Uses of Grafil

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1. What is Grafil?

What is Grafil? 1 Grafil tablet contains 50mg of Sildenafil and other excipients. Sildenafil is the citrate salt of Sildenafil, used orally to treat erectile dysfunction. Sildenafil is a selective inhibitor of cGMP (cyclic guanosine monophosphate) - type 5 specific phosphodiesterase (PDE5). The mechanism of action of this ingredient is as follows:
The physiological mechanism of penile erection leads to the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation; Then, NO activates the enzyme guanylate cyclase, increasing the concentration of cGMP, thereby relaxing the vascular smooth muscle in the cavernous body, allowing blood flow; Sildenafil does not have a direct dilating effect on human corpus cavernosum, but it enhances the effect of NO by inhibiting PDE5. This is a substance that degrades cGMP in the corpus cavernosum; When sexual stimulation induces local release of NO, inhibition of PDE5 by Sildenafil increases cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and increased blood flow to the corpus cavernosum. Indications for use of Grafil:
Treatment of erectile dysfunction (inability to achieve or maintain an erection sufficient to satisfy sexual activity); Grafil is only effective when accompanied by sexual stimulation. Contraindications to the use of Grafil:
Patients who are allergic or sensitive to any of the ingredients in the drug; The patient is taking medications that provide nitric oxide, organic nitrates or organic nitrites; Treatment of erectile dysfunction is not recommended for people with cardiovascular disease.

2. How to take and dose of Grafil

Usage: Orally.
Dosage:
Adults: The recommended dose is 50mg (1 pill), taken about 1 hour before sex. Based on tolerability and efficacy, the dose may be increased to a maximum of 100 mg or reduced to 25 mg. The maximum dose is 100mg/time/day; Children: Do not use Grafil in children under 18 years of age; Elderly (over 65 years): Start with 25mg; Patients with severe renal impairment (creatinine clearance less than 30ml/min) or patients with liver failure: The dose of 25mg should be used; Patients taking other drugs: Ritonavir: Dosage should not exceed 25mg within 48 hours; CYP3A4 inhibitors (saquinavir, erythromycin, ketoconazole, itraconazole): It is recommended to start with 25 mg; Alpha blockers (tetrazocin, doxazocin,...): Do not use more than 25mg, the interval between taking the drugs must be more than 4 hours. Overdose: A human study with a single 800 mg dose of Sildenafil found that adverse events at this dose were similar to those of lower doses but increased in frequency. In case of overdose, standard supportive measures should be taken.
Drug abuse:
There have been cases of abuse of Grafil causing an erection lasting for more than 4 hours, and an erection for more than 6 hours. In this case, the patient should seek medical attention immediately; Sexual activity can affect heart health, especially for people with cardiovascular disease. Possible risks include myocardial infarction, arrhythmia or stroke, which are life-threatening. Therefore, people who have heart problems or have ever experienced chest pain, dizziness, ... during sexual activity should consult a doctor.

3. Side effects of the drug Grafil

When using Grafil, patients may experience some side effects of the drug. In general, side effects are usually transient, mild, or moderate. The most common condition is headache and facial flushing.
Some other side effects when taking Grafil drugs include:
Immune system: Hypersensitivity reactions (including skin rash); Cardiovascular system: Serious cardiovascular disorders including angina syndrome, myocardial infarction, transient ischemia, ventricular arrhythmias, hypertension, cerebrovascular accident, syncope, hypotension, palpitations chest, rapid pulse, nosebleed, sudden cardiac death; Digestive system: Vomiting; Eyes: Eye pain, red eyes, eyes with bleeding spots; Reproductive system: prolonged penile erection, penile painful erection. When experiencing side effects of Grafil, patients should immediately notify their doctor for advice on appropriate management measures, to limit the risk of experiencing some dangerous complications.

4. Be careful when using the drug Grafil

Before and while using Grafil, patients should note the following issues:
Be careful when using Grafil in patients with low blood pressure or high blood pressure; Grafil should be used with caution in patients with anatomical abnormalities of the penis, a pathology that can cause penile erection pain (such as leukemia, multiple myeloma, sickle cell anemia); Grafil should be used with caution in patients with serious cardiovascular disorders such as unstable angina or severe heart failure; The safety and effectiveness of the combination of Sildenafil and other erectile dysfunction drugs have not been studied. Therefore, the drug should not be combined with any other drugs; Use caution when using Grafil in patients with coagulopathy, acute peptic ulcer; Grafil should be used with caution in patients with retinitis pigmentosa with disorders of the retinal phosphodiesterase gene; Avoid eating grapefruit or drinking grapefruit juice while taking Grafil, unless authorized by your doctor; Do not use Grafil in women, pregnant women and nursing mothers; Grafil may cause dizziness and visual disturbances, so caution should be exercised when driving or operating machinery or working at height. In addition, patients should limit the use of alcoholic beverages while taking this medicine.

5. Grafil drug interactions

Some drug interactions of Grafil include:
Concomitant use of Sildenafil with CYP3A4 inhibitors such as cimetidine, erythromycin, saquinavir, ketoconazole, itraconazole will reduce the clearance of Sildenafil; Sildenafil has the potential to potentiate the hypotensive effects of acute and chronic nitrates. Therefore, Sildenafil must not be used concurrently with substances containing nitric oxide, organic nitrates or organic nitrites in any form (whether regular or intermittent); The use of Sildenafil in patients receiving alpha-blocker therapy may cause systemic hypotension in some patients. When prescribed by a doctor to use Grafil, the patient should follow all instructions. At the same time, patients should change their diet, lifestyle and exercise, keep themselves a comfortable mind, and persevere in treatment to improve their health in general and their physiological ability in particular.
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