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Mabthera is a drug used in the treatment of cancer. Before using Mabthera, patients need to consult their doctor and take the medicine as prescribed. To better understand the use of Mabthera, you can refer to the article below.1. What is Mabthera?
Mabthera is on the list of drugs that fight cancer and affect the patient's immune system. Besides, the drug Mabthera contains the main ingredient is Rituximab - this is a monoclonal antibody:
Rituxiamb concentrates mainly on lymphocytes in the thymus and in the white marrow of the spleen, in most B lymphocytes in the body. peripheral blood and in the lymph nodes. Certain factors such as age, weight and gender do not affect the effectiveness of Mabthera treatment.
2.Indications of the drug Mabthera
Mabthera drug is prescribed by a specialist with a number of specific pathologies as follows:
Non-Hodgkin's lymphoma B line, CD20 (+); Chronic lymphocytic leukemia CD20 (+); Rheumatoid arthritis ; Granulomatosis with polyangiitis or polyangiitis. To ensure safety, patients should consult their treating doctor about the indications before using Mabthera.
3. Contraindications Mabthera
Do not use the drug in patients who are allergic to Rituximab. Do not use Rituximab for infants and young children.
4. Dosage of Mabthera
How to use:
Rituximab is put into the patient's body through intravenous infusion. Patients should take acetaminophen (Tylenol) and an antihistamine prior to Rituximab infusion to reduce the severity of infusion reactions. Patients with rheumatoid arthritis may receive Methylprednisolone 100mg or a similar drug 30 minutes before the infusion to reduce the severity of the infusion reaction. Dosage:
For Non-Hodgkin's B-cell Lymphoma: 375mg/m2 weekly for 4 to 8 weeks or longer. For chronic lymphocytic leukemia: 375mg/m2 for the first cycle. Then dosing 500 mg/m2 every 28 days for cycle 2 to 6. For granulomatous disease with polykeratitis or microscopic polykeratitis: 375mg/m2; For rheumatoid arthritis: 2 infusions of 1000mg given 2 weeks apart. Then be repeated every 16 to 24 weeks.
5. Possible side effects when using Mabthera
During the use of Mabthera, patients may experience some unwanted effects such as:
Virus infection, parasitic infection or infection. Decrease in white blood cells and neutrophils. Angioedema. Digestive system disorders with manifestations: Nausea, diarrhea, constipation and abdominal pain. Cough, shortness of breath, fatigue, weakness, rash, itching. Fever, chills, headache. Joint pain, bone pain, and limb headache. Pain and erythema or swelling at the site of subcutaneous injection. If you experience the above symptoms, the patient should stop taking Mabthera and notify the doctor for timely treatment.
6. Some notes when taking Mabthera
People with neutrophils < 1.5 × 109/L, platelets < 75 × 109/L or with recurrent infections need caution when taking Mabthera. People with fast-growing tumors, infiltrating lung cancer or experiencing respiratory failure who are at risk of severe reactions to infusion should be monitored further, if necessary, the infusion rate must be reduced. Patients with hepatitis B relapse when taking Mabthera can lead to fulminant hepatitis, liver failure that can lead to death. Therefore, caution should be exercised when using it. Mabthera must be stopped if you are infected with hepatitis B. It is necessary to prevent bacterial, fungal, and viral infections for patients during treatment with Mabthera. Patients with heart failure, worsening angina or arrhythmia should be cautious during treatment with Mabthera. Pregnant and lactating women should be careful when using Mabthera. Store the Mabthera vial in the refrigerator at 2 to 8 degrees Celsius, do not freeze. Above is the information on the use and uses of Mabthera. To ensure safety for health and to use the drug effectively, patients should take Mabthera exactly as prescribed and guided by the treating doctor.
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