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Lipagim drug is used in the treatment of dyslipoproteinemia, in combination with a reasonable diet. Helps lower bad cholesterol and fats (LDL, triglycerides) and increase good cholesterol (HDL) in the blood.
1. What is Lipagim?
1.1 Uses of Lipagim Lipagim's main ingredient is Fenofibrate, used in the treatment of dyslipoproteinemia types IIa, IIb, III, IV and V. Treatment in combination with diet adjustment.
The drug works to increase the enzyme that breaks down fats in the blood, thereby reducing blood cholesterol and reducing blood triglycerides of the fibrates group. Lipagim has the effect of reducing "bad" cholesterol by 20 to 25% and reducing blood triglycerides by up to 50%.
Reduces blood cholesterol by reducing agents that cause atherosclerosis (LDL - Cholesterol). The drug improves the distribution of cholesterol in the blood by reducing the ratio of total cholesterol to HDL cholesterol.
Lipagim increases apoprotein A1 and decreases apoprotein B, improves apo A1/apo B ratio, which is a factor in atherosclerosis. Lipagim is eliminated mainly in the urine in the form of fenofibric acid and its conjugated glucuronic derivative, which is completely eliminated after 6 days. The drug does not cause accumulation in the body.
1.2 Indications of the drug Lipagim Hypercholesterolemia (type IIa); Hypertriglyceridemia (type IV); Combined hyperlipidaemia (types IIb & III) after a correct and appropriate dietary regimen has been unsuccessful. Secondary, persistent hypercholesterolemia despite treatment of the underlying dyslipidaemic cause (as in diabetes mellitus). Continue to maintain a lipid-restricted diet. 1.3 Dosage and administration How to use
Combine with a lipid-restricted diet when using the drug. Take the medicine with a meal to increase its effect. Dosage
Adults:
Take 1 tablet (300mg)/day; Or 1 tablet (100mg) x 3 times/day. Initial dose: 200mg/day (1 or 2 times). For total cholesterol > 4 g/l, the dose can be increased to 300 mg/day. Administer initial dose until blood lipids return to normal; then reduce the daily dose slightly. Check blood cholesterol level every 3 months. If the blood lipid index is increased, the dose must be increased to 300 mg/day. Children > 10 years old:
The cause of hyperlipidemia must be determined in the child. The maximum recommended dose is 5mg/kg/day. Very high hyperlipidemia accompanied by clinical signs of atherosclerosis, parents with cardiovascular manifestations due to atherosclerosis before the age of 40,...) use higher doses. If lipid levels in the blood do not decrease significantly after 3 to 6 months of treatment with Lipagim, a change in therapy (additional or other therapy). Take the drug at the main meal; in combination with a lipid-lowering diet.
2. Note when using Lipagim
Contraindications:
Allergy to Fenofibrate or to other components of the drug. Severe kidney failure. Liver function disorders, biliary tract diseases. Children under 10 years old. Patients who have had an allergic reaction to light when using fibrates or ketoprofen. Pregnant and lactating women should not use Lipagim. Note:
Check the patient's liver and kidney function before taking Lipagim. After 3 to 6 months of taking the drug, blood cholesterol levels do not decrease, requiring additional or alternative treatment. Elevated liver enzymes are usually temporary. Discontinue treatment if liver enzymes (SGOT, SGPT) rise above 3 times the normal limit. If Lipagim is combined with oral anticoagulants, blood clotting time (prothrombin) should be monitored. Diseases of the biliary tract can occur in patients with cholestatic cirrhosis or gallstones. Patients with hypothyroidism can cause muscle side effects.
3. Side effects of Lipagim
Common:
On the digestive system: digestive disorders, feeling of indigestion, epigastric pain, nausea, diarrhea. On the skin: allergy, erythema, urticaria. In the liver: increased transaminases. In muscle: muscle pain, possibly muscle wasting. Rare:
Increased risk of gallstones. On the genitourinary system: decreased libido, impotence, decreased sperm count. Hematology: leukopenia.
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