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Hindgra 100mg is manufactured by Axon Drugs Private Ltd, India. Hindgra 100 has the main ingredient sildenafil, commonly indicated in the treatment of erectile dysfunction in men.
1. What is Hindgra 100?
Hindgra 100 is a prescription drug belonging to the group of hormones, hormones. Hindgra 100mg tablet contains sildenafil as the active ingredient.
Dosage form: Blue, biconvex, biconvex film-coated tablets. Each tablet contains 100mg of sildenafil (as sildenafil citrate) and other excipients.
Packing form: Blister of 4 tablets, each box has 1 blister.
2. What does Hindgra 100 do?
Pharmacodynamics: Sildenafil is a selective inhibitor of phosphodiesterase group 5, used in the treatment of erectile dysfunction. Inhibition of group 5 phosphodiesterase results in decreased metabolism of cyclic guanosin monophosphate, which is primarily responsible for the regulation of nitric oxide vasodilation, resulting in local vasodilation of smooth muscle and increased capacity response to sexual stimuli.Effects on the penis: Several studies have shown that sildenafil has a significant effect on improving erections, as assessed through objective criteria such as hardness and duration of erection. This process was assessed after 1 hour of dosing.
Effects on blood pressure: In healthy volunteers, oral administration of 100 mg of sildenafil reduced blood pressure. This effect is pronounced 1-2 hours after dosing and is independent of dose and plasma concentration. Patients experience more hypotension when co-administered with drugs containing nitrates.
Effects on vision: Sildenafil adversely affects the ability to distinguish colors (green/blue) when used in doses of 100mg and 200mg.
Pharmacokinetics:
Absorption: Sildenafil is rapidly absorbed after oral administration, peak plasma concentrations in 30-120 minutes. Distribution: Sildenafil is widely distributed throughout the body tissues. The plasma protein binding is 96% and is independent of drug concentration. Metabolism: Sildenafil is metabolized to the N-demethylated form by CYP3A4 and CYP2C9. Elimination: Sildenafil is eliminated mainly via the faeces (80%) and urine (13%).
3. Indications and contraindications of Hindgra 100
Hindgra 100mg is indicated for the treatment of erectile dysfunction in men, i.e. the inability to complete or maintain an erection sufficient to perform sexual acts in adult men. Hindgra 100 works when accompanied by sexual stimulation.Contraindications: Absolutely do not use Hindgra 100mg in the following cases:
Allergy to any ingredient of Hindgra 100; Women, pregnant women; Teenagers under 18 years old; The patient is taking other organic nitrates; Severe liver failure; Lower blood pressure; Myocardial infarction, stroke ; Hereditary degenerative retinal disorders such as retinitis pigmentosa.
4. Dosage and how to use Hindgra 100mg
Hindgra 100 is a prescription drug, so you are only allowed to use it with the permission of your doctor and must strictly follow the instructions. You must not arbitrarily change the dose of the drug as well as the route of administration, or give the medicine to others to use when they see that they have the same symptoms as you.
Dosage:
Adults: 50mg/time. Dosage can be up to 100mg or reduced to 25mg, up to a maximum of 100mg. Use only once a day. Elderly: Start with 25mg. It can then be increased to 50mg or 100mg at subsequent doses. Patients with mild to moderate renal impairment: Use as normal adults. Severe renal impairment: Start with 25mg. It can then be increased to 50mg or 100mg depending on efficacy and tolerability. How to use: Take the drug 1 hour before sexual activity. The drug is effective in the presence of sexual stimulation.
What to do in case of an overdose of Hindgra 100mg?
Overdose increases the risk of occurrence and severity of side effects (headache, dizziness, flushing, gastrointestinal upset, ...). You need to immediately go to the nearest medical examination and treatment facility for timely emergency treatment, you need to bring all the medicines you have used before to facilitate the diagnosis of the cause. Supportive treatment is the main treatment.
5. Undesirable effects
During the use of Hindgra 100, you may experience unwanted effects such as:
Common: Headache, dizziness, anxiety, dizziness, insomnia, fever, facial flushing, nosebleeds , nasal congestion, digestive disorders, vomiting, blurred vision, photophobia, eye pain, red eyes, green/blue indistinguishability, ... Rare: Depression, dementia, migraine, epilepsy, shock, syncope, cerebral thrombosis, cerebral hemorrhage, subarachnoid hemorrhage, hypertension, angina pectoris, cardiomyopathy, heart failure, myocardial infarction, tachycardia, asthma, pulmonary hemorrhage, stomatitis, colitis, rectal bleeding, allergy, edema, exfoliative dermatitis, cystitis, bedwetting, gout, myasthenia gravis, tendon rupture, anemia and leukopenia, ... The side effects of Hindgra 100 listed above are not exhaustive, and you may experience other symptoms. So to ensure safety when taking Hindgra 100, contact your doctor immediately when you see any unusual symptoms for timely treatment.
6. Drug interactions
Drug interactions affect the absorption, effects as well as potentially increase the side effects of Hindgra 100. So to be on the safe side, you need to tell your doctor about all the medications you're taking, including prescription, over-the-counter, herbal, and dietary supplements. Some drugs can interact with Hindgra 100 such as:
Cytochrome inhibitors such as cimetidine, ketoconazole, itraconazole, erythromycin, ritonavir, saquinavir, ... have the ability to increase the concentration of hindgra 100 in the blood plasma. Cytochrome P450 3A4 stimulators such as rifampicn have the potential to decrease Hindgra 100 plasma concentrations.
7. Preservation of drugs
Keep Hindgra 100mg in a cool, dry place, away from direct sunlight, at a temperature not exceeding 30 degrees Celsius. Keep Hindgra 100mg out of reach of children and pets. Before using, it is necessary to check the expiry date stated on the package, do not use the medicine that has expired on the package or has signs of color or nature change.
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