Uses of magdivix

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1. Uses of the drug Magdivix

Magdivix medicine has the main active ingredient: Magnesium lactate dihydrate with the content of 470mg and Pyridoxine hydrochloride (Vitamin B6) with the content of 5mg. Magdivix is ​​available as a film-coated tablet. Vitamin B6: Vitamin B6 exists in three forms: pyridoxal, pyridoxamine, pyridoxine, when these three forms enter the body, they are converted into pyridoxal phosphate and partly into pyridoxamine phosphate. These two active ingredients act as coenzymes in glucose, protein and lipid metabolism. Pyridoxine participates in the synthesis of gamma-aminobutyric acid in the central nervous system and participates in the synthesis of hemoglobin.
The need in children is 0.3-2mg/day, in adults is about 0.6-2mg/day, pregnant and lactating women 2.1-2.2mg/day. Vitamin B6 deficiency is rare in humans, but can occur in patients with congenital metabolic, malabsorption or drug-induced disorders. Patients on isoniazid treatment or women taking oral contraceptives, the daily vitamin B6 requirements increase more than usual. Drugs acting as pyridoxine antagonists: cycloserin, isoniazid, hydralazine, penicilamine and other carbonyl compounds can combine with vitamin B6 and inhibit the coenzyme function of this vitamin. Pyridoxine is used in the treatment of convulsions or coma caused by isoniazid poisoning. This symptom is thought to be due to decreased levels of GABA in the central nervous system, because isoniazid inhibits the action of pyridoxal-5-phosphate in the brain.
Pyridoxine is used as an adjunctive drug in the treatment of acute poisoning by fungi of the genus Giromitra to treat the neurological effects (such as convulsions, coma) of methylhydrazine, which is hydrolysed from the toxin gyrometrin found in mushrooms. this.
Magnesium lactate dihydrate: Magnesium is an intracellular positive ion, it reduces the excitability of neurons and neuromuscular transmission. Magnesium participates in yeast reactions. Magnesium lactate dihydrate is used orally in the treatment of magnesium deficiency.

2. Indications and contraindications to the use of Magdivix

2.1.Indications Magdivix is ​​used in the treatment of the following cases:
Severe magnesium deficiency, separately or in combination. In case of concomitant calcium deficiency, in most cases magnesium must be supplemented before calcium supplementation. Functional disorders of anxiety attacks associated with hyperventilation (also called visceral seizures) in the absence of specific treatment. 2.2.Contraindications Severe renal failure, creatinine clearance < 30ml/min. Allergy or hypersensitivity to any ingredient in Magdivix.

3. How to take Magdivix

Magdivix is ​​taken orally, each time the patient should drink it with plenty of water. Divide the dose of Magdivix below into 2-3 times, use in the morning, noon, and afternoon. Do not use Magdivix with the dosage form of film-coated tablets for children.
Average dose in adults:
Patients with severe magnesium deficiency: 6 tablets/24 hours. Seizures: 4 tablets/24 hours. In the case of elderly people, liver failure, mild or moderate kidney failure, there is no need to reduce the dose of Magdivix.
Overdosage of Magdivix and management
Diarrhea may occur with an overdose of Magdivix, due to the effect of soluble magnesium salts on the intestinal tract. Treatment of Magdivix overdose is mainly symptomatic supportive treatment.

4. Notes when using the drug Magdivix

Using high doses of Magdivix for a long time can cause vitamin B6 dependence syndrome.
Pregnant women: Magnesium crosses the placenta. Use magnesium in pregnant women only when clearly needed. Avoid using the drug within two weeks of giving birth. During the use of magnesium in pregnant women, it is necessary to monitor the fetal heart rate. Using vitamin B6 in supplemental doses according to daily needs is not harmful to the fetus. However, long-term use of high doses of Magdivix can cause drug dependence syndrome in infants. Lactation: Magnesium is excreted in breast milk, therefore Magdivix should not be administered to a nursing woman.

5. Undesirable effects when using the drug Magdivix

Possible side effects when using Magdivix: diarrhea, abdominal pain. Less common: nausea, vomiting.
High doses of vitamin B6 >200mg/day for longer than 2 months can cause severe peripheral neuropathy. Manifestations range from unsteady gait and numbness of the feet to clumsiness and numbness of the hands. These symptoms can be reversed when the drug is stopped, but still leave some sequelae.

6. Drug interactions

Preparations containing phosphate, calcium salts: inhibit the absorption of magnesium in the small intestine. Therefore, the concomitant use of Magdivix with the above drugs should be avoided. Oral Tetracycline: In case of concomitant use with Magdivix, these two drugs should be taken at least 3 hours apart. Levodopa: pyridoxine reduces the effects of drugs used to treat Parkinson's disease. Oral contraceptives: increase the daily requirement of pyridoxine. Phenyltoin, phenobarbital: High doses of 200 mg/day of pyridoxine caused a 40-50% reduction in blood levels of these drugs in some patients. Magdivix has two main active ingredients, magnesium and vitamin B6. Magdivix is ​​used in adults to treat severe magnesium deficiency and visceral convulsions. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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