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Majegra 100 contains the active ingredient Sildenafil which is indicated in the treatment of erectile dysfunction, impotence, premature ejaculation. Let's learn about the uses and notes when using Majegra 100 through the article below.
1. Uses of Majegra 100
Majegra 100 contains the active ingredient Sildenafil 100mg in the form of film-coated tablets. Active ingredient Sildenafil selectively inhibits the enzyme PDE5, promotes the metabolism of GMPc (the substance that affects the erection of the penis) increases accumulation and prolongs the lifetime of GMPc. The concentration of GMPc affects blood flow to the penis, so GMPc plays a major role in getting an erection. Under the blood stasis effect of GMPc helps to erect the penis and prolong the sex time.
Majegra 100 is indicated in the following cases:
Men over 18 years of age with erectile dysfunction, impotence, premature ejaculation, decreased or loss of pleasure in sexual intercourse; People need to increase the time of sex.
2. Dosage of the drug Majegra
Majegra is taken by mouth, patients should take it 30 minutes - 1 hour before sex. Some recommendations on the dosage of Majegra are as follows:
The recommended dose in most patients is 50mg, taken 30 minutes - 1 hour before sex. The maximum dose should not exceed 100mg/time/day. For patients at high risk for increased plasma concentration of Sildenafil such as patients with liver failure, people over 65 years of age, patients with severe renal impairment, patients being treated with cytochrome P450 3A4 inhibitors such as Ketoconazole, Erythromycin, etc. Itraconazole... Use 25mg/time/day.
3. Side effects of the drug Majegra
Majegra can cause some unwanted effects as follows:
Facial flushing, headache, nasal congestion, esophageal obstruction; Visual disturbances such as sensitivity to light, blurred vision, temporary loss of distinction between blue and green, chest pain; Rare side effects: Erection and penile pain lasting more than 6 hours after taking the drug. Patients should stop using the drug and notify the treating doctor in case of any unwanted effects when taking Majegra.
4. Notes when using Majegra
4.1. Contraindications Contraindicated to use Majegra in the following cases:
People with severe cardiovascular disease, history of stroke, cardiac arrest, uncontrolled high or low blood pressure; Patients with hereditary degenerative retinal disorders, severe liver disease, pregnant or lactating women, children under 18 years old; Patients with hypersensitivity to Sildenafil or any ingredient of Majegra. 4.2. Precautions when using the drug Caution when using Majegra in the following subjects:
Patients with anemia (abnormalities in red blood cells), leukemia, people with myeloma (bone marrow cancer) or any any other change in the penis; The efficacy and safety of Sildenafil have not been established in patients with blood disorders and in patients with peptic ulcer disease, so caution should be exercised in its use in these patients; Majegra should be used with caution in patients who have had a stroke, myocardial infarction, or life-threatening arrhythmia in the last 6 months; For drivers, operating machines: Side effects such as headache, dizziness, blurred vision have been reported during treatment with Sildenafil, so patients driving or operating machinery should be cautious when using it. Use Majegra. Store Majegra at room temperature, away from sunlight and high humidity.
5. Drug interactions
Active ingredient Sildenafil is metabolised in the liver by CYP3A4 enzyme, so concurrent use with CYP3A4 inhibitors such as Erythromycin, Ketoconazole, Cimetidine, Itraconazole... The antihypertensive effect of Amlodipine is increased with concomitant use. time with Sildenafil. Sildenafil's active metabolite, N - demethyl sildenafil, has a 102% increase in plasma concentration when co-administered with a non-selective beta-blocker and a 62% increase in co-administration with a loop or diuretic. keep potassium. Drugs that induce liver enzymes decrease the concentration and increase the clearance of Majegra. The dose of Sildenafil should be reduced when used in combination with d-blocker drugs (dosazoxin, terazosin...) or a-blocker drugs. The active ingredient Sildenafil has a vasodilator effect, so it may increase the antihypertensive effect when used concurrently with antihypertensive drugs. Bosentan induces CYP3A4 and CYP2C9 enzymes, resulting in increased clearance and decreased exposure to Sildenafil. Carbamazepine, Barbiturates, Phenytoin, Nevirapine, Efavirenz... are strong inducers of CYP3A4, so they change the plasma concentration of Sildenafil. Concomitant administration of Rifamycin and Majegra reduces the plasma concentration of Sildenafil. Phosphodiesterase Inhibitors: Several studies on the effects of sildenafil on certain tissues (coronary artery, cavernous body) showed that sildenafil did not significantly increase cAMP concentrations. Therefore, the hypotensive, cardiotoxic, or bleeding effects of sildenafil and phosphodiesterase inhibitors have not been well established. Drug interactions occur that reduce the therapeutic effect of Majegra, increasing the risk of unwanted effects. Therefore, patients need to inform their doctor about the medicines they are using before taking Majegra to ensure safety and effectiveness.
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