on myocardial contractility and conduction, does not increase heart rate, and Flunarizine has no antihypertensive effect.
2. Indications and contraindications of Mezapizine 10mg
Indications for use of Mezapizine 10mg in the following cases:
Prophylaxis and treatment of classic migraine (with warning signs such as blurred vision, glare) or common migraine (no warning signs) ). Symptoms of vestibular disorders: Dizziness, dizziness, tinnitus. Memory disorders, lack of concentration, agitation and sleep disturbances. Muscle spasticity when walking or lying down, paresthesia, cold extremities. Mezapizine 10mg is contraindicated in the following cases:
Allergy or hypersensitivity to Flunarizine or calcium channel blockers similar to Flunarizine or to any of the ingredients of Mezapizine 10mg. History of depression, Parkinson's disease, or other extrapyramidal disorder.
3. How to take Mezapizine 10mg
Mezapizine 10mg is sold with a doctor's prescription. Take Mezapizine by mouth.
3.1. Mezapizine dosage 10mg Prophylaxis of migraine:
Initial treatment:
Patients < 65 years old: The recommended dose is 10mg/time/day in the evening. Patients > 65 years: The recommended dose is 5 mg/day in the evening. Stop using Mezapizine 10mg, if:
The patient has manifestations of extrapyramidal syndrome, depression or other symptoms occur during the use of the drug. The disease did not improve after two months of treatment. Maintenance treatment:
Continue maintenance therapy with Mezapizine 10mg if the patient responds well to treatment and it is found that maintenance therapy is necessary. The maintenance dose is the same as the starting dose, but for 1 week take the drug for 5 days, then take 2 consecutive days off. If maintenance therapy is successful and Mezapizine 10mg is well tolerated, stop taking it after 6 months and resume it only if the disease recurs. Symptomatic treatment of vestibular disorders: dizziness, lightheadedness
The recommended dose in this indication is similar to the treatment of migraine. However, treatment lasts until symptoms are controlled, usually for less than 2 months. After 1 month of treatment for chronic vertigo or after 2 months of treatment for orthostatic vertigo, if symptoms of vestibular disorder do not improve, the patient should be assessed as unresponsive to Mezapizine 10 mg and treatment should be discontinued. treat. 3.2. Mezapizine overdose 10mg and management Symptoms of Mezapizine overdose: Drowsiness and asthenia may occur. There have been a few cases of acute overdose of Mezapizine (600 mg orally once), symptoms observed being agitation, somnolence, and tachycardia.
Currently, there is no specific treatment to treat an overdose of Mezapizine 10mg. Within 1 hour of an overdose, gastric lavage or activated charcoal should be used as appropriate.
3.3. Treatment of missed dose of Mezapizine 10mg Replenish the missed dose of Mezapizine 10mg as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the next scheduled dose. Do not take a double dose of Mezapizine 10mg to make up for a missed dose.
4. Undesirable effects when using Mezapizine 10mg
Some unwanted effects may be encountered when using Mezapizine 10mg:
Whole body: fatigue, drowsiness, weight gain, appetite. Psychiatric: insomnia, anxiety. Neurological: restlessness, dyskinesia, tardive movement, primary tremor, parkinsonism, extrapyramidal disorder, somnolence, tremor. Pulse: hypotension. Other possible side effects include vomiting, erythema, increased lactation. When experiencing unwanted effects of Mezapizine 10mg, it is necessary to stop using and notify the doctor for timely treatment.
5. Notes when using Mezapizine 10mg
Mezapizine 10mg should be used with caution in patients with liver disease or porphyria. Flunarizine may increase extrapyramidal symptoms, depression and flare-ups of Parkinson's syndrome, especially in susceptible patients such as the elderly. During treatment, if an increased feeling of fatigue occurs, the use of Mezapizine 10mg must be stopped. Patients should go for regular health check-ups while taking the drug, especially during maintenance treatment, to help detect extrapyramidal syndrome, depression and stop using the drug early. Ability to drive and use machines: Mezapizine 10mg may cause drowsiness, especially during the initial treatment period, caution should be exercised when driving a vehicle or operating machinery. Pregnancy: Because the safety and effectiveness of using Mezapizine 10mg in pregnant women have not been fully evaluated, Mezapizine 10mg should not be used during pregnancy. Lactation: Animal studies have shown that flunarizine is excreted in human milk at concentrations higher than those in plasma. There are no adequate data on the excretion of the drug in human milk, and therefore the use of flunarizine in lactating women is not recommended.
6. Drug interactions
Concomitant use of Mezapizine 10mg with drugs that stimulate liver enzymes (eg, Carbamazepine, Phenytoin) may increase the metabolism of flunarizine. Therefore, it is necessary to increase the dose of flunarizine when co-administered with these drugs. Alcohol and sedatives: increase the drowsiness side effects of Mezapizine 10mg. Mezapizine 10mg is used in the prevention and treatment of migraine, vestibular disorders symptoms such as dizziness, dizziness. The drug is prescribed dose and duration of use depending on the cause of the disease and the condition of each patient. It is best to consult your doctor before using Mezapizine 10mg.
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