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Tadachem belongs to the group of muscle relaxants and muscle tone boosters containing Tadalafil, a film-coated tablet, in a box containing 2 blisters, each blister contains 2 tablets. The drug is used in the treatment of erectile dysfunction in men.1. What is Tadachem?
Tadachem contains the drug Tadalafil, in tablet form, used for men with erectile dysfunction. Drugs made in India, registered by Viet An Pharmaceutical Joint Stock Company. The clinical effectiveness of Tadachem is due to the effect of the main drug Tadachem contained in the drug.
Penile erection is caused by increased blood volume from dilation of the penile arteries and in the corpus cavernosum. This response is mediated by the release of the bioregulator nitric oxide at nerve terminals and epithelial cells, which in turn stimulates the synthesis of cyclic GMP in smooth muscle cells. Loop GMP relaxes smooth muscle and increases blood flow to the corpus cavernosum. The drug effectively inhibits phosphodiesterase type 5 (called PDE5), increasing the number of cyclic GMPs, thereby improving erectile function. Provided that sexual stimulation is required to initiate the release of nitric oxide, Tadachem is ineffective in the absence of accompanying sexual stimulation. After oral administration, Tadachem reaches maximum plasma concentrations within 30 minutes. The rate of absorption and extent of drug absorption are not affected by food. The mean volume of distribution of the drug is 63 L. At therapeutic concentrations, 94% of the drug Tadalafil is bound to plasma proteins. The drug is extensively metabolised by CYP3A4 to the catechol product, which is further methylated and glucuronidated. The metabolites of Tadalafil are inactive. The major circulating metabolite is methylcatechol glucuronide. The mean clearance of the drug is 2.5 L/hour, the mean half-life is about 17.5 hours. Tadachem is mainly excreted in feces, accounting for about 61% and urine about 36% as metabolites.
2. Indications and contraindications of Tadachem
Indications for use of Tadachem:
Tadachem is indicated for the treatment of erectile dysfunction in men. Do not use Tadachem in the following cases:
Contraindicated to use Tadachem for women. Do not use the drug concurrently with any drug or product containing organic nitrate compounds. Hypersensitivity: Do not use this medicine in patients who are allergic to Tadalafil or any of its excipients. Patients with cardiac disease including myocardial infarction, severe heart failure, or unstable angina or arrhythmia. Blood pressure problems, including low blood pressure, uncontrolled high blood pressure. Men with cerebrovascular accident.
3. Dosage and how to use Tadachem
How to use: Tadachem is used orally. Patients who use the drug before sexual activity can take it at any time of the day because food does not reduce the absorption of the drug.
Note: With aphrodisiac activity, Tadachem will be effective.
Dosage:
Starting dose: Usually 10mg oral dose. Dosage may be increased to 20 mg/time or reduced to 5 mg depending on individual tolerability and efficacy. The maximum dose is once a day. Tadachem is effective up to 36 hours after taking it. Care should be taken to use the right dose of the drug. Renal Impairment: No dose adjustment of Tadachem is necessary in patients with mild renal impairment. Patients with moderate renal impairment should be started at 5 mg and with a maximum dose of 10 mg every 48 hours. In patients with severe renal impairment, the maximum dose is 5mg. Hepatic impairment: Patients with mild and moderate hepatic impairment should not exceed 10mg a day. If liver failure is severe, the patient should not use this drug. Drug overdose : Healthy people use the drug at a single dose of 500mg or multiple times with a total dose of 100mg, the rate of unwanted effects is the same as when taking a low dose.
In case of drug overdose, the patient should apply symptomatic and supportive measures.
4. Undesirable effects of Tadachem
Unwanted effects that may occur when using Tadachem include: Headache, signs of digestive disorders, muscle pain, back pain, pain in limbs, nasal congestion, facial flushing, pain angina, low blood pressure, myocardial infarction, tachycardia, palpitations.
Inform the doctor if the male patient experiences unwanted effects when using the drug.
5. Notes in the process of taking Tadachem
When using Tadachem, patients should pay attention to the following issues:
Drug interactions: When using Tadachem, there may be interactions with drugs that male patients are using such as: cytochrome P450 inhibitors. including Ritonavir, Ketoconazole, Itraconazole, Erythromycin increase the concentration of Tadalafil. Drugs that induce cytochrome P450, eg Carbamazepine, Rifampicin, Phenytoin, Phenobarbital reduce drug concentrations. Men with cardiovascular disease: The doctor should consider the patient's cardiovascular condition before using this medicine. Men with congenital retinopathy, including retinitis pigmentosa, do not use drugs. If the patient experiences penile pain for more than 4 hours, the doctor should be informed. The safety and effectiveness of the combination of Tadachem and other erectile dysfunction drugs has not been evaluated. Tadachem should not be given to men under 18 years of age. The drug is for men, so pregnant women, lactating women should not use Tadachem. This is a prescription drug under the advice and guidance of a doctor, patients absolutely do not use it on their own. Above is information about the use of Tadachem. It is effective when used in men over 18 years of age with erectile dysfunction. It is necessary to use the drug according to the instructions, only when indicated, in the right dose to limit the unintended effects of Tadachem. Please consult your doctor, pharmacist, or medical staff if you have any questions or concerns about Tadachem.
