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Metpharm has the main ingredient Metformin Hydrochloride 850mg. It is used in the treatment of type 2 diabetes, when diet and exercise are not effective in controlling appropriate blood glucose levels. Learn how to use Metpharm in the article below.1. What is Metpharm?
Metpharm medicine has the main ingredient Metformin Hydrochloride 850mg. Metformin Hydrochloride is a biguanide hypoglycemic agent used in the treatment of non-insulin dependent diabetes mellitus. Metformin Hydrochloride does not stimulate insulin secretion but is necessary for existing insulin to exert its hypoglycemic effect. Possible mechanisms of action include decreased glucose absorption from the gastrointestinal tract, increased insulin sensitivity and increased intracellular glucose utilization, and inhibition of hepatic gluconeogenesis.
2. Indications of Metpharm
Metpharm is used in the treatment of type 2 diabetes, when diet and exercise are not effective in controlling appropriate blood glucose levels.
Adults: Metformin 850mg film coated tablets can be used as monotherapy or in combination with other oral antidiabetic agents or with insulin. Children from 10 years of age and adolescents, Metformin 850 mg film-coated tablets are used as monotherapy or in combination with insulin. A reduction in diabetes complications is evident in adult patients with type 2 diabetes and obesity who are treated with metformin as first-line therapy after diet failure.
3. Dosage of Metpharm
Metpharm is recommended to be used with a starting dose of 1 tablet (850mg)/day, taken once at breakfast, gradually increasing the dose by 1 tablet/day, increasing once a week, up to 3 tablets/day. 2550mg/day).
4. Contraindications of Metpharm
Metpharm is contraindicated for people:
Diabetic ketoacidosis, diabetic pre-coma. Hypersensitivity to Metformin Hydrochloride or any of its ingredients. People with kidney failure or abnormal kidney function. Acute diseases that may alter renal function include hydronephrosis, severe infections, shock, and intravenous administration of iodinated contrast agents. Acute condition of chronic diseases that can cause tissue hypoxia such as: Heart or respiratory failure, recent myocardial infarction and shock. Liver failure, acute alcohol poisoning and alcoholism. Pregnant and lactating women.
5. Be careful when using Metpharm
Lactic acidosis, although rare but dangerous (high mortality in cases without prompt treatment), metabolic complications may arise from the accumulation of metformin. Reported cases of lactic acidosis in patients receiving metformin have occurred mainly in patients with diabetes mellitus with severe renal impairment. The incidence of lactic acidosis can and will be reduced by an assessment of other associated risk factors such as poor control of diabetes mellitus, ketosis, prolonged fasting, excessive alcohol consumption, and hepatic insufficiency. and any disease related to hypoxia. If metabolic acidosis is suspected, metformin should be discontinued immediately and the patient hospitalized. Renal Function: Since Metformin is eliminated by the kidneys, serum creatinine should be determined prior to initiating therapy and regularly thereafter at least annually in patients with at least normal renal function. 2-4 times a year for patients with serum creatinine above the upper limit of normal and the elderly. Use of iodinated contrast media: Intravenous administration of iodinated contrast media in X-ray studies may lead to renal failure. Metformin should be discontinued before or during the test and not repeated until 48 hours later, and only after renal function has been reassessed and found to be normal. Metformin should not be used in children. Because of the potential for impaired renal function in elderly patients, the dose of metformin should be adjusted based on renal function. Pregnancy and breast-feeding: To date, there are no relevant epidemiological data. Insulin is often preferred in the treatment of diabetes in pregnant women to reduce the risk of fetal malformations associated with abnormal blood glucose levels. Metformin should not be used by pregnant women. Studies have shown that Metformin is excreted in the milk of rats. Similar data are not significant in humans and a decision should be made whether to discontinue nursing or to discontinue metformin, taking into account the importance of the drug to the mother. Effects on ability to drive and use machines: No effect.
6. Undesirable effects of Metpharm
Metpharm causes adverse effects on the gastrointestinal system including: Nausea, vomiting, diarrhea, abdominal pain, appetite are very common: They appear almost frequently during the initial period of treatment and resolve spontaneously. normal in most cases. To prevent gastrointestinal symptoms, Metformin is recommended to be taken 2-3 times daily with or after meals.
The absorption of various substances including vitamin B12 may be reduced. The patient may have a metallic taste and weight loss.
If experiencing these symptoms, the patient should stop using Metpharm and notify the doctor for appropriate treatment.
Above is all information about Metpharm, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Metpharm medicine at home because there may be unwanted side effects.
