What are the uses of Stugon Pharimex?

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Stugon Pharimex drug containing the active ingredient Cinnarizine is indicated in the treatment of symptoms of dizziness, lightheadedness, labyrinthine disorders, tinnitus, nystagmus, vomiting and nausea, migraine headaches... Learn about the uses, dosage and notes when using Stugon Pharimex through the article below.

1. Uses of the drug Stugon Pharimex

1.1. Indications “What is the drug Stugon Pharimex?” . Stugon Pharimex medicine contains the active ingredient Cinnarizine 25mg, which is indicated in the treatment of the following medical conditions:
Maintenance treatment for symptoms of labyrinth disorders including tinnitus, dizziness, dizziness, sadness vomiting and vomiting, nystagmus; Prevention of symptoms of motion sickness; Prevention of migraine migraine; Maintenance treatment of symptoms of cerebrovascular origin such as tinnitus, dizziness, vasomotor headache, irritability and inattention disorders, lack of concentration and memory loss; Maintenance treatment of symptoms of peripheral circulation disorders including cyanosis of the extremities, Raynaud's syndrome, claudication, trophic ulcers, nutritional disorders, paresthesia, nocturnal cramps , cold head extremities. 1.2. Pharmacodynamics Active ingredient Cinnarizine has been studied in vitro and in vivo and has shown to reduce smooth muscle contractions induced by vasoactive agents (including angiotensine, histamine, nicotine, bradykinine, noradrenaline, adrenaline, BaCl2). ) or caused by KCl depolarization. Cinnarizine's specific antispasmodic activity is found in vascular smooth muscle, acting on the inotropic response of depolarized smooth muscle fibers through selective inhibition of calcium ion influx into depolarized cells, thereby reducing minimizes the presence of calcium ions required for the induction and maintenance of muscle contraction. Cinnarizine is neither toxic nor interferes with important physiological functions (circulatory function, central nervous system, respiratory function).
1.3. Pharmacokinetics Studies in laboratory rats show that cinnarizine is radiolabeled after rapid absorption and gastrointestinal system and peak concentrations after 1 hour of administration (mainly in the kidneys, liver, spleen, heart) , lungs and brain). Metabolism of the drug occurs intensively within 30 minutes of oral administration and after 32 hours of oral administration, tissue concentrations are negligible. Cinnarizine is metabolized via N-alkylation, about two-thirds of the metabolite is excreted in the feces and about one-third in the urine. Cinnarizine is almost completely eliminated from the body within 5 days of dosing.

2. Dosage of the drug Stugon Pharimex

Stugon - Pharimex is taken orally and should be taken after meals. Dosage depends on the condition and age of the patient. Specifically as follows:
Dizziness, brain circulatory disorders: Take 1 tablet/time x 3 times/day.
Peripheral circulatory disorders: Take 2-3 tablets/time x 3 times/day.
Motion sickness:
Adults: Take 1 tablet/time 30 minutes before boarding the train and repeat the dose every 6 hours; The maximum dose should not exceed 225mg/day (9 tablets/day). Because the effect of the drug on the patient depends on the dose, it is necessary to increase the dose gradually; Children under 12 years: Not recommended for use in children under 12 years of age. Symptoms of Stugon Pharimex overdose have been reported (dose range from 90 to 2250 mg/day) including somnolence to coma, stupor, hypotonia, extrapyramidal symptoms, and convulsions in children. small. In case of drug overdose, the patient should be taken to medical facilities for appropriate treatment.

3. Stugon Pharimex side effects

Stugon Pharimex medicine can cause some side effects as follows:
Common side effects: Drowsiness, nausea, weight gain, digestive disorders, increased sweating, fatigue, lichenoid keratosis . Side effects of unknown frequency: Hypersensitivity, dyskinesia, extrapyramidal disorders, parkinson's syndrome, uncontrolled tremor, jaundice due to decreased bile flow, muscle spasticity.

4. Note when using the drug Stugon Pharimex

4.1. Contraindications The use of Stugon Pharimex is contraindicated in cases where the patient is sensitive to any of its ingredients.
4.2. Note that when using Cinnarizine in particular and antihistamines in general, it can cause epigastric pain. Therefore, taking Stugon Pharimex after meals can reduce stomach irritation.
Use drugs in patients with Parkinson's disease only when the benefits outweigh the risks.
In case of skin allergy test, the patient should stop using Stugon Pharimex 4 days before to avoid the risk of false negative.
Avoid using the drug in patients with disorders of porphyrin metabolism.
There are no specific studies on the liver or kidney dysfunction effects of Stugon Pharimex. However, caution should be exercised when using the drug in patients with renal or hepatic impairment.
The drug may cause drowsiness, especially at the beginning of treatment. Therefore, caution should be exercised when the drug is used concomitantly with alcohol, tricyclic antidepressants and CNS depressants.
Stugon Pharimex contains lactose, so patients with rare hereditary problems such as glucose - galactose malabsorption, galactose intolerance, lactase enzyme deficiency should not be treated with the drug.
Stugon Pharimex medicine contains a small amount of wheat starch and gluten, so people who are allergic or intolerant to gluten should not take it.
Pregnant and lactating women: Although there is no evidence of toxicity to the fetus, the benefits and risks should be weighed when using the drug in pregnant women and breastfeeding women.

5. Stugon Pharimex drug interactions

Simultaneous use of Stugon Pharimex with central nervous system depressants (beer, alcohol...), tricyclic antidepressants may increase the sedative effect of the above drugs or increase the effect of cinnarizine .
Stugon Pharimex drug containing the active ingredient Cinnarizine is indicated in the treatment of symptoms of dizziness, lightheadedness, labyrinthine disorders, tinnitus, nystagmus, vomiting and nausea, migraine headaches.. To ensure For effective use, patients need to carefully read the instructions and consult the doctor, pharmacist for advice.
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