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Maxsetron drug is used in the treatment of hangover, vomiting caused by chemotherapy, radiation therapy, ... So how to use Maxsetron? What precautions should be taken when using this drug? Let's find out the necessary information about the drug Maxsetron through the article below.
1. Uses of the drug Maxsetron
Effects
Ondansetron is a highly selective 5-HT3 receptor antagonist. The exact mechanism of action of the drug in the control of vomiting is unknown. Chemotherapy and radiation therapy can induce the vomiting reflex by activating the vagus nerve via the 5HT receptor. Ondansetron inhibits the initiation of this reflex. Activation of the vagus nerve can also cause 5HT release in the postrema region above the floor of the fourth ventricle and promote vomiting via a central mechanism. Thus, the effect of Ondansetron in the treatment of nausea caused by chemotherapy or radiotherapy may be due to antagonism of 5HT3 receptors on peripheral nerves and central nervous system.
Medicines used to prevent nausea and vomiting during cancer treatment with chemotherapy and vomiting or nausea after surgery.
The drug is not a dopamine receptor blocker, so there are no extrapyramidal side effects.
Indications
Nausea and vomiting due to chemotherapy and radiation therapy . Prophylaxis of nausea and vomiting after surgery. Treatment of nausea and vomiting after surgery Dosage - how to use:
Nausea and vomiting due to chemotherapy and radiotherapy Adults:
Mild vomiting: 8mg IM or IV slowly before chemotherapy, then 8mg orally after 12 hours; Strong vomiting: 1 dose of 8mg injected before chemotherapy, then 2 doses of 8mg intravenously 2-4 hours apart, or continuous infusion of 1mg/hour for up to 24 hours; Prophylaxis of delayed vomiting: 8mg x 2 times/day x 5 days after 1 course of treatment. Children: 5 mg/m2 before chemotherapy, 12 hours after taking 4mg x 2 times/day x 5 days.
Prophylaxis of nausea and vomiting after surgery. Adults: 16mg orally 1 hour before anesthesia or slow IV injection 4mg at anesthesia;
Children > 2 years old: slow IV injection 0.1mg/kg, up to 4mg before or after anesthesia.
Treatment of nausea and vomiting after surgery: Adults: slow IV injection 4mg;
Children > 2 years: slow IV injection 0.1mg/kg, maximum 4mg. Hepatic impairment: up to 8mg/day.
Overdose, missed dose and treatment
Overdose: Symptoms of drug overdose are quite similar to symptoms of side effects. In addition, patients may experience liver and kidney toxicity. Patients should be closely monitored for skin, facial expressions, blood pressure and precautions because this dangerous condition can progress very quickly. Ideally, the patient's condition should be informed to the treating doctor for timely treatment
Missed dose: avoid missed dose; If a dose is missed, the patient should skip the missed dose and do not overlap the dose with the next dose.
Do not skip doses more than 2 times in a row.
2. Notes when using the drug Maxsetron
Contraindications
Do not use Maxsetron 2 mg/ml for people with a history of hypersensitivity to any of the ingredients in the drug.
Attention and caution
Use with caution in patients with impaired liver function, the total daily dose should not exceed 8mg. Consider treatment in patients with suspected bowel obstruction. Do not use the drug for women who are pregnant in the first 3 months of pregnancy or breast-feeding. Breastfeeding should be discontinued while using the drug. Careful monitoring is required in patients with cardiovascular disease, use of antiarrhythmic drugs, beta-blockers. During the course of treatment, patients need to adhere to the indications, not arbitrarily increase or decrease the amount of medication taken to be effective. It is necessary to consult with the treating physician before deciding to discontinue drug treatment. Other notes:
With drugs that have expired or appear strange on the drug such as mold, drug color change, watery, should not continue to use. Avoid storing the medicine in places with direct sunlight or high humidity. Do not leave the medicine near the place where children play, to avoid the case that children can play and accidentally drink.
3. Maxsetron side effects
Common side effects: Increased body temperature, headache, drowsiness, defecation or defecation Uncommon side effects: dizziness, dizziness, dry mouth, abdominal cramps. Other side effects: anaphylaxis, arrhythmia, low blood pressure, electrolyte disturbances, hiccups. In case patients experience side effects such as itching, redness or any other symptoms suspected to be due to taking the drug, they should consult their doctor or pharmacist for advice.
4. Drug interactions
When used with other drugs
Inducers of CYP3A4 and CYP2D6 such as rifampicin, tobutamide, barbiturates or inhibitors of CYP3A4 and CYP2D6 such as MAOIs, chloramphenicol, cimetidine may alter blood concentrations.
The drug reduces the analgesic effect of tramadol when taken together.
Anthracyclines or other cardiotoxic drugs when taken together can increase the risk of arrhythmias
It is important for the patient to list the medications or supplements they are taking at this time to the doctor can know and advise to avoid unwanted drug interactions.
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