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Lykapanzol is classified as a proton pump inhibitor, used in cases of gastric reflux, gastric ulcer. Lykapanzol dosage and side effects to note when using will be in the article below.
1. What is Lykapanzol drug?
Lykapanzol is a medicine used to treat peptic ulcers and gastroesophageal reflux disease. Lykapanzol is available as a lyophilized powder for injection. With packing specifications including 1 vial of powder and 1 ampoule of solvent 10ml of 0.9% NaCl solution, Lykapanzol is used intravenously or intravenously.2. Effects of drug Lykapanzole
Lykapanzol has the active ingredient Pantoprazole. This active ingredient is a drug with a proton pump inhibitor function. The main effect of pantoprazole after entering the body is to enter the acid-secreting tubules in the parietal cells of the stomach, and then convert it to sulfenamide in the active form. This form will irreversibly bind to the enzyme H+/K+-ATPase (proton pump enzyme) for the purpose of inhibiting this enzyme. When the enzyme H+/K+-ATPase is inhibited, the final link of gastric acid secretion.
Studies show that Lykapanzol has an anti-secretory effect on gastric acid even when the stomach is irritated by any cause. The anti-secretory effect of Lykapanzol has been shown to last for more than 24 hours.
With an intravenous dose, Lykapanzol has an effect starting 15 minutes after injection, the effect of the drug lasts for 24 hours with an injection dose of 20-80mg. Note, 80mg is the maximum dose to prolong the drug effect for 24 hours. Lykapanzol is mainly metabolised in the liver by enzymes. In patients with mild hepatic impairment, this process is slowed and leads to higher plasma concentrations and elimination half-life of Lykapanzol. Also taller than the average person. 80% of the active metabolites are excreted by the kidneys, and 18% are excreted in the bile in the feces.
3. Indications for the use of Lykapanzole
Lykapanzol is indicated in the following cases:
Patients with gastroesophageal reflux disease. Prophylactic treatment of gastric and duodenal ulcers when patients use non-steroidal anti-inflammatory drugs. Treatment of gastric acid secretion in pathologies such as Zollinger-Ellison syndrome.
4. Contraindications to the use of Lykapanzole
Lykapanzol drug is contraindicated in case the patient is sensitive to the components of the drug.
5. Dosage and how to use Lykapanzol
How to use Lykapanzol drug:
Intravenous injection: Mix the drug by dissolving the vial of Lykapanzol powder with 10ml of 0.9% NaCl solution, performing slow intravenous injection for at least 2 minutes Intravenous infusion: Mix the drug by dissolving the vial Lykapanzol powder with 100ml of 0.9% NaCl solution or 5% Dextran solution, Ringer Lactate. For intravenous administration, the solution should be infused over about 15 minutes. Note when using Lykapanzol drug: Solution for drug preparation should only be mixed with Lykapanzol powder, not mixed or mixed with any other drugs. The solution after reconstitution should be used within 12 hours to ensure safety and microbiology. If the dose is 20mg of Lykapanzol, use only half the volume of the solution for the preparation, discarding the rest. Dosage of Lykapanzol:
Gastric ulcer, severe gastroesophageal reflux disease: 40mg/time/day, injection or intravenous infusion. Patients with severe hepatic impairment: Reduce dose to half (20mg/time/day) or 40mg dose taken every other day. Patients with renal impairment: No dose adjustment is required. Should not be used for children because there are no documented side effects as well as safety on this subject. Note: Intravenous treatment should only be for a short time, switch to oral as soon as possible (symptoms are greatly reduced).
6. Lykapanzole side effects
Common side effects reported in patients when using Lykapanzol:
Common: headache, mild diarrhea, nausea, abdominal pain, rash, itching and slight dizziness. Rare: edema, thrombophlebitis, fever.
7. Notes when using Lykapanzole drug
It is necessary to exclude the possibility of stomach cancer before taking Lykapanzol because the drug can mask the symptoms of stomach cancer. When used in people with cirrhosis, liver failure, it is necessary to monitor liver function. Although there is no need to adjust the dose in patients with renal failure, it still needs to be used with caution in this subject. Do not use Lykapanzol in children. The effect of the drug on pregnant and lactating mothers has not been established, so it should not be used in this population. Lykapanzol has side effects that affect the nervous system, so users should not drive or operate machinery. Lykapanzol is a drug that inhibits gastric acid secretion, used in the treatment and prevention of peptic ulcers, reflux syndrome caused by stomach acid. Lykapanzol is an injectable drug, so patients are only allowed to use it when prescribed by a specialist.
