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Maxigra medicine has the main active ingredient sildenafil which is made in the form of film-coated tablets. Maxigra is indicated in the treatment of erectile dysfunction in men, or possibly sexual arousal. However, before using the drug, the patient needs to carefully study the information and adhere to the treatment.
1. Mechanism of action of the drug Maxigra
Maxigra is used by mouth to treat erectile dysfunction. In its natural state, during sexual stimulation, Maxigra restores erectile function by increasing blood flow to the penis. The physiological mechanism of erection will involve the release of nitrous oxide in the corpus cavernosum during sexual arousal. Nitric oxide then activates the enzyme guanylate cyclase to increase the concentration of cyclic guanosine monophosphate (cGMP), thereby rendering the vascular smooth muscle of the corpus cavernosum.
Maxigra potently and selectively inhibits the phosphodiester responsible for the breakdown of cGMP. Not only that, the compound sildenafil in Maxigra also has an effect on erection in the peripheral position.
2. Indications and contraindications to using Maxigra
What does Maxigra do? Maxigra is indicated for the treatment of erectile dysfunction. In the presence of sexual stimulants, Maxigra can increase blood flow to the penis to help restore erectile function.
Maxigra drug also acts on erection in the peripheral position, thereby increasing the ability to erect penile. However, the drug Maxigra does not relax directly on the corpus cavernosum, but enhances the effect on this tissue to help blood flow smoothly. The drug Maxigra has the desired pharmacological effect only in the presence of sexual stimulation. However, Maxigra is also contraindicated for some people who are allergic or sensitive to the ingredients of the drug, who are using nitric oxide or nitrate in any form. Men should not be sexually active in people with severe cardiovascular disorders with unstable angina or severe heart failure. Cases of vision loss, severe liver failure, hypotension or a history of stroke, myocardial infarction, degenerative retinal disorders...
3. Dosage of Maxigra
Maxigra should be taken whole with a sufficient amount of water. The drug should not be crushed, chewed or broken as it may reduce the bioavailability of Maxigra.
Maxigra is recommended to be taken at a dose of 50mg approximately 1 hour before sexual intercourse. However, depending on the tolerability and effect of the drug in each person, the dose can be increased to 100 mg or reduced to 25 mg. But the maximum dose used is 100mg. The maximum number of times of use of the drug in a day is once.
For some special subjects, it is necessary to adjust the dose of Maxigra to suit:
Patients with renal failure, the dose applied to this object may be similar to that of normal adults, but these patients are at a different level. mild to moderate renal impairment with creatinine clearance between 30 and 80 ml/min. However, in severe renal impairment, a dose of 25 mg may be considered, as sildenafil clearance is reduced in this patient. However, depending on the efficacy and tolerability of Maxigra, the dose can be increased in steps of 50 mg or then increased to 100 mg if absolutely necessary.
For patients with hepatic impairment, a 25 mg dose of Kamagra should be considered. Based on results and tolerability, the drug can be increased in steps of 50 mg or 100 mg if necessary.
Note: The above recommended therapeutic dose for Maxigra is for reference only. Therefore, before using Maxigra, patients need to be prescribed by a doctor.
4. Management of missed dose and overdose of Maxigra
If you miss a dose of Maxigra, use the missed dose as soon as you remember. However, if the interval between the missed dose of Maxigra and the next dose is too close, skip the missed dose. Patients should not use a double dose of Maxigra, because it can cause an overdose. To overcome the situation of missing a dose of Maxigra, you can set an alarm or ask a loved one to remind you.
In case of accidentally using Maxigra drug in excess of prescribed and showing some unwanted signs, it is necessary to take the patient to the emergency room immediately. However, family members can apply some preliminary treatment measures when Maxigra poisoning such as gastric lavage, vomiting. Next, take the patient to a medical facility to treat the symptoms.
5. Unwanted side effects when using Maxigra
Maxigra can cause some unwanted side effects during treatment. However, with each case Maxigra can occur in varying degrees from mild to severe.
Some common side effects caused by Maxigra include: headache, visual disturbances, distorted color vision, dizziness, flushing, indigestion, nasal congestion... These side effects may occur at the start of treatment or after increasing the dose of Maxigra. Usually, side effects from Maxigra can be transient or subside over time.
However, in some cases Maxigra can cause serious unwanted side effects with rare reactions. These reactions may appear within minutes of taking Maxigra or longer within a few days. When serious side effects appear such as: increased heart rate, fatigue, blood in urine, chest pain, muscles, extremities, dry mouth, gastroesophageal reflux, nosebleeds, deafness, sudden cardiac arrest, prolonged erection ... the patient should stop using Maxigra and should be taken to medical assistance immediately.
Some notes during the use of Maxigra drugs
Maxigra drugs may change the ability to work as well as increase the effect of side effects. Therefore, to avoid this situation, the patient should provide the doctor with a list of previously used drugs including prescription drugs, over-the-counter drugs, herbs... Maxigra drugs interact with drugs: if used Concomitant use of Maxigra with drugs that inhibit CYP3A4 reduces the elimination of the compound Saldenafil. Maxigra should not be combined with ritonavir, as they may increase the plasma concentration of Saldenafil. Maxigra can cause dizziness and loss of vision during use. Therefore, for those who need to be alert, awake or drive a vehicle, machinery should be cautious when using Maxigra. Above is the important information about the drug Maxigra, patients should carefully read the instructions for use and use according to the dose prescribed by the doctor to achieve the best effect.
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